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1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.

Abstract：

:The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells and induces differentiation to cells resembling mononuclear phagocytes. HL-60 cultures incubated for 6 days with 1-0-hexadecyl-2-acetyl-sn-glycerol (5 micrograms/ml) demonstrated a ten-fold increase in nonspecific esterase activity, and produced cells with morphological features similar to those of monocytes and macrophages. Higher concentrations of 1-0-hexadecyl-2-acetyl-sn-glycerol significantly inhibited the growth of HL-60 cells and resulted in the virtual absence of cells resembling the original HL-60 line. 1-0-Oleoyl-2-acetyl-rac-glycerol added under the same conditions did not induce cell differentiation or inhibit cell growth.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

McNamara MJ,Schmitt JD,Wykle RL,Daniel LW

doi

10.1016/s0006-291x(84)80108-4

subject

Has Abstract

pub_date

1984-07-31 00:00:00

pages

824-30

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80108-4

journal_volume

122

pub_type

杂志文章

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