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Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase.

Abstract：

:Nitric oxide synthase (EC 1.14.23) substrate analog inhibitors NG-monomethyl-L-Arg, NG-nitro-L-Arg, NG-nitro-L-Arg methyl ester, and aminoguanidine were examined as potential inhibitors of rat liver arginase (EC 3.5.3.1). NG-nitro-L-Arg was found to inhibit arginase catalyzed conversion of L-Arg to L-Orn at pH 7.5 with an IC50 = 27.2 +/- 4.3 mM, compared to L-Val and L-Lys with IC50 values of 6.2 +/- 0.4 mM and 31.3 +/- 2.7 mM, respectively. Inhibition was stereospecific for the L-amino acid, not NG-nitro-D-Arg, and required a free alpha-carboxyl group. NG-nitro-L-Arg was not a substrate for rat liver arginase. These results suggest that arginase inhibition should also be evaluated when studying the effects of NOS substrate analog inhibitors in vivo.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Robertson CA,Green BG,Niedzwiecki L,Harrison RK,Grant SK

doi

10.1006/bbrc.1993.2510

subject

Has Abstract

pub_date

1993-12-15 00:00:00

pages

523-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72510-6

journal_volume

197

pub_type

杂志文章

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