p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine.

abstract：:The effect of musk xylene on contents of both cytochrome P-450IA1 and cytochrome P-450IA2 in rat liver was investigated using Western blotting analysis. Rats were treated i.p. for five consecutive days with either 50, 100 or 200 mg musk xylene/kg body weight. Musk xylene increased both total cytochrome P-450 and cytoc...

journal_title：Biochemical and biophysical research communications

authors： Iwata N,Minegishi K,Suzuki K,Ohno Y,Kawanishi T,Takahashi A

更新日期：1992-04-15 00:00:00

abstract：:Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). The present study examined the molecular mechanism underlying ...

journal_title：Biochemical and biophysical research communications

authors： Auger C,Kim JH,Chabert P,Chaabi M,Anselm E,Lanciaux X,Lobstein A,Schini-Kerth VB

更新日期：2010-02-26 00:00:00

abstract：:The mechanism(s) involved in the generation of free radicals in human leukocytes by phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMP), lipopolysaccharide (LPS), arachidonic acid (AA), and recombinant-tumor necrosis factor-1-alpha (r-TNF-1 alpha) was investigated. Calmodulin antagonists, chlo...

journal_title：Biochemical and biophysical research communications

authors： Das UN,Padma M,Sagar PS,Ramesh G,Koratkar R

更新日期：1990-03-30 00:00:00

abstract：:The Znf131/ZNF131 protein belongs to the superfamily of POK proteins containing a BTB/POZ domain in its N-terminal part and 5 typical C2H2 zinc fingers and an additional C2HC zinc finger structure in its C-terminal region. In mouse and human two alternatively spliced transcripts are expressed from the Znf131/ZNF131 ge...

journal_title：Biochemical and biophysical research communications

authors： Trappe R,Buddenberg P,Uedelhoven J,Gläser B,Buck A,Engel W,Burfeind P

更新日期：2002-08-16 00:00:00

abstract：:Despite numerous studies on detergent-induced solubilization of membranes and on the underlying mechanisms associated with this process, very little is known regarding the selectivity of detergents for lipids during their extraction from membranes. To get insights about this phenomenon, solubilization of model bilayer...

journal_title：Biochemical and biophysical research communications

authors： Azouz M,Therrien A,Buré C,Tokarski C,Lecomte S,Lafleur M

更新日期：2020-10-15 00:00:00

abstract：:Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. We recently discovered that the immunosuppressant cyclosporin A (CsA) and its analogue lacking immunosuppressive function, NIM811, strongly suppress the replication of HCV in cell culture. Inhibition of a cellular replication cofactor, cyc...

journal_title：Biochemical and biophysical research communications

authors： Goto K,Watashi K,Murata T,Hishiki T,Hijikata M,Shimotohno K

更新日期：2006-05-12 00:00:00

abstract：:RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3. It contains a distinct SET domain, sometimes referred to as PR (PRDI-BF1 and RIZ1 homology) domain, that is responsible for its catalytic activity. We determined the solution structure of the PR domain from R...

journal_title：Biochemical and biophysical research communications

authors： Briknarová K,Zhou X,Satterthwait A,Hoyt DW,Ely KR,Huang S

更新日期：2008-02-15 00:00:00

abstract：:The frequency of p73 mutation is low in hematologic malignancies as well as solid tumors. Aberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphoblastic leukemia (ALL). In the present study, we scanned for mutations in the exons 4, 5, 6, and 7 of p73 gene. Using PC...

journal_title：Biochemical and biophysical research communications

authors： Sahu GR,Das BR

更新日期：2005-02-18 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:Tyrosinase catalyzes in mammals the first and rate-limiting step in the biosynthesis of the melanin, the main pigment of the skin. Pterins, heterocyclic compounds able to photoinduce oxidation of DNA and its components, accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder in wh...

journal_title：Biochemical and biophysical research communications

authors： Laura Dántola M,Gojanovich AD,Thomas AH

更新日期：2012-08-03 00:00:00

abstract：:A functional in vitro integration system for an integral membrane protein, SecG, comprising an efficient translation system supplemented with inverted membrane vesicles (IMV) was developed. When SecG was synthesized in the presence of IMV prepared from a DeltasecG strain (DeltaSecG IMV), the synthesized SecG was recov...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama K,Tokuda H

更新日期：2009-12-18 00:00:00

abstract：:The polyamines associated to human erythrocytes from healthy donors are mainly localized intracellularly. In fact chromatography of the erythrocytes on a resin which has a high affinity and capacity for polyamines does not affect the amount of polyamines associated to the erythrocytes. The low ability of spermine to a...

journal_title：Biochemical and biophysical research communications

authors： Tadolini B,Hakim G,Orlandini G,Casti A

更新日期：1986-02-13 00:00:00

abstract：:Posttranslational histone modifications play an important role in modulating gene expression and chromatin structure. Here we report the identification of histone H3K79 dimethylation in the simple eukaryote Dictyostelium discoideum. We have deleted the D. discoideum Dot1/KMT4 homologue and demonstrate that it is the s...

journal_title：Biochemical and biophysical research communications

authors： Müller-Taubenberger A,Bönisch C,Fürbringer M,Wittek F,Hake SB

更新日期：2011-01-28 00:00:00

abstract：:Neuropeptide Y (NPY) is known to induce robust feeding through the action of NPY receptors in the hypothalamus. Among the subtypes of NPY receptors, Y(1) receptors may play a key role in feeding regulation. In the present study, we demonstrated that a novel Y(1) antagonist, J-104870, shows high selectivity and potency...

journal_title：Biochemical and biophysical research communications

authors： Kanatani A,Kanno T,Ishihara A,Hata M,Sakuraba A,Tanaka T,Tsuchiya Y,Mase T,Fukuroda T,Fukami T,Ihara M

更新日期：1999-12-09 00:00:00

abstract：:miRNAs are recently found playing important roles in osteogenesis. In this study, we identified that miR-222-3p decreased during osteogenic differentiation of human mesenchymal stem cells (hBMSCs) using Quantitative Real-Time Reverse Transcription PCR (qRT-PCR). Furthermore, we investigated the effect of miR-222-3p on...

journal_title：Biochemical and biophysical research communications

authors： Yan J,Guo D,Yang S,Sun H,Wu B,Zhou D

更新日期：2016-02-12 00:00:00

abstract：:The cardiotoxin analogue III (CTX III), isolated from the Taiwan Cobra venom (Naja naja atra), is a sixty amino acid, all beta-sheet protein. The 2,2,2-trifluoro ethanol (TFE) induced unfolding of CTX III is studied under acidic conditions (pH 2.5). Using circular dichroism, 1-anilino-8-napthalene sulphonic acid bindi...

journal_title：Biochemical and biophysical research communications

authors： Kumar TK,Jayaraman G,Lee CS,Sivaraman T,Lin WY,Yu C

更新日期：1995-02-15 00:00:00

abstract：:KK mice are genetically diabetic animals, showing glucose intolerance and insulin resistance. We examined the effects of 3,3',5-triiodo-L-thyronine (T3) on the blood glucose level and on mRNA levels of muscle cell differentiation markers in hyperglycemic KK mice. T3 treatment (T1, 1 mg; T3, 3 mg; T10, 10 mg/kg/day) of...

journal_title：Biochemical and biophysical research communications

authors： Shimokawa T,Kato M,Shioduka K,Irie J,Ezaki O

更新日期：1997-06-27 00:00:00

abstract：:We have obtained the optimized geometrical structure of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium dipolar ion and investigated its geometric and electric changes during decarboxylation process by the MNDO-PM3 method, a molecular orbital method. The salient features of the optimized structure are that the dih...

journal_title：Biochemical and biophysical research communications

authors： Nakajima Y,Sakagishi Y,Shiibashi M,Suzuki Y,Kato H

更新日期：1993-08-31 00:00:00

abstract：:A sample of highly oriented Na-hyaluronate was prepared with a wet--spinning method and equilibrated to 75% relative humidity. Its proton NMR spectrum was recorded as a function of the angle theta between the hyaluronate helix axis and the external magnetic field. It appeared as a singlet with an angle-dependent line ...

journal_title：Biochemical and biophysical research communications

authors： Lahajnar G,Rupprecht A

更新日期：1986-11-26 00:00:00

abstract：:The endothelin system consists of three ligands (ET-1, ET-2 and ET-3) and at least two receptors (ETA and ETB). In mice ET-2 counterpart is a peptide originally called "vasoactive intestinal contractor" (VIC) for this reason, this peptide is frequently named ET-2/VIC. In intestinal villi, fibroblasts-like cells expres...

journal_title：Biochemical and biophysical research communications

authors： Bianchi M,Adur J,Takizawa S,Saida K,Casco VH

更新日期：2012-01-27 00:00:00

abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

journal_title：Biochemical and biophysical research communications

authors： Kim HJ,Byun SJ,Kim TY

更新日期：2004-04-23 00:00:00

abstract：:In the medical field, attached bacteria can cause infections associated with catheters, incisions, burns, and medical implants especially in immunocompromised patients. The problem is exacerbated by the fact that attached bacteria are ∼1000 times more resistant to antibiotics than planktonic cells. The rapid spread of...

journal_title：Biochemical and biophysical research communications

authors： Badawy HT,Pasetto P,Mouget JL,Pilard JF,Cutright TJ,Milsted A

更新日期：2013-09-06 00:00:00

abstract：:The effect of a cryptic splice acceptor (cSA) site located at the end of the extended packaging signal in murine leukemia virus (MLV)-based vectors was investigated. Although this cSA is also present in wild type MLV, it was found to result in a smaller transcript in which the packaging signal (Psi) had been removed b...

journal_title：Biochemical and biophysical research communications

authors： Pambalk K,Hohenadl C,Salmons B,Günzburg WH,Renner M

更新日期：2002-04-26 00:00:00

abstract：:Kinetic studies on the cyclization of 2,3(S)-oxido and 2,3(S):22(S),23-dioxido[14C]squalene catalyzed by liver oxidosqualene-lanosterol cyclase revealed a specificity (in terms of V/Km) of the enzyme for the diepoxide. The specificity ratio was dependent on the enzyme preparation, i.e. purified or microsomal, and was ...

journal_title：Biochemical and biophysical research communications

authors： Boutaud O,Dolis D,Schuber F

更新日期：1992-10-30 00:00:00

abstract：:We had earlier reported a uteroglobin promoter-binding factor in nuclei from progesterone-stimulated rabbit endometrium that was inhibited by a factor in nuclei without progesterone stimulation or from non-target tissues (Rider, V., and Bullock, D.W., 1988. Biochem. Biophys. Res. Comm. 156, 1368-1375). In the course o...

journal_title：Biochemical and biophysical research communications

authors： Daniel PB,Molloy C,Rayner JC,Hill AM,Bullock DW

更新日期：1994-10-14 00:00:00

abstract：:Stress associated proteins (SAPs) in plants contain A20-type zinc finger (A20_ZF) domains and are involved with abiotic stress response. A20-type zinc finger domains in animals reportedly recognize ubiquitin as a regulatory signal in cell. However, it remains unclear whether A20_ZF domains in plants perform similar ro...

journal_title：Biochemical and biophysical research communications

authors： Choi H,Han S,Shin D,Lee S

更新日期：2012-03-09 00:00:00

abstract：:Human serum albumin (HSA) has been used to extend the serum half-lives of various protein therapeutics through genetic fusion because HSA exhibits an exceptionally long circulation time as a result of neonatal Fc receptor (FcRn)-mediated recycling. As another serum half-life extender, the human antibody Fab SL335 that...

journal_title：Biochemical and biophysical research communications

authors： Cho SY,Han J,Cha SH,Yoon SI

更新日期：2020-06-11 00:00:00

abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

更新日期：2011-12-02 00:00:00

abstract：:C1 inhibitor (C1IN) is a multi-facet serine protease inhibitor in the plasma cascades, inhibiting several proteases, notably, regulates both complement and contact system activation. Despite huge advancements in the understanding of C1IN based on biochemical properties and its roles in the plasma cascades, the phyloge...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2014-07-18 00:00:00

abstract：:Whereas sitosterol and 24(28)-methylene cycloartanol were competitive inhibitors (with Ki = 26 microM and 14 microM, respectively), 24(R,S)-25-epiminolanosterol was found to be a potent non-competitive inhibitor (Ki = 3.0 nM) of the S-adenosyl-L-methionine-C-24 methyl transferase from sunflower embryos. Because the gr...

journal_title：Biochemical and biophysical research communications

authors： Nes WD,Janssen GG,Norton RA,Kalinowska M,Crumley FG,Tal B,Bergenstrahle A,Jonsson L

更新日期：1991-05-31 00:00:00