Expression of a functional IL-13Ralpha1 by rat B cells.

abstract：:A fusion protein comprising the DNA-binding region of the glucocorticoid receptor and the catalytic domain of poly(ADP-ribose) polymerase was constructed. This chimeric protein was expressed both in E. coli and in eukaryotic cells and was recognized by antibodies to both polymerase and the glucocorticoid receptor. Sim...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal D,Hong T,Cherney B,Zhang S,Shima T,Danielsen M,Smulson M

更新日期：1994-07-29 00:00:00

abstract：:Previously it was known that cytosolic Ca(2+) elevation was involved in regulating UV- or TNFalpha-induced apoptosis. Here, we reported new evidence that mitochondrial Ca(2+) signal is also involved in the apoptotic process. First, using living cell imaging techniques, we observed multiple mitochondrial Ca(2+) spikes ...

journal_title：Biochemical and biophysical research communications

authors： Lao Y,Chang DC

更新日期：2008-08-15 00:00:00

abstract：:The molecular mechanisms underlying ultrasound-induced apoptosis remain poorly understood. We have demonstrated that in Jurkat cells, the over-expression of the anti-apoptotic protein Bcl-2 inhibited ultrasound-induced apoptosis, but not necrosis. Inhibition of caspase activity also protected the cells from apoptosis,...

journal_title：Biochemical and biophysical research communications

authors： Kinoshita M,Eguchi Y,Hynynen K

更新日期：2007-02-09 00:00:00

abstract：:Anders et al. (2011) [11] reported that cyclinD1/Cdk4 and cyclinD3/Cdk6 enhance the transcriptional activity of FOXM1c by phosphorylating its TAD. They defined 12 Cdk consensus sites as essential for the activation of FOXM1c by cyclinD1/Cdk4 and cyclinD3/Cdk6 and stated that the 12 Cdk-sites are positioned within the ...

journal_title：Biochemical and biophysical research communications

authors： Wierstra I

更新日期：2013-02-22 00:00:00

abstract：:Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CC...

journal_title：Biochemical and biophysical research communications

authors： Hou S,Fang M,Zhu Q,Liu Y,Liu L,Li X

更新日期：2017-02-26 00:00:00

abstract：:Two-pore channel proteins, TPC1 and TPC2, are calcium permeable ion channels found localized to the membranes of endolysosomal calcium stores. There is increasing interest in the role of TPC-mediated intracellular signaling in various pathologies; however their role in breast cancer has not been extensively evaluated....

journal_title：Biochemical and biophysical research communications

authors： Jahidin AH,Stewart TA,Thompson EW,Roberts-Thomson SJ,Monteith GR

更新日期：2016-09-02 00:00:00

abstract：:Osteoclasts are hematopoietic cells essential for bone resorption. To understand the process of osteoclastogenesis, we have developed a culture system that employs a stromal cell line, in which differentiation of osteoclasts from single embryonic stem (ES) cells occurs. This culture, which did not require any cell pas...

journal_title：Biochemical and biophysical research communications

authors： Hemmi H,Okuyama H,Yamane T,Nishikawa S,Nakano T,Yamazaki H,Kunisada T,Hayashi S

更新日期：2001-01-19 00:00:00

abstract：:During IFN alpha stimulation, p59(fyn) associates with the Type I IFNR-associated Tyk-2 kinase in several human hematopoietic cell lines in vivo. This interaction is direct, and is mediated by the SH2 domain in p59(fyn), as shown by binding studies using glutathione-S-transferase fusion proteins and far western blots....

journal_title：Biochemical and biophysical research communications

authors： Uddin S,Sher DA,Alsayed Y,Pons S,Colamonici OR,Fish EN,White MF,Platanias LC

更新日期：1997-06-09 00:00:00

abstract：:We have selected calcium ionophore (A23187)-resistant cells (AR-7) in a human promyelocytic leukemia cell line, HL-60. AR-7 showed approximately 8.5-fold resistance to A23187 compared with the wild type cells after continuous exposure for 3 days. AR-7 had cross resistance to ionomycin (4.6-fold) and thapsigargin (340-...

journal_title：Biochemical and biophysical research communications

authors： Kubota M,Kataoka A,Okuda A,Bessho R,Lin YW,Wakazono Y,Usami I,Akiyama Y,Furusho K

更新日期：1995-08-15 00:00:00

abstract：:The atrial natriuretic factor (ANF) secreted from rat cardiocytes in culture was purified and characterized. The purification procedure involves extraction of ANF by activated Vycor glass, followed by HPLC on C18 mu Bondapak and Vydac columns. The detection of ANF in column eluates was performed by a simple and sensit...

journal_title：Biochemical and biophysical research communications

authors： Gutkowska J,Lazure C,Racz K,Thibault G,Garcia R,Seidah NG,Chrétien M,Genest J,Cantin M

更新日期：1985-08-15 00:00:00

abstract：:Stress associated proteins (SAPs) in plants contain A20-type zinc finger (A20_ZF) domains and are involved with abiotic stress response. A20-type zinc finger domains in animals reportedly recognize ubiquitin as a regulatory signal in cell. However, it remains unclear whether A20_ZF domains in plants perform similar ro...

journal_title：Biochemical and biophysical research communications

authors： Choi H,Han S,Shin D,Lee S

更新日期：2012-03-09 00:00:00

abstract：:Genetic predisposition is necessary for polycystic kidney disease (PKD) initiation, although there are other, incompletely identified downstream processes that are required for cyst growth. Their characterization may provide a unique opportunity for clinical interventions. One of the poorly studied phenomena in PKD is...

journal_title：Biochemical and biophysical research communications

authors： Arkhipov SN,Pavlov TS

更新日期：2019-05-21 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Liver X receptor (LXR) alpha is known to be involved in the control of cholesterol homeostasis. Thus, the purpose of this study was to investigate the effects of 3-methlycholanthrene (MC), one of the PAHs, on LXRalp...

journal_title：Biochemical and biophysical research communications

authors： Iwano S,Nukaya M,Saito T,Asanuma F,Kamataki T

更新日期：2005-09-16 00:00:00

abstract：:Peptides simultaneously produced during maturation and degradation of peptidergic hormones and functional proteins have recently become a great interest because they display unpredictably different biological roles than the parent proteins. Namely, we discovered two novel functional cryptic peptides, mitocryptide-1 (M...

journal_title：Biochemical and biophysical research communications

authors： Seki T,Fukamizu A,Kiso Y,Mukai H

更新日期：2011-01-07 00:00:00

abstract：:Peripheral blood monocytes (PBMC) promote vascular inflammation and atherosclerosis. Chlamydia pneumoniae (Cp) infection of PBMC is found in atherosclerotic patients, appears refractory to antibiotics, and may predispose to vascular damage. In Cp-infected human PBMC we analyzed the role of cyclooxygenase-2 (Cox-2) for...

journal_title：Biochemical and biophysical research communications

authors： Rupp J,Berger M,Reiling N,Gieffers J,Lindschau C,Haller H,Dalhoff K,Maass M

更新日期：2004-07-30 00:00:00

abstract：:Induction of glycogenolysis in the perfused liver by platelet activating factor (PAF) was blocked by the cyclooxygenase inhibitor indomethacin. 3H-labeled PAF was shown to interact in the perfused liver primarily with Kupffer cells. The addition of PAF to Kupffer cells resulted in a dose-dependent stimulation of prost...

journal_title：Biochemical and biophysical research communications

authors： Kuiper J,De Rijke YB,Zijlstra FJ,Van Waas MP,Van Berkel TJ

更新日期：1988-12-30 00:00:00

abstract：:PQBP-1 was identified as a binding protein to the polyglutamine tract present in various transcription-related factors and causative genes for neurodegenerative disorders. This novel gene contains at least two functional domains, WW domain and carboxyl-terminal domain (CTD), strictly conserved beyond species. Although...

journal_title：Biochemical and biophysical research communications

authors： Waragai M,Junn E,Kajikawa M,Takeuchi S,Kanazawa I,Shibata M,Mouradian MM,Okazawa H

更新日期：2000-07-05 00:00:00

abstract：:Endostatin, a natural angiogenesis inhibitor, had been identified for years. It opened a new approach for cancer therapy. Sequence analysis revealed that endostatin is the NC1 domain (non-triple-helical domain) of collagen XVIII. In this report, the cDNA of NC1 domain of type VIII collagen (alpha 1) was cloned and exp...

journal_title：Biochemical and biophysical research communications

authors： Xu R,Yao ZY,Xin L,Zhang Q,Li TP,Gan RB

更新日期：2001-11-23 00:00:00

abstract：:The baculovirus expression system has been used to express large quantities of various proteins, including membrane receptors. Here, we reveal a novel property of this expression system to be that certain membrane proteins can be displayed on the budded virus itself. We introduced the genes encoding sterol regulatory ...

journal_title：Biochemical and biophysical research communications

authors： Urano Y,Yamaguchi M,Fukuda R,Masuda K,Takahashi K,Uchiyama Y,Iwanari H,Jiang SY,Naito M,Kodama T,Hamakubo T

更新日期：2003-08-15 00:00:00

abstract：:We questioned whether glucocorticoids alter the known potent effect of serum to increase glucose transport and GLUT-1 expression in cultured L6 myotubes. Myotubes were exposed to serum-free medium for 24h in the presence or absence of 300 nM dexamethasone and subsequently treated for 8h with 10% serum or serum free me...

journal_title：Biochemical and biophysical research communications

authors： Sivitz WI,Pasley AM

更新日期：1995-01-05 00:00:00

abstract：:BHLHB2/DEC1 is a transcription factor implicated in cell proliferation, apoptosis, and metabolism, and is also known to play an important role in the regulation of the mammalian circadian rhythm. However, its precise role in metabolism remains unclear. We investigated the link between BHLHB2 and ChREBP, a glucose-acti...

journal_title：Biochemical and biophysical research communications

authors： Iizuka K,Horikawa Y

更新日期：2008-09-12 00:00:00

abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

journal_title：Biochemical and biophysical research communications

authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

更新日期：2012-09-07 00:00:00

abstract：:We have previously shown that DNA elements controlling tissue specific expression of the rat thyroglobulin gene extend 170 bp upstream of the cap site and have identified a thyroid specific nuclear factor which binds the promoter in the -60 region (site C). Here we report that the distal portion of the promoter, exten...

journal_title：Biochemical and biophysical research communications

authors： Ursini MV,Gallo A,Olivetta E,Musti AM

更新日期：1989-08-30 00:00:00

abstract：:Multidrug resistance protein 1 (MRP1/ABCC1) is a 190kDa member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters that is clinically relevant for its ability to confer multidrug resistance by actively effluxing anticancer drugs. Knowledge of the atomic structure of MRP1 is needed to elucidate ...

journal_title：Biochemical and biophysical research communications

authors： DeGorter MK,Conseil G,Deeley RG,Campbell RL,Cole SP

更新日期：2008-01-04 00:00:00

abstract：:The acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) is a member of a conserved superfamily of nuclear proteins whose functions are largely unknown. In our previous work, ANP32B was identified as a novel direct substrate for caspase-3 and acted as a negative regulator for leukemic cell apoptosis. In this work, ...

journal_title：Biochemical and biophysical research communications

authors： Yu Y,Shen SM,Zhang FF,Wu ZX,Han B,Wang LS

更新日期：2012-07-13 00:00:00

abstract：:Lysosomal integral membrane protein-2 (LIMP-2) is a type III transmembrane protein that is highly glycosylated and mainly localized to the lysosomal membrane. The diverse functions of LIMP-2 are currently being uncovered; however, its participation in macroautophagy, usually described as autophagy, has not yet been we...

journal_title：Biochemical and biophysical research communications

authors： Sakane H,Urabe J,Nakahira S,Hino K,Miyata N,Akasaki K

更新日期：2020-12-17 00:00:00

abstract：:The post-translational modification of histones has been implicated in the regulation of cellular lifespan. Previously, we reported that cellular aging is associated with increased ubiquitylation of histone H2B and methylation of histone H3 at lysines 4 and 79 in yeast telomeric heterochromatin. Here, we show the anta...

journal_title：Biochemical and biophysical research communications

authors： Ryu HY,Rhie BH,Ahn SH

更新日期：2014-03-28 00:00:00

abstract：:In higher plants, a cis-acting element, DRE/CRT, is involved in gene expression responsive to drought and low-temperature stress. To understand signal transduction pathways from the cold stress signal to gene expression, we characterized a gene family for DRE/CRT-binding proteins DREB1A and CBF1 in Arabidopsis thalian...

journal_title：Biochemical and biophysical research communications

authors： Shinwari ZK,Nakashima K,Miura S,Kasuga M,Seki M,Yamaguchi-Shinozaki K,Shinozaki K

更新日期：1998-09-08 00:00:00

abstract：:The intracellular parasitic protist Trypanosoma cruzi is the causative agent of Chagas disease in Latin America. In general, pyrimidine nucleotides are supplied by both de novo biosynthesis and salvage pathways. While epimastigotes-an insect form-possess both activities, amastigotes-an intracellular replicating form o...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Morales J,Fukai Y,Suzuki S,Takamiya S,Tsubouchi A,Inoue S,Inoue M,Kita K,Harada S,Tanaka A,Aoki T,Nara T

更新日期：2012-01-20 00:00:00

abstract：:Glucocorticoids inhibit rodent alpha-fetoprotein (AFP) gene activity but stimulate expression of the human homologue. Like human, activity of the AFP promoter from other primates was stimulated by the synthetic glucocorticoid dexamethasone (Dex) in various cell lines. A glucocorticoid responsive element (GRE) is locat...

journal_title：Biochemical and biophysical research communications

authors： Nakabayashi H,Koyama Y,Sakai M,Li HM,Wong NC,Nishi S

更新日期：2001-09-14 00:00:00