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Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes.

Abstract：

:We report a 39 kDa substrate for cholera and pertussis toxins is present in D. discoideum membranes. This protein did not co-migrate with alpha subunits of either Gs (45 kDa and 52 kDa) or Gi (41 kDa) from control mammalian cells. The presence of GTP or its non-hydrolyzable analogs enhanced the ADP-ribosylation in response to cholera toxin, but did not significantly alter ADP-ribosylation by pertussis toxin. Divalent cations inhibited the ADP-ribosylation by both toxins. The possible association of this novel G-protein with D. discoideum adenylate cyclase may underlie some of the unique regulatory features of this enzyme. Alternatively, this G-protein may regulate one of several other cellular responses mediated by the cAMP receptor.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Khachatrian L,Klein C,Howlett A

doi

10.1016/0006-291x(87)90504-3

subject

Has Abstract

pub_date

1987-12-31 00:00:00

pages

975-81

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90504-3

journal_volume

149

pub_type

杂志文章

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