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The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin.

Abstract：

:Glycosyl-phosphatidylinositol (GPI) anchored proteins are surveyed in two insulin sensitive cell types by surface labeling and phospholipase C-induced release into the medium. Serum starvation selectively increases both the number and intensity of a subset of GPI-anchored proteins. After serum starvation, loss of cell-surface GPI-anchored proteins is induced acutely by either serum re-exposure or insulin, suggesting that hormonal treatment may promote the release of these proteins from the cell surface.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lisanti MP,Darnell JC,Chan BL,Rodriguez-Boulan E,Saltiel AR

doi

10.1016/0006-291x(89)91533-7

subject

Has Abstract

pub_date

1989-10-31 00:00:00

pages

824-32

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91533-7

journal_volume

164

pub_type

杂志文章

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