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Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.

Abstract：

:A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-O-tetra-decanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nishino H,Fujiki H,Suganuma M,Horiuchi T,Iwashima A,Sugimura T

doi

10.1016/0006-291x(84)91018-0

subject

Has Abstract

pub_date

1984-11-14 00:00:00

pages

726-30

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91018-0

journal_volume

124

pub_type

杂志文章

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