当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1.

Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1.

Abstract：

:The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a member of the WD-repeat protein family and a component of the histone modifying and remodeling complexes. Previously, we demonstrated that RbAp46 is a potent growth inhibitor that can suppress the transformed phenotype of tumor cells. To explore the molecular mechanisms of RbAp46 function, we used RbAp46 as a bait in a yeast two-hybrid screening and found that RbAp46 interacts specifically with the C-terminal region of BRCA1 (the BRCT domain), a domain involved in the t transactivation activity of BRCA1. Coimmunoprecipitation assays demonstrated that the interaction of RbAp46 with BRCA1 requires the first two of the four Trp-Asp (WD)-repeats of RbAp46. We also showed that expression of RbAp46 represses the transactivation activity mediated by the BRCT/Gal4 fusion protein and inhibits the transactivation of the p21 promoter mediated by the full-length BRCA1. Interestingly, the association of BRCA1 and RbAp46 is disrupted in cells treated with DNA-damaging agents. These results suggest that RbAp46 may specifically interact with BRCA1 and modulate its transactivation activity in response to DNA damage.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen GC,Guan LS,Yu JH,Li GC,Choi Kim HR,Wang ZY

doi

10.1006/bbrc.2001.5003

subject

Has Abstract

pub_date

2001-06-08 00:00:00

pages

507-14

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)95003-X

journal_volume

284

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Different roles of β-arrestin and the PKA pathway in mitochondrial ROS production induced by acute β-adrenergic receptor stimulation in neonatal mouse cardiomyocytes.

    abstract：:Reactive oxygen species (ROS) play a crucial role in various physiological and pathological processes mediated by β-adrenergic receptors (β-ARs) in cardiomyocytes. However, the sources and signaling pathways involved in ROS production induced by acute β-AR activation have not yet been fully defined. In primary neonata...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.140

    authors： Zhang J,Xiao H,Shen J,Wang N,Zhang Y

    更新日期：2017-08-05 00:00:00

  • Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.

    abstract：:As the development of sequencing technology, more and more circular RNAs (circRNAs) are identified in human cancer tissues. Increasing evidences imply circRNAs are important regulators in tumor progression. Nevertheless, how circRNAs participate in breast cancer development and progression is not well understood. In t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.166

    authors： Liu Y,Lu C,Zhou Y,Zhang Z,Sun L

    更新日期：2018-07-20 00:00:00

  • Expression profile analysis of colon cancer cells in response to sulindac or aspirin.

    abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) have a preventive effect against colorectal cancer. Although inhibition of cyclooxygenase-2 plays a crucial role in the suppression of tumors, precise mechanisms of their action remain to be disclosed. To identify genes involved in the growth-suppressive effect of NSAIDs, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6648

    authors： Iizaka M,Furukawa Y,Tsunoda T,Akashi H,Ogawa M,Nakamura Y

    更新日期：2002-03-29 00:00:00

  • Thromboxane A2 receptor linked with the Ca2+ pathway in rat colonic crypt cells.

    abstract：:To clarify the presence of thromboxane A2 (TXA2) receptor in the colonic epithelium, we examined the effect of 9,11-epithio-11, 12-methano-thromboxane A2 (STA2), a stable analogue of TXA2, on intracellular free Ca2+ concentration ([Ca2+]i) of indo-1-loaded single cells in isolated rat colonic crypts by laser confocal ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0674

    authors： Ikari A,Sakai H,Sato T,Takeguchi N

    更新日期：1999-05-19 00:00:00

  • The effect of myotonic dystrophy transcript levels and location on muscle differentiation.

    abstract：:In myotonic dystrophy type I (DM1), nuclear retention of mutant DMPK transcripts compromises muscle cell differentiation. Although several reports have identified molecular defects in myogenesis, it remains still unclear how exactly the retention of the mutant transcripts induces this defect. We have recently created ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.031

    authors： Mastroyiannopoulos NP,Chrysanthou E,Kyriakides TC,Uney JB,Mahadevan MS,Phylactou LA

    更新日期：2008-12-12 00:00:00

  • Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.

    abstract：:This study aims to investigate the clinical significance and biological function of RASSF6 in human breast cancers. RASSF6 protein was found to be downregulated in 42 of 95 human breast cancer tissues by immunohistochemistry, which was associated with advanced TNM stage and nodal metastasis. The rate of RASSF6 downreg...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.159

    authors： He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

    更新日期：2018-09-18 00:00:00

  • Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart.

    abstract：RATIONALE:Islet-1 positive (Islet-1(+)) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta and pulmonary arte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.074

    authors： Weinberger F,Mehrkens D,Starbatty J,Nicol P,Eschenhagen T

    更新日期：2015-01-02 00:00:00

  • Effect of ATP binding cassette/multidrug resistance proteins on ATP efflux of Saccharomyces cerevisiae.

    abstract：:Multidrug resistance (MDR) in mammalian tumors or tissues is often associated with the overexpression of the putative drug efflux pump P-glycoprotein (Pgp). One theory concerning the mechanism of Pgp activity is that efflux of ATP is coupled to drug efflux. Evidence in support of this theory has been observed in mamma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5913

    authors： Boyum R,Guidotti G

    更新日期：1997-01-03 00:00:00

  • Functional characterization of T7 and T8 of human apolipoprotein (a).

    abstract：:Lipoprotein (a) [Lp(a)], a risk factor for coronary artery disease, is a LDL-like particle with apolipoprotein (a) [apo(a)] covalently linked to apolipoprotein B (apoB). Apo(a) has many repeats of kringle 4-like domain, classified as type 1 through type 10 (T1-T10). Deletion analysis was performed to define the functi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9478

    authors： Trieu VN,McConathy WJ

    更新日期：1998-10-09 00:00:00

  • Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.

    abstract：:Apigenin, a plant flavonoid, induced the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at a quite low concentration of 12.5 microM. In the present study, we have examined the components of this Ras-mediated signaling transduction to determine whether they were involved in the apigenin-induce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2035

    authors： Kuo ML,Yang NC

    更新日期：1995-07-26 00:00:00

  • LncRNA MALAT1 promotes cell proliferation and imatinib resistance by sponging miR-328 in chronic myelogenous leukemia.

    abstract：BACKGROUND:Chronic myeloid leukemia (CML) is a type of cancer that starts in certain blood-forming cells of the bone marrow. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well known protooncogene, has be shown to be upregulated in various tumor types, including multiple myeloma. However, the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.09.034

    authors： Wen F,Cao YX,Luo ZY,Liao P,Lu ZW

    更新日期：2018-12-09 00:00:00

  • Bile acids of patients with renal failure (possibility of bile acid secretion in the distal tubule).

    abstract：:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80699-5

    authors： Yamaga N,Adachi K,Kohara H,Shimizu K

    更新日期：1988-04-15 00:00:00

  • Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet.

    abstract：:The role of inducible nitric oxide synthase (iNOS) in the progression of fibrosis during nonalcoholic steatohepatitis remains to be elucidated. This study examined the role of iNOS in the progression of fibrosis during steatohepatitis by comparing iNOS knockout (iNOS(-/-)) and wild-type (iNOS(+/+)) mice that were fed ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.202

    authors： Chen Y,Hozawa S,Sawamura S,Sato S,Fukuyama N,Tsuji C,Mine T,Okada Y,Tanino R,Ogushi Y,Nakazawa H

    更新日期：2005-01-07 00:00:00

  • 7,8-Dihydroxyflavone ameliorates high-glucose induced diabetic apoptosis in human retinal pigment epithelial cells by activating TrkB.

    abstract：BACKGROUND:In diabetic retinopathy, prolonged high-level blood glucose induced significant impairments among various retinal tissues, including retinal pigment epithelial (RPE) cells. In an in vitro model of human RPE cells, we evaluated whether 7,8-Dihydroxyflavone (DHF) may effectively prevent high glucose-induced di...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.007

    authors： Yu X,Liu Q,Wang X,Liu H,Wang Y

    更新日期：2018-01-01 00:00:00

  • Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.

    abstract：:The uncharacterized Saccharomyces cerevisiae proteins Fcf1 and Fcf2, encoded by the ORFs YDR339c and YLR051c, respectively, were identified in a tandem affinity purification experiment of the known 40S factor Faf1p. Most of the proteins associated with TAP-Faf1p are trans-acting factors involved in pre-rRNA processing...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.05.140

    authors： Rempola B,Karkusiewicz I,Piekarska I,Rytka J

    更新日期：2006-07-28 00:00:00

  • Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition.

    abstract：:To investigate molecular mechanisms linking inflammation with neurodegeneration, we treated neuronal cultures with prostaglandins (PGs), which are mediators of inflammation. PGA1, D2, J2, and Delta12-PGJ2, but not PGE2, reduced the viability and raised the levels of ubiquitinated proteins in the neuronal cells. PGJ2 a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.098

    authors： Li Z,Melandri F,Berdo I,Jansen M,Hunter L,Wright S,Valbrun D,Figueiredo-Pereira ME

    更新日期：2004-07-09 00:00:00

  • Human cellular src gene product: identification of the myristoylated pp60c-src and blockage of its myristoyl acylation with N-fatty acyl compounds resulted in the suppression of colony formation.

    abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80870-8

    authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

    更新日期：1990-12-31 00:00:00

  • Heparin increases mRNA levels of thrombospondin but not fibronectin in human vascular smooth muscle cells.

    abstract：:The effects of heparin (180 micrograms/ml) on steady state mRNA levels for fibronectin, thrombospondin, actin and collagen types I and III were investigated in human umbilical artery smooth muscle cells. Heparin caused a 120% increase in thrombospondin mRNA levels and a 60% and 180% increase in the mRNA levels of proc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90786-9

    authors： Lyons-Giordano B,Brinker JM,Kefalides NA

    更新日期：1989-08-15 00:00:00

  • Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine.

    abstract：:Intranuclear inclusions have been observed in the brains of patients affected with Huntington's disease (HD). Neuro 2A cells that transiently expressed HD exon 1 bearing 74 glutamine repeats linked to the green fluorescent protein (GFP) and the nuclear localization sequence (NLS) contained aggregates in nuclei. The ag...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00498-9

    authors： Hazeki N,Tsukamoto T,Yazawa I,Koyama M,Hattori S,Someki I,Iwatsubo T,Nakamura K,Goto J,Kanazawa I

    更新日期：2002-06-07 00:00:00

  • RVX-297- a novel BD2 selective inhibitor of BET bromodomains.

    abstract：:Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.021

    authors： Kharenko OA,Gesner EM,Patel RG,Norek K,White A,Fontano E,Suto RK,Young PR,McLure KG,Hansen HC

    更新日期：2016-08-12 00:00:00

  • High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome.

    abstract：:Highly reliable biomarkers for the diagnosis of neurological diseases are not widely available. Here we evaluated a luciferase immunoprecipitation technology (LIPS) for the diagnosis of a CNS autoimmune disorder, stiff-person syndrome (SPS). Analysis by LIPS of 40 sera samples from SPS and control subjects for anti-GA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.077

    authors： Burbelo PD,Groot S,Dalakas MC,Iadarola MJ

    更新日期：2008-02-01 00:00:00

  • Functional evidence that the self-renewal gene NANOG regulates esophageal squamous cancer development.

    abstract：:Cancer cell molecular mimicry of stem cells (SC) follows with enhanced proliferative and renewal capacities. In support, numerous mediators of SC self-renewal have been evinced to exhibit oncogenic potential. More and more researches showed that the embryonic stem cell self-renewal genes express in various cancer cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.016

    authors： Deng L,Xiang X,Yang F,Xiao D,Liu K,Chen Z,Zhang R,Feng G

    更新日期：2017-08-19 00:00:00

  • Analysis by in vitro mutagenesis of PP2A alpha okadaic acid responsive sequences.

    abstract：:It has been shown that the protein serine/threonine phosphatase type 2A alpha catalytic subunit (PP2A alpha) has a mutation consisting of a glycine substitution for cysteine at 269 in the okadaic acid resistant variant of CHO cells, and that the mutant protein is resistant to okadaic acid (Shima, H. et al. Proc. Natl....

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2317

    authors： Kaneko S,Shima H,Amagasa T,Takagi M,Sugimura T,Nagao M

    更新日期：1995-09-14 00:00:00

  • Identification of binding domains for basic fibroblast growth factor in proteoglycan macrophage colony-stimulating factor.

    abstract：:We recently demonstrated that proteoglycan macrophage colony-stimulating factor (PG-M-CSF) binds basic fibroblast growth factor (bFGF) and neutralizes the biological activity of bFGF. In this study, we identified the binding sites of PG-M-CSF for bFGF. We examined the binding of bFGF to overlapping 12-mer peptides wit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5968

    authors： Suzu S,Kimura F,Matsumoto H,Yamada M,Hashimoto K,Shimamura S,Motoyoshi K

    更新日期：1997-01-13 00:00:00

  • Molecular cloning of cDNA for rat glycine methyltransferase.

    abstract：:Using a highly purified preparation of glycine methyltransferase mRNA, double-stranded cDNA was synthesized and inserted into the PstI site of pBR322. The resulting recombinant DNA was used to transform E. coli X 1776 by conventional methods. Among tetracycline-resistant transformants, a number of colonies were found ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90913-6

    authors： Ogawa H,Gomi T,Horii T,Ogawa H,Fujioka M

    更新日期：1984-10-15 00:00:00

  • Drosophila melanogaster larval hemolymph protein mapping.

    abstract：:With the completion of the genome sequence of Drosophila melanogaster the importance of constructing a proteome map is to be considered. Therefore, with the application of recent advances in proteomic analysis approaches, a protein map of D. melanogaster larvae hemolymph proteins was obtained using 2-DE in the range o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.10.156

    authors： Guedes Sde M,Vitorino R,Tomer K,Domingues MR,Correia AJ,Amado F,Domingues P

    更新日期：2003-12-19 00:00:00

  • Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.

    abstract：:We investigated the possible involvement of neuromedin U (NMU) and neuromedin S (NMS) in thermoregulation in rats. Intracerebroventricular (icv) injection of NMU or NMS increased the back surface temperature (BS-T) in a dose-dependent manner during both the light and dark periods. Pre-treatment with the β3 blocker SR5...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.155

    authors： Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

    更新日期：2016-02-19 00:00:00

  • AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice.

    abstract：:Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the functi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.003

    authors： Kim M,Au E,Neve R,Yoon BJ

    更新日期：2009-01-30 00:00:00

  • The ferrous-oxy complex of human aromatase.

    abstract：:In this communication, we document the self-assembly of heterologously expressed truncated human aromatase (CYP19) into nanometer scale phospholipids bilayers (Nanodiscs). The resulting P450 CYP19 preparation is stable and can tightly associate with the substrate androstenedione to form a nearly complete high-spin fer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.011

    authors： Grinkova YV,Denisov IG,Waterman MR,Arase M,Kagawa N,Sligar SG

    更新日期：2008-07-25 00:00:00

  • Isolation of a keto sugar specific agglutinin from rat uterus.

    abstract：:A ketosugar-specific agglutinin has been identified and purified to apparent homogeneity by affinity chromatography from the three days post-coital rat uterus. This protein is not found in other stages of estrous cycle. The agglutinin is glycoprotein, moves as single band with molecular weight 37,000 in polyacrylamide...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90884-3

    authors： Chowdhury M

    更新日期：1986-04-14 00:00:00