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Characterization of a Mr 25,000 basic fibroblast growth factor form in adult, regenerating, and fetal rat liver.

Abstract：

:A heparin-binding Mr 25,000 immunoreactive bFGF-like protein (ir-bFGF) is recognized in adult rat liver extract by affinity-purified polyclonal anti-human placental bFGF antibodies. Hepatic levels of this protein increase 4-fold in regenerating rat liver during the first 48 h after partial hepatectomy. Also, they appear to be higher in embryonic than in newborn or in adult rat liver. Mr 25,000 ir-bFGF from regenerating rat liver, partially purified by heparin-affinity chromatography, induces plasminogen activator activity and cell proliferation in transformed fetal bovine aortic endothelial GM 7373 cells and competes with Mr 18,000 [125I]bFGF for the binding to high affinity bFGF receptors. The data indicate the presence in rat liver of a high molecular weight form of bFGF whose expression is modulated during embryonic development and liver regeneration.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Presta M,Statuto M,Rusnati M,Dell'Era P,Ragnotti G

doi

10.1016/0006-291x(89)91794-4

subject

Has Abstract

pub_date

1989-11-15 00:00:00

pages

1182-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91794-4

journal_volume

164

pub_type

杂志文章

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