Elevated levels of beta defensin-1 mRNA in diabetic kidneys of GK rats.

abstract：:Liver regeneration is controlled by multiple signaling pathways induced by a variety of growth factors, hormones, and cytokines. Here we report that protein kinase B (PKB)/Akt, part of a key cell survival signaling pathway, is markedly activated after partial hepatectomy (PHX). The antiapoptotic protein Bad, a downstr...

journal_title：Biochemical and biophysical research communications

authors： Hong F,Nguyen VA,Shen X,Kunos G,Gao B

更新日期：2000-12-29 00:00:00

abstract：:Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3.1.5) were expressed in monkey kidney COS-1 cells and used to study the N- and O-acetylation of a number of carcinogenic amines and their N-hydroxy metabolites. The monomorphic enzyme N-acetylated the aromatic amines, 2-aminofluorene and 4-aminobiph...

journal_title：Biochemical and biophysical research communications

authors： Minchin RF,Reeves PT,Teitel CH,McManus ME,Mojarrabi B,Ilett KF,Kadlubar FF

更新日期：1992-06-30 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00

abstract：:The molecular mechanism of smooth muscle contraction was approached by a novel method, covalent 14C-labeling. Intra- and intermolecular protein interactions during contractile activity are reflected by changed reactivity of protein side chains; these can be detected by reagents which readily permeate through the muscl...

journal_title：Biochemical and biophysical research communications

authors： Bárány K,Polyák E,Bárány M

更新日期：1992-09-16 00:00:00

abstract：:We investigated the endogenous mono(ADP-ribosyl)ation of the sarcoplasmic reticulum from rabbit skeletal muscle. The autoradiogram obtained after sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the [adenylate-32P]NAD-treated sarcoplasmic reticulum vesicles revealed a major band corresponding to the MW 105...

journal_title：Biochemical and biophysical research communications

authors： Hara N,Mishima K,Tsuchiya M,Tanigawa Y,Shimoyama M

更新日期：1987-04-29 00:00:00

abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

更新日期：2000-07-05 00:00:00

abstract：:The sphingolipids, sphingosine (SPH), sphingosylphosphorylcholine (SPC) and psycosine induce a rapid and transient rise in nuclear free Ca2+ concentration in a dose dependent manner. To determine whether these sphingolipids act by a IP3-dependent pathway, we tested the increase of Ca2+ in the presence of heparin, an a...

journal_title：Biochemical and biophysical research communications

authors： Catalán RE,Miguel BG,Calcerrada MC,Ruiz S,Martínez AM

更新日期：1997-09-18 00:00:00

abstract：:The muscarinic acetylcholine receptor was solubilized, in a sensitive form for GTP and Na+, from bovine cerebral cortex using a zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate. The solubilized muscarinic receptor displayed characteristics as follows: (1) high affinity to nanomolar co...

journal_title：Biochemical and biophysical research communications

authors： Kuno T,Shirakawa O,Tanaka C

更新日期：1983-05-16 00:00:00

abstract：:Some mutations in mitochondrial DNA (mtDNA) causing a number of neuromuscular diseases are suggested to arise spontaneously during the life of an individual. To substantiate the extent and the rate of these somatic mutations, mtDNA specimens from post-mortem human heart muscles of subjects in differing age groups were...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hattori K,Sugiyama S,Ozawa T

更新日期：1992-12-15 00:00:00

abstract：:Rap1 and Rap2 are similar Ras-like G proteins but perform distinct functions. By the affinity chromatography/mass-spectrometry approach and the yeast two-hybrid screening, we identified Misshapen/NIKs-related kinase (MINK) as a novel Rap2-interacting protein that does not interact with Rap1 or Ras. MINK is a member of...

journal_title：Biochemical and biophysical research communications

authors： Nonaka H,Takei K,Umikawa M,Oshiro M,Kuninaka K,Bayarjargal M,Asato T,Yamashiro Y,Uechi Y,Endo S,Suzuki T,Kariya KI

更新日期：2008-12-12 00:00:00

abstract：:We have recently identified in porcine brain a series of new peptides, designated calcitonin receptor-stimulating peptide-1 (CRSP-1), CRSP-2, and CRSP-3, but failed to find their counterparts in humans and rodents by either database searching or experimental cross-hybridization. In this study, we isolated cDNAs encodi...

journal_title：Biochemical and biophysical research communications

authors： Katafuchi T,Hamano K,Minamino N

更新日期：2004-01-02 00:00:00

abstract：:The human pregnane X receptor (hPXR) plays a key role in the regulation of both drug metabolism and efflux by inducing the expression of CYP3A4 and MDR1 gene. Using reverse transcription-polymerase chain reaction (RT-PCR) analysis, we identified seven novel splicing variants of hPXR in tissue from a single human liver...

journal_title：Biochemical and biophysical research communications

authors： Fukuen S,Fukuda T,Matsuda H,Sumida A,Yamamoto I,Inaba T,Azuma J

更新日期：2002-11-01 00:00:00

abstract：:7,8-Dihydrobiopterin is not an intermediate in the de novo biosynthesis of tetrahydrobiopterin, the cofactor required for aromatic amino acid hydroxylations. However, N-acetyl-serotonin inhibition of sepiapterin reductase, an enzyme whose previously only known function was the reduction of sepiapterin to 7,8-dihydrobi...

journal_title：Biochemical and biophysical research communications

authors： Milstien S,Kaufman S

更新日期：1983-09-30 00:00:00

abstract：:Kinase suppressor of ras (KSR) and MEKK3 (MAP kinase kinase kinase) are integral members of the MAP kinase pathway. We have recently identified a new isoform of the KSR family named human kinase suppressor of ras-2 (hKSR-2), and demonstrated that hKSR-2 negatively regulates Cot, a MAP3K family member which is importan...

journal_title：Biochemical and biophysical research communications

authors： Channavajhala PL,Rao VR,Spaulding V,Lin LL,Zhang YG

更新日期：2005-09-09 00:00:00

abstract：:To study cellular and subcellular localization of TIMP-1, we constructed a cDNA which would express a chimeric protein, TIMP-1-EGFP, having the enhanced green fluorescent protein of the jelly fish Aequorea victoria fused to the carboxyl-terminus of TIMP-1. Chinese Hamster Ovary (CHO) cells were stably transfected with...

journal_title：Biochemical and biophysical research communications

authors： Ritter LM,Garfield SH,Thorgeirsson UP

更新日期：1999-04-13 00:00:00

abstract：:ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. AB...

journal_title：Biochemical and biophysical research communications

authors： Ozvegy C,Litman T,Szakács G,Nagy Z,Bates S,Váradi A,Sarkadi B

更新日期：2001-07-06 00:00:00

abstract：:Incorporation of 1-[3H]-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ([3H] PAF-acether) into rabbit platelet phosphatidylcholine (PC) was inhibited by a specific antagonist, BN 52021 (IC50 5.6 X 10(-6) M, maximal effect, i.e 70% inhibition, at 10(-4) M). Under the same conditions, [3H] lyso-PAF-acether incorporation r...

journal_title：Biochemical and biophysical research communications

authors： Lachachi H,Plantavid M,Simon MF,Chap H,Braquet P,Douste-Blazy L

更新日期：1985-10-30 00:00:00

abstract：:The abilities of FK506 and rapamycin to block distinct signal transduction pathways are mediated by soluble binding proteins. Previously, a family of these receptors has been recognized that includes a 25 kDa protein, FKBP25. We now report the isolation of a cDNA for FKBP25 from a human hippocampal cDNA library by oli...

journal_title：Biochemical and biophysical research communications

authors： Hung DT,Schreiber SL

更新日期：1992-04-30 00:00:00

abstract：:The Mechanosensitive channel of Large conductance (MscL) allows bacteria to rapidly adapt to changing environmental conditions such as osmolarity. The MscL channel opens in response to increases in membrane tension, which allows for the efflux of cytoplasmic constituents. Here we describe the cloning and expression of...

journal_title：Biochemical and biophysical research communications

authors： Jones SE,Naik RR,Stone MO

更新日期：2000-12-09 00:00:00

abstract：:Receptor-mediated regulation of guanylate cyclase is well-studied in intact Dictyostelium discoideum cells, but study of the enzyme in cell-free preparations has hampered. A major obstacle has been that in vitro guanylate cyclase activity could be detected only in the presence of unphysiological concentrations of Mn2+...

journal_title：Biochemical and biophysical research communications

authors： Janssens PM,de Jong CC

更新日期：1988-01-15 00:00:00

abstract：:bis-cyclopentadienyl [Cp] complexes of vanadium(IV) or vanadocenes are rapid and potent inhibitors of human sperm motility with potential as a new class of contraceptive agents. We investigated the utility of boar sperm as a model system to study the mechanisms of drug action because boar sperm lacks phosphocreatine a...

journal_title：Biochemical and biophysical research communications

authors： D'Cruz OJ,Vassilev A,Uckun FM

更新日期：2000-04-21 00:00:00

abstract：:Autophagy is the bulk degradation of cytosolic materials in lysosomes/vacuoles of eukaryotic cells. In the yeast Saccharomyces cerevisiae, 17 Atg proteins are known to be involved in autophagosome formation. Genome wide analyses have shown that Atg17 interacts with numerous proteins. Further studies on these interacti...

journal_title：Biochemical and biophysical research communications

authors： Kabeya Y,Kawamata T,Suzuki K,Ohsumi Y

更新日期：2007-05-04 00:00:00

abstract：:Adipogenesis is the process of differentiation from preadipocytes to adipocytes and is orchestrated by various transcription factors, such as the peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAAT-enhancer-binding protein alpha (C/EBPα). Oxidative stress is also a crucial factor in adipogenesis, an...

journal_title：Biochemical and biophysical research communications

authors： Kim BR,Lee GY,Yu H,Maeng HJ,Oh TJ,Kim KM,Moon JH,Lim S,Jang HC,Choi SH

更新日期：2018-03-18 00:00:00

abstract：:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30....

journal_title：Biochemical and biophysical research communications

authors： Yamaga N,Adachi K,Kohara H,Shimizu K

更新日期：1988-04-15 00:00:00

abstract：:AHNAK is a giant protein of approximately 700 kDa identified in human neuroblastomas and skin epithelial cells. Recently, we found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analys...

journal_title：Biochemical and biophysical research communications

authors： Kim IY,Jung J,Jang M,Ahn YG,Shin JH,Choi JW,Sohn MR,Shin SM,Kang DG,Lee HS,Bae YS,Ryu DH,Seong JK,Hwang GS

更新日期：2010-12-17 00:00:00

abstract：:Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis method...

journal_title：Biochemical and biophysical research communications

authors： Guda P,Bourne PE,Guda C

更新日期：2007-01-12 00:00:00

abstract：:The peroxisome proliferator activated receptors (PPARs) alpha, beta/delta, and gamma are novel nuclear hormone receptors activated by long chain fatty acids and synthetic ligands and which regulate lipid metabolism. Recent studies have detected PPARgamma mRNA in human mammary tumor cell lines. The current study examin...

journal_title：Biochemical and biophysical research communications

authors： Gimble JM,Pighetti GM,Lerner MR,Wu X,Lightfoot SA,Brackett DJ,Darcy K,Hollingsworth AB

更新日期：1998-12-30 00:00:00

abstract：:Under nitrosative stressed condition intracellular GSNO accumulation is common to all cell types. Conserved NADH-dependent GSNO reductase was reported previously as an important cellular protective measure against this. In spite of the constitutive nature of the enzyme, we observed in vivo inactivation of two importan...

journal_title：Biochemical and biophysical research communications

authors： Sahoo R,Sengupta R,Ghosh S

更新日期：2003-03-21 00:00:00

abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

journal_title：Biochemical and biophysical research communications

authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

更新日期：2017-08-26 00:00:00

abstract：:The cooperation of phosphofructokinase-2 and fructose-2,6-bisphosphatase is investigated. Experimentally derived rate laws of the kinase and bisphosphatase activities introduced into the respective differential equations permitted to describe the time evolution of fructose-2,6-bisphosphate to quasi-stationary levels. ...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Schellenberger W,Hofmann E

更新日期：1985-09-16 00:00:00