Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells.

abstract：:There is considerable interest in the role of metals such as iron, copper, and zinc in amyloid plaque formation in Alzheimer's disease. However to convincingly establish their presence in plaques in vivo, a sensitive technique is required that is both quantitatively accurate and avoids isolation of plaques or staining...

journal_title：Biochemical and biophysical research communications

authors： Rajendran R,Minqin R,Ynsa MD,Casadesus G,Smith MA,Perry G,Halliwell B,Watt F

更新日期：2009-04-24 00:00:00

abstract：:Pelvic cartilage of chick embryo was used to demonstrate that presence of boron in culture medium decreases synthesis of proteoglycans, collagen and total proteins but on the other hand increases the release of these macromolecules. However, when glucose concentration in culture medium is brought to 22mM, the synthesi...

journal_title：Biochemical and biophysical research communications

authors： Benderdour M,Hess K,Gadet MD,Dousset B,Nabet P,Belleville F

更新日期：1997-05-08 00:00:00

abstract：:The stromal cell-derived factor-1α/C-X-C chemokine receptor 4 (SDF-1/CXCR4) axis is involved in various aspects of tissue repair, regeneration and development. However, the role of SDF-1/CXCR4 in acute lung injury (ALI) remains largely unknown. The aim of the present investigation is to examine pathological changes in...

journal_title：Biochemical and biophysical research communications

authors： Guo W,Li Z,Xie X,Tan T,Wang S,Xie N,Fu M,Zhu H,Qin T

更新日期：2014-09-12 00:00:00

abstract：:To explore the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in nociceptors, we developed a method that allows us to label nociceptive neurons innervating tooth-pulp in rat trigeminal ganglion (TG) neurons using a retrograde fluorescence-tracing method, to record ATP-activa...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Tian X,Wu Y,Chen L,Yi CL,Li ZW,Zhang Y,Li CY

更新日期：2015-03-13 00:00:00

abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

journal_title：Biochemical and biophysical research communications

authors： Sejimo S,Hossain MS,Akashi K

更新日期：2018-09-05 00:00:00

abstract：:Airway viral infection disturbs the health-related quality of life. B7-H1 (also known as PD-L1) is a coinhibitory molecule associated with the escape of viruses from the mucosal immunity, leading to persistent infection. Most respiratory viruses generate double-stranded (ds) RNA during replication. The stimulation of ...

journal_title：Biochemical and biophysical research communications

authors： Kan-o K,Matsumoto K,Asai-Tajiri Y,Fukuyama S,Hamano S,Seki N,Nakanishi Y,Inoue H

更新日期：2013-05-31 00:00:00

abstract：:Some mutations in mitochondrial DNA (mtDNA) causing a number of neuromuscular diseases are suggested to arise spontaneously during the life of an individual. To substantiate the extent and the rate of these somatic mutations, mtDNA specimens from post-mortem human heart muscles of subjects in differing age groups were...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hattori K,Sugiyama S,Ozawa T

更新日期：1992-12-15 00:00:00

abstract：:In addition to inhibiting matrix metalloproteinases, tissue inhibitor of metalloproteinase-1 (TIMP-1) is involved in the regulation of cell growth and survival. To determine its mechanism of action, we investigated effects of TIMP-1 on cell proliferation and survival and signaling pathways induced by TIMP-1 in the hum...

journal_title：Biochemical and biophysical research communications

authors： Lee SJ,Yoo HJ,Bae YS,Kim HJ,Lee ST

更新日期：2003-12-26 00:00:00

abstract：:Acid sensing ion channels (ASICs) are proton-gated cation channels that are expressed throughout the nervous system and have been implicated in mediating sensory perception of noxious stimuli. Amongst the six ASIC isoforms, ASIC1a, 1b, 2a and 3 form proton-gated homomers, which differ in their activation and inactivat...

journal_title：Biochemical and biophysical research communications

authors： Rahman T,Smith ES

更新日期：2014-07-18 00:00:00

abstract：:Regulation of gene expression in trypanosomatids is not yet well understood. Genes are organized in long polycistronic transcriptional units separated by intergenic regions that may contain the signaling information for nucleic acid processing. Poly-dinucleotides are frequent in these regions and have been proposed to...

journal_title：Biochemical and biophysical research communications

authors： Duhagon MA,Dallagiovanna B,Ciganda M,Ruyechan W,Williams N,Garat B

更新日期：2003-09-12 00:00:00

abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

journal_title：Biochemical and biophysical research communications

authors： Regen SL,Jayasuriya N,Fabianowski W

更新日期：1989-03-15 00:00:00

abstract：:Helodermin is a peptide from the venom of the lizard Heloderma suspectum (Gila Monster) showing a high degree of sequence similarity with VIP, PHI and secretin in its N-terminal moiety. The present data support the presence of peptide(s) closely related to helodermin in the brain, gut and salivary glands of rat. In ou...

journal_title：Biochemical and biophysical research communications

authors： Robberecht P,De Graef J,Woussen MC,Vandermeers-Piret MC,Vandermeers A,De Neef P,Cauvin A,Yanaihara C,Yanaihara N,Christophe J

更新日期：1985-07-16 00:00:00

abstract：:The proto-oncogene Akt is a potent inhibitor of apoptosis, and it is activated in many human cancers. A number of recent studies have highlighted the importance of the inositol 1,4,5-trisphosphate (IP3) receptor(IP3R) in mediating calcium (Ca2+) transfer from the endoplasmic reticulum (ER) to the mitochondriain severa...

journal_title：Biochemical and biophysical research communications

authors： Marchi S,Rimessi A,Giorgi C,Baldini C,Ferroni L,Rizzuto R,Pinton P

更新日期：2008-10-31 00:00:00

abstract：:Immediate-early genes (IEGs) are useful for mapping active brain regions in various vertebrates. Here we identified a c-fos homologue gene in medaka and demonstrated that the amounts of c-fos transcripts and proteins in the medaka brain increased in relation to an artificially evoked seizure, suggesting that the homol...

journal_title：Biochemical and biophysical research communications

authors： Okuyama T,Suehiro Y,Imada H,Shimada A,Naruse K,Takeda H,Kubo T,Takeuchi H

更新日期：2011-01-07 00:00:00

abstract：:HMGB1 (high-mobility group B1) is a ubiquitously expressed bifunctional protein that acts as a nuclear protein in cells and also as an inflammatory mediator in the extracellular space. HMGB1 changes its functions according to the redox states in both intra- and extra-cellular environments. Two cysteines, Cys23 and Cys...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Tochio N,Takeuchi A,Uewaki J,Kobayashi N,Tate S

更新日期：2013-11-29 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels assembled from four subunits that each have a common membrane topology. The intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least conserved between subunits, and binds multiple intracellular proteins. We defined ...

journal_title：Biochemical and biophysical research communications

authors： Bajaj G,Hau AM,Hsu P,Gafken PR,Schimerlik MI,Ishmael JE

更新日期：2014-02-21 00:00:00

abstract：:The aim of this study was to illustrate the further process of 24p3 protein after association with epididymal spermatozoa. We have previously identified a caput-initiated 24p3 protein, which interacts with the spermatozoa surface in vitro. In the present study, we investigate another role of the 24p3 protein with sper...

journal_title：Biochemical and biophysical research communications

authors： Elangovan N,Lee YC,Tzeng WF,Chu ST

更新日期：2004-07-09 00:00:00

abstract：:The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami. Their amino acid sequences are DDTEDLANKFIGLM-NH(2) (named tachyk...

journal_title：Biochemical and biophysical research communications

authors： Li J,Liu T,Xu X,Wang X,Wu M,Yang H,Lai R

更新日期：2006-12-01 00:00:00

abstract：:2-Hydroxy-5-nitrobenzyl bromide, a highly reactive reagent towards tryptophan residues in proteins, is shown to activate the passive proton flux through the inner mitochondrial membrane of bovine heart submitochondrial particles (ETPH). When added at low concentrations, the reagent increased both the ATPase activity o...

journal_title：Biochemical and biophysical research communications

authors： Solaini G,Baracca A,Parenti Castelli G,Rossi CA

更新日期：1988-08-30 00:00:00

abstract：:Single particle tracking (SPT) is a powerful technique for studying mRNA dynamics in cells. Although SPT of mRNA has been performed by labeling mRNA with fluorescent dyes or proteins, observation of mRNA for long durations with high temporal resolution has been difficult due to weak fluorescence and rapid photobleachi...

journal_title：Biochemical and biophysical research communications

authors： Ishihama Y,Funatsu T

更新日期：2009-03-27 00:00:00

abstract：:Our previous study on the dynamic transcriptomes activated during human erythropoiesis suggested that transcription factor forkhead box O3 (FOXO3) possibly plays a role in erythroid differentiation. Functional studies in human cell line TF-1 indicated that FOXO3 knockdown repressed erythropoietin (EPO)-induced erythro...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Li Y,Wang S,Zhang Q,Zheng J,Yang Y,Qi H,Qu H,Zhang Z,Liu F,Fang X

更新日期：2015-05-15 00:00:00

abstract：:To investigate the involvement of nitric oxide (NO) in the pathogenesis of the cardiovascular system with aging, we studied the basal release of NO in cultured endothelial cells isolated from normal human umbilical veins (HUVECs) at different population doubling levels (PDLs). The release of NO was assayed by a newly ...

journal_title：Biochemical and biophysical research communications

authors： Sato I,Morita I,Kaji K,Ikeda M,Nagao M,Murota S

更新日期：1993-09-15 00:00:00

abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

journal_title：Biochemical and biophysical research communications

authors： Styrt B,Schwartz MA,Klempner MS

更新日期：1988-08-15 00:00:00

abstract：:The most recently described region of alternate splicing of fibronectin mRNA results in expression of an isoform which includes the type III repeat termed ED B (EIII B). To date this isoform has been detected in transformed cells in culture, in the synovial membrane and ovary but in no other adult tissue, and in embry...

journal_title：Biochemical and biophysical research communications

authors： Burton-Wurster N,Lust G,Wert R

更新日期：1989-12-15 00:00:00

abstract：:Humoral hypercalcemia of malignancy (HHM) occurs when secretion of parathyroid hormone-related peptide (PTHrP) by cancer cells causes hypercalcemia in the absence of skeletal metastases. High extracellular calcium (Ca(2+)(o)) increases secretion of PTH-like bioactivity by rat H-500 leydig cells, a transplantable model...

journal_title：Biochemical and biophysical research communications

authors： Sanders JL,Chattopadhyay N,Kifor O,Yamaguchi T,Brown EM

更新日期：2000-03-16 00:00:00

abstract：:The sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein...

journal_title：Biochemical and biophysical research communications

authors： Rosini P,De Chiara G,Lucibello M,Garaci E,Cozzolino F,Torcia M

更新日期：2000-11-30 00:00:00

abstract：:Binding of [3H]-staurosporine to different protein kinases was time-dependent, reversible and saturable. Scatchard analysis of saturation isotherms indicated one class of binding sites for [3H]-staurosporine with dissociation constants (KD) of 9.6, 2.0, 3.0 and 7.4 nM for protein kinase C, cAMP-dependent protein kinas...

journal_title：Biochemical and biophysical research communications

authors： Herbert JM,Seban E,Maffrand JP

更新日期：1990-08-31 00:00:00

abstract：:We previously described the isolation of CDK4, representing the 3(')end of an unknown mRNA, using differential display [Biophys. Res. Commun. 232 (1997) 49]. To determine the identity of the CDK4 gene, full-length CDK4 cDNA clones were isolated from a diabetic kidney cDNA library. DNA sequencing revealed that CDK4 rep...

journal_title：Biochemical and biophysical research communications

authors： Page RA,Malik AN

更新日期：2003-10-17 00:00:00

abstract：:The programmed cell death plays a crucial role in the regulation of numerous physiological and pathological phenomena. In this study, we show that interleukin-1 beta (IL-1beta) induces an early production of endogenous ceramides via N-sphingomyelinase (N-Smase) as well as an inhibition of adenylyl cyclase activity in ...

journal_title：Biochemical and biophysical research communications

authors： El Btaouri H,Rath G,Morjani H,Schneider C,Petitfrere E,Antonicelli F,Martiny L

更新日期：2006-01-13 00:00:00

abstract：:The interaction of transketolase with its acceptor substrate, ribose 5-phosphate, has been studied. The active centers of the enzyme were shown to be functionally nonequivalent with respect to ribose 5-phosphate binding. Under the conditions where only one out of the two active centers of transketolase is functional, ...

journal_title：Biochemical and biophysical research communications

authors： Yurshev VA,Sevostyanova IA,Solovjeva ON,Zabrodskaya SV,Kochetov GA

更新日期：2007-10-05 00:00:00