Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase.

abstract：:The influence of leucine starvation on the subcellular location of leucyl-tRNA synthetase in Escherichia coli was examined in a leucine auxotrophic strain by sucrose density sedimentation analysis. Analysis of the subcellular distribution of leucyl-tRNA synthetase activity revealed that during unrestricted growth, the...

journal_title：Biochemical and biophysical research communications

authors： Williamson RM

更新日期：1993-02-15 00:00:00

abstract：:miRNAs are approximately 21nt non-coding RNAs and play important roles in plant development and response to stress. Symbiotic nitrogen fixation (SNF) is agronomically important for reducing the need of nitrogen fertilizers. The soybean root nodule is the place where SNF takes place. To identify miRNAs that are possibl...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Li P,Cao X,Wang X,Zhang A,Li X

更新日期：2009-01-23 00:00:00

abstract：:In hair follicle cells APCDD1 inhibits the canonical WNT/β-Catenin pathway and its inactivation is associated with an autosomal dominant form of hair loss. We analyzed the role of APCDD1 for the osteogenic differentiation in dental follicle cells (DFCs) and identified a new and surprising function. Contrarily to hair ...

journal_title：Biochemical and biophysical research communications

authors： Viale-Bouroncle S,Klingelhöffer C,Ettl T,Morsczeck C

更新日期：2015-02-13 00:00:00

abstract：:Betulin, a natural product isolated from the bark of the birch trees, exhibits multiple anticancer effects. Activation of mTOR signaling pathway has been found in numerous cancers, including renal cell carcinoma (RCC). Here, we attempted to study whether mTOR signaling was essential for betulin to treat RCC. Based on ...

journal_title：Biochemical and biophysical research communications

authors： Cheng W,Ji S,Zhang H,Han Z,Liu Q,Wang J,Ping H

更新日期：2017-01-22 00:00:00

abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

journal_title：Biochemical and biophysical research communications

authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

更新日期：1990-11-15 00:00:00

abstract：:Human adipose-derived mesenchymal stem cells (hASCs) are attractive cell source for skin tissue engineering. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted cluster hASC in a skin wound animal model. The hASCs were cultured in monolayer or clusters. The LLLT, hASC...

journal_title：Biochemical and biophysical research communications

authors： Park IS,Chung PS,Ahn JC

更新日期：2015-07-03 00:00:00

abstract：:Deoxynucleoside triphosphate concentrations in Chinese hamster ovary cell lines, CHO-K1 and Mut 8-16, were examined following exposure of cells to UV or dimethylsulfate. Marked decreases in dCTP were observed 2 hr after exposure to both mutagens. In contrast, dTTP concentrations increased with increased cell killing a...

journal_title：Biochemical and biophysical research communications

authors： Newman CN,Miller JH

更新日期：1983-07-18 00:00:00

abstract：:Methylglyoxal (MG), a cytotoxic by-product produced mainly from triose phosphates, is used as a substrate by glyoxalase I. In this paper, we report on the estimation of MG level in plants which has not been reported earlier. We show that MG concentration varies in the range of 30-75 microM in various plant species and...

journal_title：Biochemical and biophysical research communications

authors： Yadav SK,Singla-Pareek SL,Ray M,Reddy MK,Sopory SK

更新日期：2005-11-11 00:00:00

abstract：:Adherens junction-associated protein-1 (AJAP1), also called SHREW1, was first discovered as a novel component of adherens junctions in 2004. In later studies, AJAP1 was found to suppress invasion and predict recurrence of some tumors. Apart from its function as a putative tumor suppressor, AJAP1 is still poorly unders...

journal_title：Biochemical and biophysical research communications

authors： Zhang M,Zhou X,Jiang W,Li M,Zhou R,Zhou S

更新日期：2020-04-16 00:00:00

abstract：:Necrotic cells are known to develop characteristic membrane blebs. We measured protein concentration within necrotic blebs and found that it can be reduced by as much as twenty-fold compared to the main cell body (CB). These results raise two questions: 1. Why do proteins vacate the bleb? 2. How can osmotic equilibriu...

journal_title：Biochemical and biophysical research communications

authors： Rana PS,Mudrak NJ,Lopez R,Lynn M,Kershner L,Model MA

更新日期：2017-10-21 00:00:00

abstract：:The codon-reading properties of wobble-position variants of the unmodified form of Escherichia coli tRNASer1 (the UGA anticodon) were measured in a cell-free translation system. Two variants, with the AGA and CGA anticodons, each exclusively read a single codon, UCU and UCG, respectively. The only case of efficient wo...

journal_title：Biochemical and biophysical research communications

authors： Takai K,Takaku H,Yokoyama S

更新日期：1999-04-21 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n=6), low dose IL-6 (LoIL-6; n=6), or saline (CON; n=6) infused into one femoral artery for 3h. Muscle biopsies were obtained from t...

journal_title：Biochemical and biophysical research communications

authors： Febbraio MA,Steensberg A,Fischer CP,Keller C,Hiscock N,Pedersen BK

更新日期：2002-09-06 00:00:00

abstract：:Yeast cell viability and concentration are the crucial factors affecting product quality in food industry and bio-fuel production, as well as the evaluation basis for environmental toxic compounds. To overcome the drawbacks of existing methods, including high error, false positive and low automation, we propose a high...

journal_title：Biochemical and biophysical research communications

authors： Li G,Wei M,Sun J,Zhang Y,Zhang R

更新日期：2020-05-07 00:00:00

abstract：:A new 1,25-dihydroxyvitamin D3 analog, 22-oxa-1,25(OH)2D3, which may have pharmaceutical use, e.g., in the treatment of psoriasis, was studied using cultured MG-63 human osteosarcoma cells. We found that the new compound binds to 1,25-dihydroxyvitamin D receptors and regulates receptor mRNA levels like the natural lig...

journal_title：Biochemical and biophysical research communications

authors： Valaja T,Mahonen A,Pirskanen A,Mäenpää PH

更新日期：1990-06-15 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various normal and neoplastic tissues. Even if the physiological function(s) of PTHrP is unclear, evidence suggests that the protein may participate in the local regulation of smooth muscle contractility. We show here that PTHrP is produced in endothelial cell...

journal_title：Biochemical and biophysical research communications

authors： Rian E,Jemtland R,Olstad OK,Endresen MJ,Grasser WA,Thiede MA,Henriksen T,Bucht E,Gautvik KM

更新日期：1994-01-28 00:00:00

abstract：:Of two major isoforms of angiotensin II receptors, AT1 and AT2, biological roles of AT2 remain unclear. Using vascular smooth muscle cells, we investigated the regulation of expression of AT2 by growth factors in comparison with that of AT1. The cultured rat aorta smooth muscle cells had detectable AT2 binding sites, ...

journal_title：Biochemical and biophysical research communications

authors： Kambayashi Y,Bardhan S,Inagami T

更新日期：1993-07-15 00:00:00

abstract：:Polyacrylamide gel electrophoresis and isoelectrofocusing followed by immunoblotting technique with an anti-human retinol-binding protein (RBP) serum were used to study holo-RBP and apo-RBP in human plasma. Three observations were made the technique allowed for the first time to directly and quantitatively analyse hol...

journal_title：Biochemical and biophysical research communications

authors： Siegenthaler G,Saurat JH

更新日期：1987-03-13 00:00:00

abstract：:The localization of gene expression of a low M(r) GTP-binding protein, ram p25, was examined throughout the entire brain of adult rat by in situ hybridization. ram-mRNA was expressed predominantly in anterior and intermediate lobes of pituitary gland (hypophysis), and weakly in hippocampal formation. In other parts of...

journal_title：Biochemical and biophysical research communications

authors： Nagata K,Sakagami H,Kondo H,Nozawa Y

更新日期：1995-12-26 00:00:00

abstract：:An ubiquinone-binding protein (QP) was purified from mitochondrial NADH-ubiquinone reductase (Complex I). Complex I was separated into 3 fragments: a fraction of hydrophobic proteins, that of soluble iron-sulfur protein (IP) and soluble NADH dehydrogenase of flavoprotein by a procedure involving the resolution with DO...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Ozawa T

更新日期：1986-08-14 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis and its activation during T cell receptor stimulation has recently been reported. In this study, we examined the role of AMPK in interleukin (IL)-2 production in T cells. Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small...

journal_title：Biochemical and biophysical research communications

authors： Jhun BS,Lee JY,Oh YT,Lee JH,Choe W,Baik HH,Kim SS,Yoon KS,Ha J,Kang I

更新日期：2006-12-29 00:00:00

abstract：:The alkalization of intracellular pH (pHin) advances together with enhancement of aerobic glycolysis within tumor cells (the Warburg effect), and that is responsible for the progression of tumor malignancy together with hypoxia and angiogenesis. But how they correlate each other during tumor growth is poorly understoo...

journal_title：Biochemical and biophysical research communications

authors： Tanaka S,Harada H,Hiraoka M

更新日期：2015-09-04 00:00:00

abstract：:The fibroblast growth factors (FGFs) are involved in hematopoiesis and tumorigenesis. However, little is known about the contribution of the FGFs identified within the past 10 years to leukemogenesis. To elucidate whether these FGFs (FGF-8, -9, -10, -11, -12, -13, -14, -16, -17, -18, -19, -20, and -21) are expressed i...

journal_title：Biochemical and biophysical research communications

authors： Nezu M,Tomonaga T,Sakai C,Ishii A,Itoga S,Nishimura M,Matsuo Y,Tagawa M,Nomura F

更新日期：2005-09-30 00:00:00

abstract：:Explaining why type I collagens are preferentially preserved in the geological time scale remains a challenge. Several pieces of evidence indicate that its rich content in the bone and its unique, stable structure played key roles in its preservation. By considering the distinct thermal stability of amino acids, we re...

journal_title：Biochemical and biophysical research communications

authors： Wang SY,Cappellini E,Zhang HY

更新日期：2012-05-25 00:00:00

abstract：:The cytoplasmic domain of the neural cell adhesion molecule (NCAM) contains multiple phosphorylation sites. We report here that in addition to serine and threonine residues a tyrosine of the NCAM180 isoform is phosphorylated as shown by phosphoamino acid analysis. Exchange of the only cytoplasmic tyrosine at position ...

journal_title：Biochemical and biophysical research communications

authors： Diestel S,Laurini C,Traub O,Schmitz B

更新日期：2004-09-10 00:00:00

abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

journal_title：Biochemical and biophysical research communications

authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

更新日期：2019-04-30 00:00:00

abstract：:Myotonic dystrophy (DM) is an autosomal dominant human disorder, caused by the abnormal expansion of a CTG trinucleotide repeat in the 3' untranslated region of a protein kinase gene (DMPK). Muscle symptoms are a common feature of the disorder and in the adult onset cases there are increased patterns of muscle fibre d...

journal_title：Biochemical and biophysical research communications

authors： Okoli G,Carey N,Johnson KJ,Watt DJ

更新日期：1998-05-29 00:00:00

abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

journal_title：Biochemical and biophysical research communications

authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

更新日期：2007-11-23 00:00:00

abstract：:Light-induced conformational changes occurring at the cytosolic surface of rhodopsin were investigated by performing limited digestions of native and illuminated visual pigment with thermolysin, Arg-C endoproteinase, papain and proteinase K. A higher susceptibility of the extradiscal regions of the bleached pigment to...

journal_title：Biochemical and biophysical research communications

authors： Pellicone C,Nullans G,Cook NJ,Virmaux N

更新日期：1985-03-29 00:00:00

abstract：:A method has been developed for the specific amplification and cloning of human hprt cDNA which can be used for mutant sequence analysis. Messenger RNA is isolated from TK6 lymphoblasts and is used to produce a first strand cDNA with reverse transcriptase primed with oligo dT. Second strand synthesis and subsequent am...

journal_title：Biochemical and biophysical research communications

authors： Simpson D,Crosby RM,Skopek TR

更新日期：1988-02-29 00:00:00

abstract：:Group II chaperonins (Cpns) are essential mediators of cellular protein folding in eukaryotes and archaea. They consist of two back-to-back rings forming symmetrical cavities in which non-native substrates undergo appropriate folding, but the primary structural basis for the double ring formation remains unclear. To a...

journal_title：Biochemical and biophysical research communications

authors： Luo H,Zhang P,Robb FT

更新日期：2011-09-23 00:00:00