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A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA.

Abstract：

:We demonstrate that the product of the yeast open reading frame YML005w is required for wybutosine (yW) formation in the phenylalanine-accepting tRNA of the yeast Saccharomyces cerevisiae. tRNA isolated from a deletion mutant of the YML005w gene accumulates 4-demethylwyosine (ImG-14), a precursor lacking three of the methyl groups of the yW hypermodified base. Since the amino acid sequence of the YML005w gene contains the signature motifs of the seven beta-strand methyltransferases, we now designate the gene TRM12 for tRNA methyltransferase. Using pulse-chase labeling of intact yeast cells with S-adenosyl-L-[methyl-(3)H]methionine, we show that the methylesterified form of yW is metabolically stable.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kalhor HR,Penjwini M,Clarke S

doi

10.1016/j.bbrc.2005.06.111

subject

Has Abstract

pub_date

2005-08-26 00:00:00

pages

433-40

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)01337-9

journal_volume

334

pub_type

杂志文章

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