Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.

abstract：:We describe the isolation of a synthetic agonist of IFN-gamma (L-mIFN-gamma-CT) active on mouse and human cells. Its biological activity is the result of the ability of the C-terminal extremity of murine IFN-gamma to interact with the intracellular part of IFNgamma-R and the observation that the modification of peptid...

journal_title：Biochemical and biophysical research communications

authors： Thiam K,Loing E,Delanoye A,Diesis E,Gras-Masse H,Auriault C,Verwaerde C

更新日期：1998-12-30 00:00:00

abstract：:We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a h...

journal_title：Biochemical and biophysical research communications

authors： Gantz I,Shimoto Y,Konda Y,Miwa H,Dickinson CJ,Yamada T

更新日期：1994-05-16 00:00:00

abstract：:Dietary supplementation with coenzyme Q (CoQ) has been proposed to have anti-atherogenic effects by virtue of its antioxidant capacity. To investigate this question, the leukocyte status of 5 males and 5 females (52-68 years) was evaluated before and after supplementation with 200mg CoQ/day for 5 and 10 weeks. CoQ was...

journal_title：Biochemical and biophysical research communications

authors： Turunen M,Wehlin L,Sjöberg M,Lundahl J,Dallner G,Brismar K,Sindelar PJ

更新日期：2002-08-16 00:00:00

abstract：:TGFbeta is of crucial importance during transdifferentiation of resting retinoid-storing hepatic stellate cells (HSC) to extracellular matrix producing myofibroblasts (MFB) and consequently, inhibition of TGFbeta signal transduction is an effective means for preventing experimental fibrosis. We have shown that isolate...

journal_title：Biochemical and biophysical research communications

authors： Dooley S,Streckert M,Delvoux B,Gressner AM

更新日期：2001-05-11 00:00:00

abstract：:In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using...

journal_title：Biochemical and biophysical research communications

authors： Kajikawa N,Kaibuchi K,Matsubara T,Kikkawa U,Takai Y,Nishizuka Y,Itoh K,Tomioka C

更新日期：1983-10-31 00:00:00

abstract：:Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes. Co-immunoprecipitation experiments performed on Jurkat cells, showed that Tip60 is present in the same macro-molecular complex as UHR...

journal_title：Biochemical and biophysical research communications

authors： Achour M,Fuhrmann G,Alhosin M,Rondé P,Chataigneau T,Mousli M,Schini-Kerth VB,Bronner C

更新日期：2009-12-18 00:00:00

abstract：:Angiotensin (Ang) II, via type 1 receptor activation, exerts a significant role in atherogenesis and collagen synthesis. To test the hypothesis that Ang II type 2 receptor (AT2R) upregulation delivered with adeno-associated virus type 2 (AAV/AT2R) would inhibit collagen synthesis in atherosclerotic arteries, LDLR knoc...

journal_title：Biochemical and biophysical research communications

authors： Dandapat A,Hu CP,Chen J,Liu Y,Khan JA,Remeo F,Carey RM,Hermonat PL,Mehta JL

更新日期：2008-02-22 00:00:00

abstract：:The results presented in this paper demonstrate that the potentiation of phagocytosis of erythrocyte (E) IgG by TNF-alpha or PMA is not due to an oxygen-dependent mechanism. In fact, the potentiation of phagocytosis occurs normally in human neutrophils 1) when the respiratory burst is inhibited by diphenyleneiodonium,...

journal_title：Biochemical and biophysical research communications

authors： Della Bianca V,Grzeskowiak M,Renzi E,Rossi F

更新日期：1993-06-30 00:00:00

abstract：:The mechanism(s) by which HIV-1 infection contributes to depletion of CD4(+) T cell is not well understood. In this report, we investigated whether a recently identified isoform of growth factor receptor bound protein (Grb2), named Grb3-3, a signaling molecule that is associated with the MAP kinase pathway and with ap...

journal_title：Biochemical and biophysical research communications

authors： Li X,Multon MC,Henin Y,Schweighoffer F,Venot C,LaVecchio J,Josef J,Stuckert P,Mhashilkar A,Tocqué B,Marasco WA

更新日期：2000-09-16 00:00:00

abstract：:This report examines the balance of positive and negative adipogenic factors in a line of immortalized 243 embryonic fibroblasts that undergo spontaneous preadipocyte differentiation. Control of adipogenesis reflects the interplay of factors that promote or inhibit expression of C/EBPalpha and PPARgamma. The 243 cells...

journal_title：Biochemical and biophysical research communications

authors： Bennett CN,Hodge CL,MacDougald OA,Schwartz J

更新日期：2003-02-28 00:00:00

abstract：:The expression of sucrase-isomaltase mRNA was investigated along the crypt-villus axis of rat small intestine using differentially isolated cells and in situ hybridization. A partial rat sucrase-isomaltase cDNA was cloned which coded for a protein that was predicted to be 88% homologous to those encoded by the rabbit ...

journal_title：Biochemical and biophysical research communications

authors： Traber PG

更新日期：1990-12-31 00:00:00

abstract：:Alkaline elastase YaB, produced by alkalophilic Bacillus YaB, is an extracellular serine protease having 55% homology to subtilisin BPN' and thus could be called subtilisin YaB. It is synthesized as a 378-amino acid preproenzyme and secreted into the culture medium as a 265-amino acid mature protease. To examine if th...

journal_title：Biochemical and biophysical research communications

authors： Chang YC,Kadokura H,Yoda K,Yamasaki M

更新日期：1996-02-15 00:00:00

abstract：:Transformation of fluorene by washed cells of fluorene-grown Pseudomonas sp. F274 yielded 1,la-dihydroxy-1-hydrofluoren-9-one (up to 100 mg/l) as the stable product of angular dioxygenation of 9-fluorenone. Structural identity of the angular keto-diol was established by 13C- and 1H-NMR, gas chromatography- and direct ...

journal_title：Biochemical and biophysical research communications

authors： Selifonov SA,Grifoll M,Gurst JE,Chapman PJ

更新日期：1993-05-28 00:00:00

abstract：:The gut epithelium is critically involved in maintaining intestinal immune homeostasis. Acting as a physical barrier, it separates the intestinal microflora from cells of the immune system. In addition to its barrier function, the intestinal epithelium expresses defensins, natural, endogenous antimicrobial peptides. I...

journal_title：Biochemical and biophysical research communications

authors： Zhao A,Lu W,de Leeuw E

更新日期：2015-11-27 00:00:00

abstract：:Human respiratory syncytial virus (RSV) non-structural protein 1 (NS1) has recently been suggested to inhibit type-I interferon (IFN)-dependent immune responses during RSV infection. However, the precise function of RSV NS1 protein in reducing the antiviral effects of IFNs against RSV is poorly understood. The roles o...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Yang L,Wang H,Zhang G,Sun X

更新日期：2016-09-23 00:00:00

abstract：:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

更新日期：2012-02-24 00:00:00

abstract：:Rat serosal mast cells were tested for their ability to generate a nitric oxide-like factor by two bioassay systems: inhibition of platelet aggregation and stimulation of mast cell guanylate cyclase. Incubation of rat serosal mast cells with human washed platelets resulted in an inhibition of thrombin-induced platelet...

journal_title：Biochemical and biophysical research communications

authors： Salvemini D,Masini E,Anggard E,Mannaioni PF,Vane J

更新日期：1990-06-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cancer cells are usually insensitive to TRAIL so reducing this drug resistance may improve the treatment of gastric cancer. In thi...

journal_title：Biochemical and biophysical research communications

authors： Li H,Lv J,Guo J,Wang S,Liu S,Ma Y,Liang Z,Wang Y,Qi W,Qiu W

更新日期：2021-01-18 00:00:00

abstract：:The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm...

journal_title：Biochemical and biophysical research communications

authors： Neumivakin LV,Solovjev VP,Sokhansanj A,Tilba VA,Moseiko NA,Shachbasian RV,Piruzian ES

更新日期：1995-12-26 00:00:00

abstract：:By using a subtraction-enhanced display technique, we identified a cDNA clone representing alpha-prothymosin, from rat hepatocellular carcinoma (HCC). alpha-Prothymosin has been reported to be involved in cell proliferation and regulated by c-myc gene in vitro. In the present study, we investigated the gene expression...

journal_title：Biochemical and biophysical research communications

authors： Wu CG,Boers W,Reitsma PR,van Deventer SJ,Chamuleau RA

更新日期：1997-03-27 00:00:00

abstract：:Antibody against actin isolated from a human EBV-transformed lymphoblastoid B-cell line exerted an inhibitory effect on in vitro IgM secretion by a different lymphoblastoid B-cell line, LA350. This effect was dose dependent showing from 24-40% inhibition at a dilution of 1:100 and 68-80% inhibition at a dilution of 1:...

journal_title：Biochemical and biophysical research communications

authors： Rosenblatt HM,Green CG,McClure JE,Shearer WT

更新日期：1986-10-15 00:00:00

abstract：:Signal transduction by transforming growth factor-beta (TGF-beta) involves the formation of a heteromeric complex of two transmembrane serine/threonine kinase receptors, type I (T beta R-I) and type II (T beta R-II). In the region preceeding the kinase domain of T beta R-I there is a glycine- and serine-rich sequence,...

journal_title：Biochemical and biophysical research communications

authors： Franzén P,Heldin CH,Miyazono K

更新日期：1995-02-15 00:00:00

abstract：:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observe...

journal_title：Biochemical and biophysical research communications

authors： Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

更新日期：2014-01-10 00:00:00

abstract：:Recently a rabbit cDNA (F3R) was characterized as binding and causing calcium mobilization induced by the formyl-methionine-leucine-phenylalanine peptide (fMLP). In the study reported here, cloned DNAs were isolated from rabbit genomic DNA by PCR based on the sequence of F3R. The cloned DNAs have several differences i...

journal_title：Biochemical and biophysical research communications

authors： Beckmann MP,Munger WE,Kozlosky C,VandenBos T,Price V,Lyman S,Gerard NP,Gerard C,Cerretti DP

更新日期：1991-09-16 00:00:00

abstract：:The product of the spontaneous dimerization and decarboxylation of aminoethylcysteine ketimine (simply named the dimer in this note) has been investigated for a possible biochemical activity. It has been found that the dimer inhibits the ADP-dependent oxidation of NAD(+)-linked substrates in rat liver mitochondria and...

journal_title：Biochemical and biophysical research communications

authors： Pecci L,Montefoschi G,Fontana M,Cavallini D

更新日期：1994-03-15 00:00:00

abstract：:The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 ...

journal_title：Biochemical and biophysical research communications

authors： Thompson KA,Wang B,Argraves WS,Giancotti FG,Schranck DP,Ruoslahti E

更新日期：1994-02-15 00:00:00

abstract：:Using in vitro assays, we show that nuclear proteins related to the Sp1 and GT-1 factors bind to a CACCC box sequence in the human beta-globin enhancer, adjacent to binding sites for the erythroid-specific factor NFE1 and the ubiquitous factor CP1. The same proteins are known to bind to the proximal, but not to the di...

journal_title：Biochemical and biophysical research communications

authors： Giglioni B,Comi P,Ronchi A,Mantovani R,Ottolenghi S

更新日期：1989-10-16 00:00:00

abstract：:The estrogen synthetase (aromatase, cytochrome P-450AROM) gene has been isolated from human genomic libraries and characterized. The restriction map of 43 positive clones obtained indicated that this enzyme is present as a single copy gene. The aromatase gene is unexpectedly large compared with other forms of the cyto...

journal_title：Biochemical and biophysical research communications

authors： Harada N,Yamada K,Saito K,Kibe N,Dohmae S,Takagi Y

更新日期：1990-01-15 00:00:00

abstract：:Nitric oxide synthase (EC 1.14.23) substrate analog inhibitors NG-monomethyl-L-Arg, NG-nitro-L-Arg, NG-nitro-L-Arg methyl ester, and aminoguanidine were examined as potential inhibitors of rat liver arginase (EC 3.5.3.1). NG-nitro-L-Arg was found to inhibit arginase catalyzed conversion of L-Arg to L-Orn at pH 7.5 wit...

journal_title：Biochemical and biophysical research communications

authors： Robertson CA,Green BG,Niedzwiecki L,Harrison RK,Grant SK

更新日期：1993-12-15 00:00:00

abstract：:In this study, naloxone was tested for its antiplatelet activity in human platelet suspensions. In platelet suspensions (4.5 x 10(8)/ml), naloxone (0.1-0.5 mM) significantly inhibited platelet aggregation and ATP-release stimulated by various agonists (i.e., thrombin, collagen, U46619, and ADP). Furthermore, naloxone ...

journal_title：Biochemical and biophysical research communications

authors： Sheu JR,Hung WC,Lee LW,Chang PT,Kan YC,Yen MH

更新日期：1997-02-03 00:00:00