当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Antibody to human lymphocyte actin regulates immunoglobulin secretion by an EBV-transformed human B-cell line.

Antibody to human lymphocyte actin regulates immunoglobulin secretion by an EBV-transformed human B-cell line.

Abstract：

:Antibody against actin isolated from a human EBV-transformed lymphoblastoid B-cell line exerted an inhibitory effect on in vitro IgM secretion by a different lymphoblastoid B-cell line, LA350. This effect was dose dependent showing from 24-40% inhibition at a dilution of 1:100 and 68-80% inhibition at a dilution of 1:50. This effect was noted in the absence of changes in either total cell count or [3H]-thymidine incorporation and was reversed by co-incubation with purified rabbit thymus actin (100 micrograms/ml) but not bovine serum albumin at the same concentration. These data demonstrate regulation of immunoglobulin synthesis by antibodies against human lymphocyte derived actin in a lymphoblastoid B-cell line.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rosenblatt HM,Green CG,McClure JE,Shearer WT

doi

10.1016/0006-291x(86)91104-6

subject

Has Abstract

pub_date

1986-10-15 00:00:00

pages

399-405

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)91104-6

journal_volume

140

pub_type

杂志文章

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