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Sphingolipids increase calcium concentration in isolated rat liver nuclei.

Abstract：

:The sphingolipids, sphingosine (SPH), sphingosylphosphorylcholine (SPC) and psycosine induce a rapid and transient rise in nuclear free Ca2+ concentration in a dose dependent manner. To determine whether these sphingolipids act by a IP3-dependent pathway, we tested the increase of Ca2+ in the presence of heparin, an antagonist of IP3 receptor or U70122, an inhibitor of phospholipase C. Results indicate that the effect of both SPH and SPC, but not that of psychosine, is partially mediated by IP3 production. The sphingolipid-induced Ca2+ mobilization was unaffected by the inhibition of protein kinase C, but was totally abolished in the presence of nimodipine, a L-type Ca2+ channel inhibitor. The results could indicate the existence of a sphingosine-gated Ca2+-permeable channel in liver nuclei.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Catalán RE,Miguel BG,Calcerrada MC,Ruiz S,Martínez AM

doi

10.1006/bbrc.1997.7302

subject

Has Abstract

pub_date

1997-09-18 00:00:00

pages

347-50

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X97973022

journal_volume

238

pub_type

杂志文章

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