Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.

abstract：:We have previously shown that a ribozyme directed against human interleukin-6 (IL-6) mRNA is efficient in vivo, despite its poor activity in vitro on full-length IL-6 mRNA. We compared the effect of the nucleocapsid protein of HIV-1 (NCp7) on the ribozyme cleavage reaction of a long (1041 nt) and a short (19 nt) subst...

journal_title：Biochemical and biophysical research communications

authors： Mahieu M,Hendrix C,Ooms J,Herdewijn P,Content J

更新日期：1995-09-05 00:00:00

abstract：:The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH. The addition of Benzo(a)pyrene, 3-Methyl cholanthrene, beta-Naphthoflavone and other aryl hydrocarbons during the inductio...

journal_title：Biochemical and biophysical research communications

authors： Dutta D,Ghosh DK,Mishra AK,Samanta TB

更新日期：1983-09-15 00:00:00

abstract：:Small ubiquitin-like modifiers (SUMOs) are proteins homologous to ubiquitin that possibly regulate intranuclear protein localization, nuclear transport, and ubiquitination. We examined patients of DRPLA, SCA1, MJD, and Huntington's disease and found that neurons in affected regions of the brain react strongly to SUMO-...

journal_title：Biochemical and biophysical research communications

authors： Ueda H,Goto J,Hashida H,Lin X,Oyanagi K,Kawano H,Zoghbi HY,Kanazawa I,Okazawa H

更新日期：2002-04-26 00:00:00

abstract：:We have previously demonstrated that antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier inhibited neurite outgrowth in NB2a/d1 neuroblastoma cells, and that culturing of these cells on adhesive substrates such as laminin or poly-L-lysine overcame this restriction. The...

journal_title：Biochemical and biophysical research communications

authors： Shea TB

更新日期：1994-08-30 00:00:00

abstract：:The exposure of hydrophobic sites on calmodulin, skeletal muscle troponin C and their tryptic fragments was investigated using Phenyl-Sepharose chromatography. A strong binding of both proteins and their fragments corresponding to the NH2-terminal halves of polypeptide chain of respective proteins in the presence of c...

journal_title：Biochemical and biophysical research communications

authors： Brzeska H,Szynkiewicz J,Drabikowski W

更新日期：1983-08-30 00:00:00

abstract：:Nrf2 is a key regulator of many detoxifying enzyme genes, and cytoplasmic protein Keap1 represses the Nrf2 activity under quiescent conditions. Germ line deletion of the keap1 gene results in constitutive activation of Nrf2, but the pups unexpectedly died before weaning. To investigate how constitutive activation of N...

journal_title：Biochemical and biophysical research communications

authors： Okawa H,Motohashi H,Kobayashi A,Aburatani H,Kensler TW,Yamamoto M

更新日期：2006-01-06 00:00:00

abstract：:Streptococcus mutans secretes a sucrose-independent branalphang enzyme that utilizes isomaltosaccharides as donors for branalphang formation on dextran. Although the branching enzyme is necessary for the formation of extracellular polysaccharide complexes, the source of the donor for the enzyme is unknown. In this stu...

journal_title：Biochemical and biophysical research communications

authors： Yamashita Y,Hanada N,Takehara T

更新日期：1988-01-29 00:00:00

abstract：:The factors responsible for up-regulation of PTP1B, a negative regulator of insulin signaling, in insulin resistance state are not well understood. We performed a series of experiments in C2C12 muscle cells to determine the role of palmitate and an inflammatory state in regulation of PTP1B. Palmitate (0.75mM) induced ...

journal_title：Biochemical and biophysical research communications

authors： Parvaneh L,Meshkani R,Bakhtiyari S,Mohammadtaghvaie N,Gorganifiruzjaee S,Taheripak G,Golestani A,Foruzandeh M,Larijani B,Taghikhani M

更新日期：2010-05-28 00:00:00

abstract：:GMP-140 (CD62; PADGEM) is a member of the selectin family expressed highly at the surface of platelets and endothelial cells by agonists such as thrombin or phorbol esters. Previous studies indicate that the lectin domain of GMP-140 recognizes sialosyl-Le(x) (SLex) and to a lesser extent Le(x) (Polley MJ, et al., Proc...

journal_title：Biochemical and biophysical research communications

authors： Handa K,Nudelman ED,Stroud MR,Shiozawa T,Hakomori S

更新日期：1991-12-31 00:00:00

abstract：:Interleukin 6 is a pleiotropic cytokine produced in the central nervous system (CNS) that has been involved in both direct neurotrophic activities and in the regulation of the production of acute phase proteins both at peripheral and central levels. In rat cortical type I astrocytes, interleukin 6 release is under the...

journal_title：Biochemical and biophysical research communications

authors： Grimaldi M,Florio T,Schettini G

更新日期：1997-06-09 00:00:00

abstract：:We have synthesized the first enkephalin analog containing a "cyclopropyl" phenylalanine (Phe) residue. The E-configuration of this residue is apparently responsible for its low activity in the MVD and GPI muscle assays. The enkephalin is very stable to cleavage by carboxypeptidase Y. ...

journal_title：Biochemical and biophysical research communications

authors： Kimura H,Stammer CH,Shimohigashi Y,Ren-Lin C,Stewart J

更新日期：1983-08-30 00:00:00

abstract：:The distribution, labeling and interrelationship of microsomal and lysosomal dolichol and dolichyl-P in rat liver was investigated. After membrane induction with phenobarbital, N-nitrosodiethylamine and diethylhexylphthalate, the amount of microsomal and lysosomal dolichols are modulated independently. Liposomal label...

journal_title：Biochemical and biophysical research communications

authors： Edlund C,Chojnacki T,Dallner G

更新日期：1983-09-30 00:00:00

abstract：:We used fluorescence correlation spectroscopy (FCS) to study the activation of fibrinogen by thrombin and the subsequent aggregation of fibrin monomers into fibrin polymers at a very low and at physiological fibrinogen concentrations. In the labeling procedure used the fibrinogen was randomly labeled and the label was...

journal_title：Biochemical and biophysical research communications

authors： Bark N,Földes-Papp Z,Rigler R

更新日期：1999-06-24 00:00:00

abstract：:TRAF2 is a key molecule involved in TNF signaling, which is crucial for the regulation of inflammatory processes. We have identified a novel TRAF2 binding protein, designated as T2BP (TRAF2 binding protein), by a mammalian two-hybrid screening approach. T2BP is a relatively small protein of 184 amino acids, which incl...

journal_title：Biochemical and biophysical research communications

authors： Kanamori M,Suzuki H,Saito R,Muramatsu M,Hayashizaki Y

更新日期：2002-01-25 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a cancer arising from the nasopharynx epithelium. Long non-coding RNAs (lnc RNA) play a critical role in various biological processes such as cell growth, embryonic development, and tumorigenesis. In the study, for the first time, we discovered that lnc RNA taurine upregulated gene 1 ...

journal_title：Biochemical and biophysical research communications

authors： Qian W,Ren Z,Lu X

更新日期：2019-01-29 00:00:00

abstract：:Enterovirus 71 (EV71) has led to recent outbreaks of hand, foot and mouth disease (HFMD) in China, resulting in high mortality. In this study, several monoclonal antibodies were generated by immunizing mice with two synthetic peptides, SP55 and SP70, containing amino acids 163-177 and 208-222 of VP1. The specificities...

journal_title：Biochemical and biophysical research communications

authors： Li X,Mao C,Ma S,Wang X,Sun Z,Yi Y,Guo M,Shen X,Sun L,Bi S

更新日期：2009-12-25 00:00:00

abstract：:Ceramide acts as a second messenger and modulates many cellular functions. This molecule can be produced by enzymatic digestion of sphingomyelin, a phospholipid which has been shown to be in high concentration in a chromatin phospholipidic fraction. In order to clarify whether chromatin sphingomyelin has a role in thi...

journal_title：Biochemical and biophysical research communications

authors： Albi E,Magni MP

更新日期：1997-07-09 00:00:00

abstract：OBJECTIVE:The objective of this study was to construct a recombinant vector expressing siRNA targetedly inhibiting aquaporin 3 (AQP3), and to evaluate the effects of AQP3 inhibition on the proliferation and invasion of XWLC-05 human lung cancer cells. METHODS:We obtained human AQP3 sequence from the Genbank and establ...

journal_title：Biochemical and biophysical research communications

authors： Xiong G,Chen X,Zhang Q,Fang Y,Chen W,Li C,Zhang J

更新日期：2017-04-08 00:00:00

abstract：:Human dendritic cells (DC) are key regulators of innate and adaptive immunity that can be divided in at least three major subpopulations: plasmacytoid DC (pDC), myeloid type 1 DC (mDC1) and myeloid type 2 DC (mDC2) exhibiting different functions. However, research, diagnostic and cell therapeutic studies on human DC s...

journal_title：Biochemical and biophysical research communications

authors： Schütz F,Hackstein H

更新日期：2014-01-10 00:00:00

abstract：:The Forkhead/Fox transcription factor Foxc2 is a critical regulator of vascular development. However, the role of Foxc2 in pathological angiogenesis in cancer remains unknown. Here we show that FoxC2 is highly expressed in human breast and colonic tumors and in the tumor endothelium in human and mouse melanomas. Using...

journal_title：Biochemical and biophysical research communications

authors： Sano H,Leboeuf JP,Novitskiy SV,Seo S,Zaja-Milatovic S,Dikov MM,Kume T

更新日期：2010-02-05 00:00:00

abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

journal_title：Biochemical and biophysical research communications

authors： Mulder E,Vrij AA,Brinkmann AO

更新日期：1983-08-12 00:00:00

abstract：:Using a novel approach for analysis of TRPC channel activity, we report here that NSAIDs are involved into regulation of TRPC channels in the podocytes of the freshly isolated decapsulated glomeruli. Fluorescence and electron microscopy techniques confirmed the integrity of podocytes in the glomeruli. Western blotting...

journal_title：Biochemical and biophysical research communications

authors： Ilatovskaya DV,Levchenko V,Ryan RP,Cowley AW Jr,Staruschenko A

更新日期：2011-05-06 00:00:00

abstract：:Phosphoinositide phospholipase C (PLC) was extracted from the synaptic membrane fraction of rat brain by 1% sodium deoxycholate. The molecular weight and sedimentation coefficient of the membrane PLC were about 160,000 and 6.7 as estimated by gel filtration and sucrose density gradient centrifugation, respectively. Th...

journal_title：Biochemical and biophysical research communications

authors： Kozawa O,Hoshijima M,Tanimoto T,Ohmori T,Takai Y

更新日期：1987-05-29 00:00:00

abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

journal_title：Biochemical and biophysical research communications

authors： Malina HZ,Frueh BE

更新日期：2003-10-17 00:00:00

abstract：:In the presence of endothelin, there was a rapid increase in the 45Ca++ efflux from primary cultured rat vascular smooth muscle cells, both in physiological salt solution and in calcium free medium containing 2 mM EGTA. The 45Ca++ influx was not affected. The endothelin-induced, transient increase in cytosolic calcium...

journal_title：Biochemical and biophysical research communications

authors： Miasiro N,Yamamoto H,Kanaide H,Nakamura M

更新日期：1988-10-14 00:00:00

abstract：:Collagens are the most abundant structural proteins found in the extracellular matrix of vertebrates. Knowledge of the mechanical behavior of collagen monomers is essential for understanding the mechanical properties of collagen fibrils that constitute the main architectural framework of skin, bone, cartilage, and oth...

journal_title：Biochemical and biophysical research communications

authors： Sun YL,Luo ZP,Fertala A,An KN

更新日期：2002-07-12 00:00:00

abstract：:The amino acid sequence of biliverdin-IX beta reductase (EC1.3.1.24) from human liver was determined by automated Edman degradation of peptides generated by enzymatic and chemical cleavages. The enzyme was a single polypeptide chain of 204 amino acid residues, and its amino acid sequence had no significant homology to...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Komuro A,Nakano Y,Tomita M,Nakajima H

更新日期：1993-12-30 00:00:00

abstract：:Nucleolar protein p40/EBP2 is a proliferation-associated antigen that interacts with Epstein-Barr virus nuclear antigen 1 (EBNA1) to maintain the Epstein-Barr virus (EBV) episomes. The yeast p40/EBP2 functions in the processing of 27S-A into 27S-B ribosomal RNA. The present study reports high evolutionary conservation...

journal_title：Biochemical and biophysical research communications

authors： Henning D,Valdez BC

更新日期：2001-05-04 00:00:00

abstract：:Calcitonin is a key hormone involved in the regulation of calcium metabolism in vertebrates. Using oligonucleotide primers derived from consensus sequences of vertebrate calcitonin receptors, we have cloned and characterized the first representative of an invertebrate calcitonin receptor from the bivalve mollusc Crass...

journal_title：Biochemical and biophysical research communications

authors： Dubos MP,Badariotti F,Rodet F,Lelong C,Favrel P

更新日期：2003-10-24 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00