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Plicatamide: A lead to the biosynthetic origins of the tunichromes?

Abstract：

:Plicatamide is a modified octapeptide from the ascidian Styela plicata having the structure Phe-Phe-His-Leu-His-Phe-His-decarboxyDeltaDOPA (where decarboxyDeltaDOPA = decarboxy-(E)-alpha,beta-dehydro-3, 4-dihydroxyphenylalanine). Edman sequencing, tandem mass spectrometry, and proton NMR have been used to characterize 100 microg of the compound. Plicatamide represents an important link between two classes of biomolecules: the tunichromes which share an oxidatively decarboxylated C-terminus and higher molecular weight DOPA-polypeptides. The 8-residue sequence provides the first opportunity to investigate the biosynthetic origins of the tunichrome family by molecular biological techniques.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tincu JA,Craig AG,Taylor SW

doi

10.1006/bbrc.2000.2449

subject

Has Abstract

pub_date

2000-04-13 00:00:00

pages

421-4

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)92449-5

journal_volume

270

pub_type

杂志文章

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