当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > The effect of long-term treatment with erythromycin on Th1 and Th2 cytokines in diffuse panbronchiolitis.

The effect of long-term treatment with erythromycin on Th1 and Th2 cytokines in diffuse panbronchiolitis.

Abstract：

:Diffuse panbronchiolitis (DPB) is a chronic progressive disease of the respiratory bronchioles, and has been improved by low-dose, long-term erythromycin (EMC) treatment. The therapeutic benefits may be derived from its anti-inflammatory and immunomodulatory properties rather than antimicrobial effect. However, there are few studies about the mechanism of immunomodulation by EMC treatment for patient with DPB. In this study, we quantified the changes of Th1 and Th2 cytokines in the bronchoalveolar lavage (BAL) fluid from patients with DPB after long term treatment with EMC. After the EMC treatment, a significant reduction in the number of lymphocytes was observed, and the CD4/CD8 ratio was elevated as well. The IL-2 and IFN-gamma levels in the BAL fluid were significantly decreased and the IL-4, IL-5, and IL-13 levels were significantly increased after EMC treatment. Our results suggest that the therapeutic benefits of long-term EMC treatment may be partially due to the immune system's shift from Th1 to Th2 cytokine production.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Park SJ,Lee YC,Rhee YK,Lee HB

doi

10.1016/j.bbrc.2004.09.018

subject

Has Abstract

pub_date

2004-11-05 00:00:00

pages

114-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02055-8

journal_volume

324

pub_type

杂志文章

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