Adipocytes recognize and degrade oxidized low density lipoprotein through CD36.

abstract：:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It wa...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

更新日期：2009-07-31 00:00:00

abstract：:We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta s...

journal_title：Biochemical and biophysical research communications

authors： DeCherney GS,Gesundheit N,Gyves PW,Showalter CR,Weintraub BD

更新日期：1989-03-15 00:00:00

abstract：:We showed previously [K. Moissoglu, I.H. Gelman, J. Biol. Chem. 278 (2003) 47946-47959] that oncogenic v-Src could induce 7- to 10-fold greater anchorage-independent growth (AIG) in FAK-null mouse embryo fibroblasts (MEF) compared to those expressing FAK. Here, we demonstrate that the enhanced AIG (eAIG) correlates wi...

journal_title：Biochemical and biophysical research communications

authors： Moissoglu K,Sachdev S,Gelman IH

更新日期：2005-05-13 00:00:00

abstract：:17α-estradiol is a hormonally inactive isomer of 17β-estradiol, but with similar potency as neuroprotector. However, we have previously reported that pretreatment with high concentration (10 μM) of both estrogens abolishes their neuroprotection in rat cerebellar granule neurons. Here, we have examined neuroprotective ...

journal_title：Biochemical and biophysical research communications

authors： Sørvik IB,Paulsen RE

更新日期：2017-08-26 00:00:00

abstract：:Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. In this study, we examined the e...

journal_title：Biochemical and biophysical research communications

authors： Yoshimura T,Saitoh K,Sun L,Wang Y,Taniyama S,Yamaguchi K,Uchida T,Ohkubo T,Higashitani A,Nikawa T,Tachibana K,Hirasaka K

更新日期：2018-12-02 00:00:00

abstract：:The complete covalent structure of the gamma 2 subunit of bovine brain G proteins was determined by peptide mapping using matrix-assisted laser desorption ionization and electrospray ionization mass spectrometry and by partial sequencing using tandem mass spectrometry. Fragments were identified in proteolytic digests ...

journal_title：Biochemical and biophysical research communications

authors： Wilcox MD,Schey KL,Busman M,Hildebrandt JD

更新日期：1995-07-17 00:00:00

abstract：:The characterization of the genomic organization of the B2 bradykinin receptor gene enabled us to systematically search for polymorphic markers in this gene in a South German cohort (N = 179). We identified at least three polymorphic sites in each of the three exons existing: (i) in exon 1 next to the promoter region,...

journal_title：Biochemical and biophysical research communications

authors： Braun A,Kammerer S,Böhme E,Müller B,Roscher AA

更新日期：1995-06-06 00:00:00

abstract：:In continuation of our recent observations indicating the presence of a lone calcineurin-dependent response element (CDRE) in the -3730bp upstream region of copper-induced metallothionein (CuMT) gene of Neurospora [K.S. Kumar, S. Dayananda, C. Subramanyam, Copper alone, but not oxidative stress, induces copper-metallo...

journal_title：Biochemical and biophysical research communications

authors： Kumar KS,Ravi Kumar B,Siddavattam D,Subramanyam C

更新日期：2006-07-07 00:00:00

abstract：:Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the f...

journal_title：Biochemical and biophysical research communications

authors： Luo J,Zhang L,Stenn K,Prouty S,Parimoo S

更新日期：2005-02-04 00:00:00

abstract：:X-linked Emery-Dreifuss muscular dystrophy is usually caused by absence of the nuclear membrane protein, emerin, due to nonsense mutations or deletions, but a few missense mutations also exist. A pathogenic g993t mutation causes a Q133H change in the nuclear targeting region of emerin, but it may also reduce emerin le...

journal_title：Biochemical and biophysical research communications

authors： Holt I,Clements L,Manilal S,Morris GE

更新日期：2001-10-12 00:00:00

abstract：:1,25(OH)2D3 receptors were studied in whole testes, Sertoli cells, seminiferous tubules, Leydig cells and spermatogonia of adult NMRI mice and SD rats. Specific reversible high affinity binding (KD 1.4 x 10(-10)M; Nmax 72 fmol/mg protein) by a 3.5 S macromolecule was demonstrated in whole testes, Sertoli cells and sem...

journal_title：Biochemical and biophysical research communications

authors： Merke J,Hügel U,Ritz E

更新日期：1985-02-28 00:00:00

abstract：:Sirt1 appear to be NAD(+)-dependent deacetylase that deacetylates histones and several non-histone proteins. In this study, we identified Sirt1 as a physical interaction partner of Tip60, which is a mammalian MYST-type histone acetyl-transferase that specifically acetylates histones H2A and H4. Although Tip60 also ace...

journal_title：Biochemical and biophysical research communications

authors： Yamagata K,Kitabayashi I

更新日期：2009-12-25 00:00:00

abstract：:The AML1 gene encodes DNA-binding proteins that contain the Runt domain and is found at the breakpoints of some translocations associated with leukemias. It has been reported that AML1 plays pivotal roles in myeloid differentiation, probably through the transcriptional regulation of various hematopoietic genes. Here w...

journal_title：Biochemical and biophysical research communications

authors： Imai Y,Kurokawa M,Tanaka K,Friedman AD,Ogawa S,Mitani K,Yazaki Y,Hirai H

更新日期：1998-11-27 00:00:00

abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

journal_title：Biochemical and biophysical research communications

authors： Omkumar RV,Gaikwad AS,Ramasarma T

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:Resistin is associated with insulin resistance, and determining its developmental and molecular mechanisms may help the development of novel treatments. MicroRNAs (miRNAs) are involved in many physiological and pathological processes as negative regulators. However, it remains unclear whether miRNAs play a r...

journal_title：Biochemical and biophysical research communications

authors： Wen F,Yang Y,Jin D,Sun J,Yu X,Yang Z

更新日期：2014-03-07 00:00:00

abstract：:DENN domains are found in a variety of signaling proteins but their exact function remains undefined. Some of the DENN-containing proteins, such as rat Rab3GEP (Rab3 GDP/GTP exchange protein) or mouse Rab6IP1 (Rab6 interacting protein 1) interact with GTPases of the Rab family. Others, such as human MADD (MAP (Mitogen...

journal_title：Biochemical and biophysical research communications

authors： Levivier E,Goud B,Souchet M,Calmels TP,Mornon JP,Callebaut I

更新日期：2001-09-28 00:00:00

abstract：:L-arginine may aid in the liver detoxification and may benefit in the treatment of liver disorders such as liver injury. The present study was to investigate the possible protective and curative effects of L-arginine on carbon tetrachloride (CCl(4)) induced hepatotoxicity. Mice received a single dose of CCl(4). L-argi...

journal_title：Biochemical and biophysical research communications

authors： Saad EA

更新日期：2012-06-22 00:00:00

abstract：:One of the monocytic cell colony stimulating factors produced by thymic myoid cells, a 100 kDa factor, was purified by reversed phase HPLC and found to be homologous to the secreted form of proteoglycan 1 (biglycan) core protein. This biglycan associated colony stimulating factor did not carry an immunological motif o...

journal_title：Biochemical and biophysical research communications

authors： Kamo I,Kikuchi A,Nonaka I,Yamada E,Kondo J

更新日期：1993-09-15 00:00:00

abstract：:Analysis of endothelial cell (EC) chemokine receptor expression by RT-PCR revealed that EC essentially do not express CC-chemokine receptors whereas they express all known CXC-chemokine receptors. Endotheliotropic functions of ligands for CXCR-1, CXCR-2, and CXCR-3 have previously been described. We have consequently ...

journal_title：Biochemical and biophysical research communications

authors： Feil C,Augustin HG

更新日期：1998-06-09 00:00:00

abstract：:The peroxidase and FAD-containing monooxygenase activities of porcine thyroid subcellular preparations were measured and it was observed that FAD-containing monooxygenase activity was considerably lower than that of peroxidase. The end product of 1-methyl-2[14C]thioimidazole oxidation catalysed by thyroid peroxidase w...

journal_title：Biochemical and biophysical research communications

authors： Paterson JR,Hood HT,Skellern GG

更新日期：1983-10-31 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is involved in DNA repair and activated by DNA damage. When activated, PARP-1 consumes NAD(+) to form ADP-ribose polymers on acceptor proteins. Extensive activation of PARP-1 leads to glycolytic blockade, energy failure, and cell death. These events have ...

journal_title：Biochemical and biophysical research communications

authors： Ying W,Garnier P,Swanson RA

更新日期：2003-09-05 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex. Increased expression of T...

journal_title：Biochemical and biophysical research communications

authors： Buyandelger U,Walker DG,Taguchi H,Yanagisawa D,Tooyama I

更新日期：2020-11-19 00:00:00

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:The Forkhead/Fox transcription factor Foxc2 is a critical regulator of vascular development. However, the role of Foxc2 in pathological angiogenesis in cancer remains unknown. Here we show that FoxC2 is highly expressed in human breast and colonic tumors and in the tumor endothelium in human and mouse melanomas. Using...

journal_title：Biochemical and biophysical research communications

authors： Sano H,Leboeuf JP,Novitskiy SV,Seo S,Zaja-Milatovic S,Dikov MM,Kume T

更新日期：2010-02-05 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

journal_title：Biochemical and biophysical research communications

authors： Ladoux A,Frelin C

更新日期：1993-09-15 00:00:00

abstract：:A high-pressure stopped-flow apparatus developed in our laboratories provides the capability to use dissolved gaseous reactants at elevated concentrations in solution (in equilibrium with gas pressures up to ca. 30 atm) for measurement of reaction kinetics. We have used this apparatus to follow the reaction of dioxyge...

journal_title：Biochemical and biophysical research communications

authors： Bailey JA,James CA,Woodruff WH

更新日期：1996-03-27 00:00:00

abstract：:TGF beta is a multifunctional cytokine that regulates alveolar epithelial cells as well as immune cells and fibroblasts. TGF beta inhibits surfactant protein A, B and C expression in fetal human lung and can inhibit type II cell proliferation induced by FGF7 (KGF). However, little is known about direct effects of TGF ...

journal_title：Biochemical and biophysical research communications

authors： Correll KA,Edeen KE,Zemans RL,Redente EF,Mikels-Vigdal A,Mason RJ

更新日期：2018-05-23 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-herpesvirus that is frequently associated with the formation of tumors like Kaposi's sarcoma and primary effusion lymphomas. KSHV RTA is required for lytic replication/reactivation in KSHV-infected cells. We developed an inducible RTA expression cell line to se...

journal_title：Biochemical and biophysical research communications

authors： Yada K,Do E,Sakakibara S,Ohsaki E,Ito E,Watanabe S,Ueda K

更新日期：2006-06-23 00:00:00

abstract：:The membrane electroporation-induced inward current (IMEP) in pituitary tumor (GH3) cells was characterized. This current emerges irregularly when membrane hyperpolarizations to -200 mV with a holding potential of -80 mV were elicited. Neither E-4031 (10 μM), glibenclamide (30 μM), nor ZD7288 (30 μM) caused any effect...

journal_title：Biochemical and biophysical research communications

authors： Wu SN,Huang HC,Yeh CC,Yang WH,Lo YC

更新日期：2011-02-18 00:00:00

abstract：:A heparin-binding Mr 25,000 immunoreactive bFGF-like protein (ir-bFGF) is recognized in adult rat liver extract by affinity-purified polyclonal anti-human placental bFGF antibodies. Hepatic levels of this protein increase 4-fold in regenerating rat liver during the first 48 h after partial hepatectomy. Also, they appe...

journal_title：Biochemical and biophysical research communications

authors： Presta M,Statuto M,Rusnati M,Dell'Era P,Ragnotti G

更新日期：1989-11-15 00:00:00