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The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate.

Abstract：

:Bile acids have emerged as a new class of signaling molecules that play a role in metabolism. Studies in mice have shown that the bile acid receptor TGR5 mediates several of these effects but the metabolic function of TGR5 in humans is less well established. Here we show that human adipose tissue TGR5 expression is positively correlated to obesity and reduced during diet-induced weight loss. Adipose tissue TGR5 expression was also positively correlated to resting metabolic rate. Our study indicates that human adipose tissue contributes to the TGR5 mediated metabolic effects of bile acids and plays a role in energy expenditure.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Svensson PA,Olsson M,Andersson-Assarsson JC,Taube M,Pereira MJ,Froguel P,Jacobson P

doi

10.1016/j.bbrc.2013.03.031

subject

Has Abstract

pub_date

2013-04-19 00:00:00

pages

563-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00446-4

journal_volume

433

pub_type

杂志文章

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