Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells.

abstract：:The immunoglobulin G of a polyclonal antiserum (pIgG) from a patient with insulin resistance and hypoglycemia was tested for its ability to inhibit insulin binding and to affect the autophosphorylation of partially-purified insulin receptors extracted from rat liver membranes. pIgG, when added 4 hr prior to insulin, i...

journal_title：Biochemical and biophysical research communications

authors： Cordera R,Gherzi R,De Pirro R,Rossetti L,Freidenberg GR,Andraghetti G,Lauro R,Adezati L

更新日期：1985-11-15 00:00:00

abstract：:Pancreatic islets of Langerhans were perifused with Krebs-bicarbonate solution containing glucose (5 and 10 mM). The perifusate was spiked with tetradeuterated hepoxilin A3 and was extracted and analysed by gas chromatography-mass spectrometry using NICI detection. Evidence is presented showing the presence of hepoxil...

journal_title：Biochemical and biophysical research communications

authors： Pace-Asciak CR,Martin JM,Corey EJ,Su WG

更新日期：1985-04-30 00:00:00

abstract：:Angiogenesis is a fundamental process by which new blood vessels are formed. The angiogenesis process is induced by several growth factors. Among them angiogenin is the most potent blood vessel inducer known. In this paper, we have investigated the effect of green tea polyphenols, mainly the catechins, on an angiogeni...

journal_title：Biochemical and biophysical research communications

authors： Maiti TK,Chatterjee J,Dasgupta S

更新日期：2003-08-15 00:00:00

abstract：:By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate ...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Silva MJ,Sato K,Ouhara K,Kawai T

更新日期：2009-08-14 00:00:00

abstract：:Intercellular spaces between adjacent mucosal epithelial cells are sealed by tight junctions (TJs) that prevent the free movement of solutes across the epithelium. Claudins (CLs), a family of 27 integral membrane proteins, are essential components for TJ seals. We previously used a CL-3/-4 binder, the C-terminal fragm...

journal_title：Biochemical and biophysical research communications

authors： Matsuhisa K,Kondoh M,Suzuki H,Yagi K

更新日期：2012-06-29 00:00:00

abstract：:Incubation of lipoxin A4 (LXA4) either with human leukocytes or with rat liver microsomes in the presence of NADPH very selectively led to a more polar metabolite retaining the conjugated tetraenic structure of LXA4. Lipoxin B4 (LXB4) underwent a very similar metabolism into a more polar metabolite, whereas the all-tr...

journal_title：Biochemical and biophysical research communications

authors： Boucher JL,Delaforge M,Mansuy D

更新日期：1991-05-31 00:00:00

abstract：AIMS:Insulin-like growth factor-1 (IGF-1) is a polypeptide protein hormone, similar in molecular structure to insulin, which plays an important role in cell migration, cell cycle progression, cell survival and proliferation. In this study, we investigated the possible mechanisms of IGF-1 mediated cell cycle redistribut...

journal_title：Biochemical and biophysical research communications

authors： Ma QL,Yang TL,Yin JY,Peng ZY,Yu M,Liu ZQ,Chen FP

更新日期：2009-11-06 00:00:00

abstract：:Human prostasin was recently identified as a potential regulator of epithelial sodium channel (ENaC) function. Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 prefer...

journal_title：Biochemical and biophysical research communications

authors： Shipway A,Danahay H,Williams JA,Tully DC,Backes BJ,Harris JL

更新日期：2004-11-12 00:00:00

abstract：:Carbon monoxide (CO) and nitric oxide (NO) are two gas molecules which have cytoprotective functions against oxidative stress and inflammatory responses in many cell types. Currently, it is known that NO produced by nitric oxide synthase (NOS) induces heme oxygenase 1 (HO1) expression and CO produced by the HO1 inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lee BS,Heo J,Kim YM,Shim SM,Pae HO,Kim YM,Chung HT

更新日期：2006-05-12 00:00:00

abstract：:Resolvin E1 (RvE1; 5S, 12R, 18R-trihydroxyeicosapentaenoic acid) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid eicosapentaenoic acid (EPA). It has been recently shown that RvE1 is involved in the resolution of inflammation. However, it is not known whether RvE1 is involved in the resolutio...

journal_title：Biochemical and biophysical research communications

authors： Aoki H,Hisada T,Ishizuka T,Utsugi M,Kawata T,Shimizu Y,Okajima F,Dobashi K,Mori M

更新日期：2008-03-07 00:00:00

abstract：:Production of endothelin-1 in the cultured neonatal rat cardiac myocytes was investigated. Studies on the cultured cardiac myocytes with reverse transcription-polymerase chain reaction followed by Southern hybridization indicated that mRNA of ET-1(preproET-1 mRNA) was expressed by cardiac myocytes. ET-1 polypeptide wa...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kumazaki T,Mitsui Y

更新日期：1993-03-31 00:00:00

abstract：:Mutation of the Patched gene has been detected in human inherited basal cell nevus syndrome (BCNS) and sporadic basal cell carcinomas (BCC), suggesting a strong relation between a Sonic hedgehog-Patched signal and cell proliferation. In the present study, we demonstrate that Sonic hedgehog is expressed in human lung s...

journal_title：Biochemical and biophysical research communications

authors： Fujita E,Khoroku Y,Urase K,Tsukahara T,Momoi MY,Kumagai H,Takemura T,Kuroki T,Momoi T

更新日期：1997-09-18 00:00:00

abstract：:The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes. Microfold cell inducer (MCi) cells in GALTs are the recently identified mesenchymal cel...

journal_title：Biochemical and biophysical research communications

authors： Nagashima K,Sawa S,Nitta T,Prados A,Koliaraki V,Kollias G,Nakashima T,Takayanagi H

更新日期：2017-11-04 00:00:00

abstract：:α-Isopropylmalate synthase (α-IPMS) is a multi-domain protein catalysing the condensation of α-ketoisovalerate (α-KIV) and acetyl coenzyme A (AcCoA) to form α-isopropylmalate. This reaction is the first committed step in the leucine biosynthetic pathway in bacteria and plants, and α-IPMS is allosterically regulated by...

journal_title：Biochemical and biophysical research communications

authors： Huisman FH,Squire CJ,Parker EJ

更新日期：2013-04-05 00:00:00

abstract：:Glucocorticoid receptors (GRs) are extensively studied members of the steroid hormone receptor superfamily that regulate the transcription rates of numerous genes. Notwithstanding, the role of each GR amino acid in the various steps of transactivation is still unknown. A recent report shows that linear DNA has the sam...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Blackford JA Jr,Simons SS Jr

更新日期：2004-09-03 00:00:00

abstract：:Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

journal_title：Biochemical and biophysical research communications

authors： Monleón D,Esteve V,Celda B

更新日期：2003-03-28 00:00:00

abstract：:The 160 kDa alpha-mannosidase (E.C. 3.2.1.24) isolated from culture filtrate of Trichoderma reesei has wide aglycon specificity but cleaves the alpha1 --> 2 and alpha1 --> 3 mannosidic bonds with higher rate than alpha1 --> 6 bond and slowly hydrolyses yeast mannan and 1,6-alpha-mannan. The specific activity of the en...

journal_title：Biochemical and biophysical research communications

authors： Eneyskaya EV,Kulminskaya AA,Savel'ev AN,Shabalin KA,Golubev AM,Neustroev KN

更新日期：1998-04-07 00:00:00

abstract：:Opioid binding properties of Tyr-D-Ser-Gly-Phe-Leu-Thr-NH-NH-Gly-Mal (DSLET-Mal), a novel enkephalin-framed affinity label, was determined in rat brain membranes. In competition studies the ligand showed high affinity for the delta opioid sites, labelled by [(3)H][Ile(5,6)]deltorphin II (K(i) = 8 nM), whereas its bind...

journal_title：Biochemical and biophysical research communications

authors： Szatmári I,Orosz G,Medzihradszky K,Borsodi A

更新日期：1999-11-19 00:00:00

abstract：:We hypothesized that the mutational strand asymmetry is more strongly exerted upon the mitochondrial cytochrome b (Cytb) gene, which is distant from the origin of the light-strand replication (Ori(L)), than upon the ATPase subunit 6 (ATP6) gene, which is close to the Ori(L). To test this hypothesis, we determined the ...

journal_title：Biochemical and biophysical research communications

authors： Fuku N,Oshida Y,Takeyasu T,Guo LJ,Kurata M,Yamada Y,Sato Y,Tanaka M

更新日期：2002-02-01 00:00:00

abstract：:The ability to simultaneously isolate intact DNA-free RNA, genomic DNA, and proteins from a biological specimen can be useful in cloning genes and analyzing gene expression. Equilibrium density gradient centrifugation with CsCl is a useful tool for fractionating, quantitatively separating, and characterizing RNA, DNA,...

journal_title：Biochemical and biophysical research communications

authors： Zhang H,Chen HT,Glisin V

更新日期：2003-12-05 00:00:00

abstract：:In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12-months-old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA, or c9t11-CLA+t10c12-CLA (CLA-mix) for 6months. Both t10c12-CLA and CLA-...

journal_title：Biochemical and biophysical research communications

authors： Rahman M,Halade GV,El Jamali A,Fernandes G

更新日期：2009-06-12 00:00:00

abstract：:Emerging evidence has indicated that transforming growth factor-beta 1 (TGF-β1) induces the epithelial-mesenchymal transition (EMT) in cancer cells, thus promoting their motility and invasiveness. Quercetin, a member of the polyphenolic flavonoid family, has been reported to display anticancer activity against a broad...

journal_title：Biochemical and biophysical research communications

authors： Feng J,Song D,Jiang S,Yang X,Ding T,Zhang H,Luo J,Liao J,Yin Q

更新日期：2018-03-25 00:00:00

abstract：:Opioid agonists either potentiate or suppress basal cAMP production in SK-N-SH cells. The inhibitory effect is mediated by PTX-sensitive GTP-binding proteins, while the stimulatory effect involves Ca++ entry and calmodulin activation. Both pathways can be activated simultaneously by opioid agonists. Low (nM) concentra...

journal_title：Biochemical and biophysical research communications

authors： Sarne Y,Rubovitch V,Fields A,Gafni M

更新日期：1998-05-08 00:00:00

abstract：:The tyrosine kinase Fms, the cell surface receptor for M-CSF and IL-34, is critical for microglial proliferation and differentiation in the brain. Recently, a number of mutations have been identified in Fms as a putative genetic cause of hereditary diffuse leukoencephalopathy with spheroids (HDLS), implying an importa...

journal_title：Biochemical and biophysical research communications

authors： Hiyoshi M,Hashimoto M,Yukihara M,Bhuyan F,Suzu S

更新日期：2013-11-01 00:00:00

abstract：:This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

journal_title：Biochemical and biophysical research communications

authors： Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

更新日期：2015-08-28 00:00:00

abstract：:A suitable antibody for immunoaffinity chromatography is considered to efficiently bind the antigen in the adsorption step and to dissociate the bound antigen with mild changes in the environmental conditions. To develop an effective method for preparing such antibodies, murine antisera elicited by the primary and sec...

journal_title：Biochemical and biophysical research communications

authors： Enomoto A,Kamata N,Nakamura K

更新日期：1994-06-15 00:00:00

abstract：:Activation of protein kinase C has been shown to be involved in the activation pathway of many cell types. Recently, a number of investigations have suggested that protein kinase C plays an essential role in T lymphocyte activation. The recent synthesis of the protein kinase inhibitors, H-7 and HA1004, have now made p...

journal_title：Biochemical and biophysical research communications

authors： Clark RB,Love JT Jr,Sgroi D,Lingenheld EG,Sha'afi RI

更新日期：1987-06-15 00:00:00

abstract：:Acyl coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the intracellular synthesis of cholesteryl esters (CE). Both ACAT isoforms, ACAT1 and ACAT2, play key roles in the pathophysiology of atherosclerosis and ACAT inhibition retards atherosclerosis in animal models. Rimonabant, a type 1 cannabinoid receptor (CB1...

journal_title：Biochemical and biophysical research communications

authors： Netherland C,Thewke DP

更新日期：2010-08-06 00:00:00

abstract：:The patch clamp technique applied to canine atrial myocyte sarcolemma, showed that 2 types of K+ channels were differentially affected by Ach. The 2 channel types differed in conductance, responses to [Ca++], and sensitivity to membrane potential. Addition of Ach (10(-9) M to 10(-6) M) to pipette solutions increased o...

journal_title：Biochemical and biophysical research communications

authors： Bubien JK,Woods WT Jr

更新日期：1987-02-13 00:00:00

abstract：:Four IgE-binding epitopes have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum). They mainly correspond to electropositively charged regions protruding on the molecular surface of the modeled apple (Mal d 3), apr...

journal_title：Biochemical and biophysical research communications

authors： Borges JP,Barre A,Culerrier R,Granier C,Didier A,Rougé P

更新日期：2008-01-25 00:00:00