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Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids.

Abstract：

:The major biological effects of glucocorticoids are thought to be initiated through changes in the expression of cellular genes. However, the mechanisms involved in the suppression of some gene products by glucocorticoids are not well defined. ID13 mouse fibroblast cells were treated with the synthetic glucocorticoid dexamethasone (Dex) or with vehicle. Plus/ minus (+Dex/-Dex) cDNAs were used to screen an ID13 cDNA library. Using this method, we found that the recently identified human protein adenovirus E4 promoter binding protein (E4BP4) mRNA was induced by Dex in the ID13 cell line. E4BP4 is a transcriptional repressor and binds to a specific DNA element. Further investigation indentified E4BP4-like DNA elements located in the promoters of glucocorticoid repressed genes Cox-2, iNOS, and cPLA2. These findings suggest that E4BP4 may play a role in the glucocorticoid repression of these and other genes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wallace AD,Wheeler TT,Young DA

doi

10.1006/bbrc.1997.6206

subject

Has Abstract

pub_date

1997-03-17 00:00:00

pages

403-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96206-9

journal_volume

232

pub_type

杂志文章

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