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Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.

Abstract：

:Jmjd2c is a candidate oncogene that encodes histone lysine demethylase. In this study, we discovered that over-expression of Jmjd2c increased the expression of Mdm2 oncogene dependent on its demethylase activity, which led to the reduction of p53 tumor suppressor gene product in the cells. A chromatin immunoprecipitation assay showed that Jmjd2c was recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes. Furthermore, siRNA-mediated knockdown of Jmjd2c caused the reduction of Mdm2 expression in the cells. These results indicate that Mdm2 oncogene is a downstream target of Jmjd2c and may play an important role in Jmjd2c-mediated oncogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishimura A,Terashima M,Kimura H,Akagi K,Suzuki Y,Sugano S,Suzuki T

doi

10.1016/j.bbrc.2009.08.155

subject

Has Abstract

pub_date

2009-11-13 00:00:00

pages

366-71

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01762-8

journal_volume

389

pub_type

杂志文章

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