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Insulin-like growth factor 1 binding protein 3 synthesis by aortic endothelial cells is a function of cell density.

Abstract：

:Proliferating bovine aortic endothelial cells in culture do not express the insulin-like growth factor 1 binding protein 3 gene, in contrast to the genes encoding binding proteins 2, 4, 5, and 6. The binding protein 3 gene is activated only at cell confluency with continual transcription thereafter, for at least an eight-day post-confluent period, both in the presence or absence of serum. Secretion of protein product into the medium parallels transcription. DNA synthesis is inversely related to the amount of total insulin-like growth factor 1 binding protein 3 in the culture medium. The addition of anti-binding protein 3 antibody to media significantly increases the rate of DNA synthesis by extensively post-confluent cells. These data suggest (1) aortic endothelial cells are an important source of circulating binding protein 3, (2) binding protein 3 has an inhibitory effect upon the growth of endothelial cells, (3) the triggering of binding protein 3 synthesis after confluency suggests a role in maintaining the growth-arrested monolayer state of the cells in vivo.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Delafontaine P,Ku L,Anwar A,Hayzer DJ

doi

10.1006/bbrc.1996.0769

subject

Has Abstract

pub_date

1996-05-15 00:00:00

pages

478-82

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90769-X

journal_volume

222

pub_type

杂志文章

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