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Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type.

Abstract：

:CD44 is a major cell-surface receptor for hyaluronate (HA). By alternative RNA-splicing a large number of CD44 variants are generated. To explore the role of CD44 splicing in the regulation of cell binding to HA, three different isoforms of CD44 were transfected in the CD44 negative B-cell lymphoma line Namalwa and in the fibroblastoid cell line COS7. We observed that whereas the standard form of CD44 (CD44s) mediated adhesion of Namalwa to HA, Namalwa transfected with CD44v3-10 or CD44v8-10 was unable to bind to either immobilized or soluble HA. After stimulation of CD44 with an activating anti-CD44 mAb or with phorbol ester, the binding of CD44s to HA was 5- to 10-fold higher than that of the other two isoforms. By contrast, COS7 cells transfected with CD44s, CD44v8-v10, or CD44v3-v10 bound equally effectively to HA. Hence, in addition to alternative splicing, cell type determines CD44 binding to HA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

van der Voort R,Manten-Horst E,Smit L,Ostermann E,van den Berg F,Pals ST

doi

10.1006/bbrc.1995.2267

subject

Has Abstract

pub_date

1995-09-05 00:00:00

pages

137-44

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X8572267X

journal_volume

214

pub_type

杂志文章

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