The role of wogonin in controlling SOCS3 expression in neuronal cells.

abstract：:Ornithine decarboxylase (ODC), which catalyzes polyamine biosynthesis, plays an essential role in cell growth. DL-alpha-Difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, inhibits cell growth. However, the exact mechanism by which polyamine depletion by DFMO results in growth inhibition remains to be elucid...

journal_title：Biochemical and biophysical research communications

authors： Nemoto T,Kamei S,Seyama Y,Kubota S

更新日期：2001-01-26 00:00:00

abstract：:Dlx5 transcription factor plays important roles in osteoblast differentiation and its transcription is regulated by many osteogenic signals including BMP-2. Recent studies suggest that the function of Dlx5 is also regulated post-translationally by protein kinases such as p38 and CaMKII. Protein kinase A (PKA) is invol...

journal_title：Biochemical and biophysical research communications

authors： Han Y,Jin YH,Yum J,Jeong HM,Choi JK,Yeo CY,Lee KY

更新日期：2011-04-15 00:00:00

abstract：:Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. In this study, we revealed that peiminine induces ce...

journal_title：Biochemical and biophysical research communications

authors： Lyu Q,Tou F,Su H,Wu X,Chen X,Zheng Z

更新日期：2015-06-19 00:00:00

abstract：:Deformation of vacuolar membranes mediated by endosomal sorting complex required for transport (ESCRT) is necessary for microautophagy. Target of rapamycin complex 1 (TORC1) protein kinase negatively regulates ESCRT-0 (Vps27-Hse1) recruitment onto vacuolar membranes and microautophagy induction. However, whether and h...

journal_title：Biochemical and biophysical research communications

authors： Sharmin T,Morshed S,Ushimaru T

更新日期：2020-04-09 00:00:00

abstract：:Increasing the number of transcription factor binding sites within a construct can enhance expression. In an attempt to create a synthetic locus control region for mammary expression, we have generated beta-lactoglobulin-reporter constructs with multiple copies of the cluster of transcription sites normally located wi...

journal_title：Biochemical and biophysical research communications

authors： James RM,Neil C,Webster J,Roos S,Clark AJ,Whitelaw CB

更新日期：2000-05-27 00:00:00

abstract：:Hydrophobic modifications of transducin (T) gamma, such as farnesyl-and carboxyl-methylation, are essential for the association of T beta gamma with the photoreceptor disc membrane, and MEKA/phosducin is known to inhibit the association. In this study, we examined the effect of MEKA on the hydrophobicity of T beta gam...

journal_title：Biochemical and biophysical research communications

authors： Tanaka H,Kuo CH,Matsuda T,Fukada Y,Hayashi F,Ding Y,Irie Y,Miki N

更新日期：1996-06-25 00:00:00

abstract：:We found that high galectin-1 (Gal-1) mRNA levels were associated with invasive squamous cell carcinoma (SCC) cells that expressed Snail, an epithelial-to-mesenchymal transition (EMT) regulator. Both Gal-1 overexpression and soluble Gal-1 treatment accelerated invasion and collective cell migration, along with activat...

journal_title：Biochemical and biophysical research communications

authors： Rizqiawan A,Tobiume K,Okui G,Yamamoto K,Shigeishi H,Ono S,Shimasue H,Takechi M,Higashikawa K,Kamata N

更新日期：2013-11-29 00:00:00

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:Tetraheme cytochrome c3 (13 kDa) and flavodoxin (16 kDa), are small electron transfer proteins that have been used to mimic, in vitro, part of the electron-transfer chain that operates between substract electron donors and respiratory electron acceptors partners in Desulfovibrio species (Palma, N., Moura, I., LeGall, ...

journal_title：Biochemical and biophysical research communications

authors： Correia C,Monzani E,Moura I,Lampreia J,Moura JJ

更新日期：1999-03-16 00:00:00

abstract：:Vascular pericytes and smooth muscle cells surround many blood vessels of the body. Their primary roles include vessel stabilization and regulation of the blood flow. The high degree of heterogeneity among these cells is dictated by (1) differences in their developmental origin and (2) their location in the vascular b...

journal_title：Biochemical and biophysical research communications

authors： Halaidych OV,Mummery CL,Orlova VV

更新日期：2019-05-21 00:00:00

abstract：:Development of Grb2-SH2 domain antagonists is considered to be an effective and non-cytotoxic strategy to develop new antiproliferative agents because of their potential to shut down the Ras signaling pathway. We developed a concise route for the efficient synthesis of G1TE analogs on solid phase. Using this route, a ...

journal_title：Biochemical and biophysical research communications

authors： Jiang S,Li P,Peach ML,Bindu L,Worthy KW,Fisher RJ,Burke TR Jr,Nicklaus M,Roller PP

更新日期：2006-10-20 00:00:00

abstract：:Monoclonal antibodies are valuable laboratory reagents and are increasingly being exploited as therapeutics to treat a range of diseases. Selecting new monoclonal antibodies that are validated to work in particular applications, despite the availability of several different techniques, can be resource intensive with u...

journal_title：Biochemical and biophysical research communications

authors： Staudt N,Müller-Sienerth N,Wright GJ

更新日期：2014-03-21 00:00:00

abstract：:Monodisperse bovine prothrombin was prepared and its molecular states under several conditions examined. The protein showed no tendency to self-associate in the absence of calcium. Calcium (4 mM) caused small increases in the apparent molecular weight of the protein which may or may not represent protein dimerization ...

journal_title：Biochemical and biophysical research communications

authors： Silversmith RE,Wei GJ,Nelsestuen GL

更新日期：1983-02-28 00:00:00

abstract：:Stem cells have been identified using the DNA-binding dye Hoechst 33342 and flow cytometry (FCM) in various tissues known as the side population (SP). The present study shows, for the first time, the presence of side population cells in human deciduous dental pulp cells (DPCs). Flow cytometric identification revealed ...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Wei X,Ling J,Huang Y,Huo Y,Zhou Y

更新日期：2010-09-24 00:00:00

abstract：:To study cellular and subcellular localization of TIMP-1, we constructed a cDNA which would express a chimeric protein, TIMP-1-EGFP, having the enhanced green fluorescent protein of the jelly fish Aequorea victoria fused to the carboxyl-terminus of TIMP-1. Chinese Hamster Ovary (CHO) cells were stably transfected with...

journal_title：Biochemical and biophysical research communications

authors： Ritter LM,Garfield SH,Thorgeirsson UP

更新日期：1999-04-13 00:00:00

abstract：:Hydrogenovibrio marinus strain MH-110, an obligately lithoautotrophic hydrogen-oxidizing bacterium, possesses three sets of the genes for ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO): namely, two form I type (cbbLS-1 and cbbLS-2) and one form II type (cbbM) enzymes. The cbbQ-m gene was located downstream ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi NR,Arai H,Kodama T,Igarashi Y

更新日期：1999-11-01 00:00:00

abstract：:Recent years have seen considerable evolution in our understanding of the mechanisms of oxygen activation by non-heme iron enzymes, with high-valent iron-oxo intermediates coming to the forefront as formidably potent oxidants. In the absence of substrate, the generation of vividly colored chromophores deriving from th...

journal_title：Biochemical and biophysical research communications

authors： Farquhar ER,Koehntop KD,Emerson JP,Que L Jr

更新日期：2005-12-09 00:00:00

abstract：:3-Deoxyglucosone (3-DG) is a metabolite of glucose that is thought to lead to the production of advanced glycation end products in diabetes. The previous assay for 3-DG in serum was based on a multi-step protocol, including derivatization, extraction, HPLC separation, and detection. In the current studies, we establis...

journal_title：Biochemical and biophysical research communications

authors： Uchida Y,Kurano Y,Endo T,Aoyama M,Ito S

更新日期：2004-12-17 00:00:00

abstract：:Arginine kinase catalyzes the reversible transfer of a phosphoryl group between ATP and l-arginine and is a monomeric homolog of the human enzyme creatine kinase. Arginine and creatine kinases belongs to the phosphagen kinase family of enzymes, which consists of eight known members, each of which is specific for its o...

journal_title：Biochemical and biophysical research communications

authors： Clark SA,Davulcu O,Chapman MS

更新日期：2012-10-12 00:00:00

abstract：:Mouse MARCKS is a prominent myristoylated alanine-rich C kinase substrate implicated in brain development, calcium/calmodulin signaling, and membrane cytoskeletal restructuring, and is developmentally regulated in a cell- and tissue-specific fashion. In this study, transcriptional regulation of mouse MARCKS promoter i...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Liu X,Lenox RH

更新日期：2002-04-12 00:00:00

abstract：:To identify the target autoantigens in Vogt-Koyanagi-Harada disease, we made use of an immunoscreening of a bovine uveal cDNA expression library with serum samples obtained from patients with Vogt-Koyanagi-Harada disease. We identified a novel bovine antigen and homologous human autoantigen and designated it as UACA (...

journal_title：Biochemical and biophysical research communications

authors： Yamada K,Senju S,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

更新日期：2001-02-02 00:00:00

abstract：:DJ-1 is a multi-functional protein that plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in onset of Parkinson's disease. We have previously reported that L166P, a mutant DJ-1 found in Parkinson's disease patients, had no activity to prevent hydrogen pe...

journal_title：Biochemical and biophysical research communications

authors： Takahashi-Niki K,Niki T,Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-07-23 00:00:00

abstract：BACKGROUND:Research has indicated that Herba Patriniae can suppress the growth of Several kinds of tumor cells in vitro and in vivo, thus displaying favorable antitumor activity. However, research regarding the effect of saponins of Patrinia villosa against CRC cell has not been reported. In the current study, We have ...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Zhang B,Yan Q,Ruan S

更新日期：2018-09-10 00:00:00

abstract：:The secretory response of purified beta cells was studied employing a newly developed microperifusion technique. In control experiments, initial high insulin release up to 50 minutes followed by a steady state basal level was observed up to five hours. The changes in hydrodynamic pressure of perifusion produced small,...

journal_title：Biochemical and biophysical research communications

authors： Bandisode MS

更新日期：1988-03-15 00:00:00

abstract：:Streptococcus mutans, a member of the viridans streptococci, is the etiologic agent of dental caries and is also a causative agent of subacute infective endocarditis. The generation of proteolytic molecules, such as plasmin, may be important in the pathogenesis of endocarditis caused by S. mutans. In this study, we de...

journal_title：Biochemical and biophysical research communications

authors： Jones MN,Holt RG

更新日期：2004-09-10 00:00:00

abstract：:Endo-beta-1,4-xylanase X-I is a major hydrolase produced by the aleurone tissue of germinating barley grain. It was previously reported that this cytosolic enzyme is synthesized as an inactive precursor which is proteolytically processed to active forms upon its programmed cell death dependent release. We here demonst...

journal_title：Biochemical and biophysical research communications

authors： Van Campenhout S,Pollet A,Bourgois TM,Rombouts S,Beaugrand J,Gebruers K,De Backer E,Courtin CM,Delcour JA,Volckaert G

更新日期：2007-05-11 00:00:00

abstract：:Y-box or inverted CCAAT box-binding proteins are multifunctional regulators of transcription and translation of several genes. Although YB-1 has been shown to play a key role in cell cycle, to date, there is no direct evidence. We disrupted one allele of Chk-YB-1b in a chicken pre-B lymphocyte cell line, DT40. Compare...

journal_title：Biochemical and biophysical research communications

authors： Swamynathan SK,Varma BR,Weber KT,Guntaka RV

更新日期：2002-08-16 00:00:00

abstract：:Fusing recombinant proteins to highly soluble partners is frequently used to prevent aggregation of recombinant proteins in Escherichia coli. Moreover, co-overexpression of prokaryotic chaperones can increase the amount of properly folded recombinant proteins. To understand the solubility enhancement of fusion protein...

journal_title：Biochemical and biophysical research communications

authors： Douette P,Navet R,Gerkens P,Galleni M,Lévy D,Sluse FE

更新日期：2005-08-05 00:00:00

abstract：:The human poly(rC)-binding protein (PCBP) 2 is known to interact with enteroviral RNA. Here, the interaction of PCBP2 with RNA target sequences at the 5' end of the coxsackievirus B3 genome was investigated. Using the electrophoretic mobility shift assay and the yeast three-hybrid system, a short oligo(rC) tract conne...

journal_title：Biochemical and biophysical research communications

authors： Zell R,Ihle Y,Seitz S,Gündel U,Wutzler P,Görlach M

更新日期：2008-02-22 00:00:00

abstract：:The genetic encoding of synthetic or "non-natural" amino acids promises to diversify the functions and structures of proteins. We applied rapid codon-reassignment for creating Escherichia coli strains unable to terminate translation at the UAG "stop" triplet, but efficiently decoding it as various tyrosine and lysine ...

journal_title：Biochemical and biophysical research communications

authors： Mukai T,Yanagisawa T,Ohtake K,Wakamori M,Adachi J,Hino N,Sato A,Kobayashi T,Hayashi A,Shirouzu M,Umehara T,Yokoyama S,Sakamoto K

更新日期：2011-08-12 00:00:00