当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Over expression of the murine myotonic dystrophy protein kinase in the mouse myogenic C2C12 cell line leads to inhibition of terminal differentiation.

Over expression of the murine myotonic dystrophy protein kinase in the mouse myogenic C2C12 cell line leads to inhibition of terminal differentiation.

Abstract：

:Myotonic dystrophy (DM) is an autosomal dominant human disorder, caused by the abnormal expansion of a CTG trinucleotide repeat in the 3' untranslated region of a protein kinase gene (DMPK). Muscle symptoms are a common feature of the disorder and in the adult onset cases there are increased patterns of muscle fibre degeneration and regeneration. In the congenitally affected infants there is a failure of muscle maturation, with the histological presence of numerous immature fibres. However, the pathological mechanism in both forms of the disease is unclear. We report that over-expression of the murine dmpk gene, in a murine myogenic cell line, leads to markedly reduced levels of fusion to the terminally differentiated state. These findings complement recently published data using a heterologous expression/cell system and may have implications for the understanding of the disease process in this disorder.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Okoli G,Carey N,Johnson KJ,Watt DJ

doi

10.1006/bbrc.1998.8723

subject

Has Abstract

pub_date

1998-05-29 00:00:00

pages

905-11

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)98723-X

journal_volume

246

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • 1,25-Dihydroxyvitamin D3 inhibits selectively the mitogenic stimulation of mouse medullary thymocytes.

    abstract：:Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90394-2

    authors： Ravid A,Koren R,Novogrodsky A,Liberman UA

    更新日期：1984-08-30 00:00:00

  • On the enigma of pain and hyperalgesia: A molecular perspective.

    abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2006.12.032

    authors： Haddad JJ

    更新日期：2007-02-09 00:00:00

  • Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells.

    abstract：:Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration sta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1394

    authors： Watanabe S,Hirose M,Wang XE,Maehiro K,Murai T,Kobayashi O,Nagahara A,Sato N

    更新日期：1994-03-30 00:00:00

  • Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells.

    abstract：:In resting mesangial cells, angiotensin II and the calcium ionophore A23187 stimulated prostaglandin E2 (PGE2) formation. After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified res...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90371-s

    authors： Pfeilschifter J,Mühl H

    更新日期：1990-06-15 00:00:00

  • Amphibian tachykinin precursor.

    abstract：:The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami. Their amino acid sequences are DDTEDLANKFIGLM-NH(2) (named tachyk...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.09.150

    authors： Li J,Liu T,Xu X,Wang X,Wu M,Yang H,Lai R

    更新日期：2006-12-01 00:00:00

  • The mechanism for apo-B mRNA editing is deamination.

    abstract：:Apolipoprotein (apo-) B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon. To investigate this editing mechanism, [a-32P] and [5-3H] CTP were incorporated into synthetic apo-B RNA. After the substrate had been edited extensively in vitro by a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2172

    authors： Johnson DF,Poksay KS,Innerarity TL

    更新日期：1993-09-30 00:00:00

  • Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells.

    abstract：:Cysteinyl leukotrienes (cysLTs), which include leukotriene C4 (LTC4), are the predominant class of LTs synthesized by mast cells. CysLTs can induce many of the abnormalities seen in asthma. LTC4 is generated by the conjugation of LTA4 with reduced glutathione (GSH) by LTC4 synthase. During screening of the effects of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.08.081

    authors： Seki K,Hisada T,Kawata T,Kamide Y,Dobashi K,Yamada M,Mori M,Okajima F,Ishizuka T

    更新日期：2013-09-27 00:00:00

  • An EGF-like peptide sequence from Dictyostelium enhances cell motility and chemotaxis.

    abstract：:Dictyostelium discoideum possesses more EGF-like (EGFL) domains than any other sequenced eukaryote. Here we show that a synthetic EGFL peptide (DdEGFL1) based upon an amino acid sequence from a cysteine-rich Dictyostelium protein, functions extracellularly to enhance random cell motility and cAMP-mediated chemotaxis i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.081

    authors： Huber R,O'Day DH

    更新日期：2009-02-06 00:00:00

  • MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells.

    abstract：BACKGROUND:Resistin is associated with insulin resistance, and determining its developmental and molecular mechanisms may help the development of novel treatments. MicroRNAs (miRNAs) are involved in many physiological and pathological processes as negative regulators. However, it remains unclear whether miRNAs play a r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.02.034

    authors： Wen F,Yang Y,Jin D,Sun J,Yu X,Yang Z

    更新日期：2014-03-07 00:00:00

  • ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity.

    abstract：PURPOSE:Recently, the newly identified embryonic stem cell marker, Zinc finger and SCAN domain containing 4 gene (ZSCAN4), which plays a key role in genomic stability by regulating telomere elongation, was shown to co-localize with TRF1 foci. This suggests that the interaction of ZSCAN4 with TRF1 functions in regulatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.09.107

    authors： Lee K,Gollahon LS

    更新日期：2015-10-30 00:00:00

  • E3 ubiquitin ligase ATL61 acts as a positive regulator in abscisic acid mediated drought response in Arabidopsis.

    abstract：:Abscisic acid (ABA) is an important plant hormone that mediates abiotic stresses in plant growth and development. A number of E3 ligases have been reported to be involved in ABA signaling pathway. In this study, we identified a C3H2C3 RING-type E3 ligase, Arabidopsis thaliana Tόxicos en Levadura 61 (ATL61), which regu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.067

    authors： Yang R,Wang T,Shi W,Li S,Liu Z,Wang J,Yang Y

    更新日期：2020-07-23 00:00:00

  • Growth hormone-induced alteration of morphology and tubulin expression in 3T3 preadipose cells.

    abstract：:Effects of growth hormone on morphology and cytoskeletal protein expression were examined in 3T3-F442A preadipocytes in serum-free medium. Between 2 and 5 days of culture 2 nM methionyl human growth hormone converted 3T3-F442A cells from a flat fibroblastic morphology to a rounded form with numerous membrane convoluti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92306-1

    authors： Guller S,Corin RE,Wu KY,Sonenberg M

    更新日期：1989-09-15 00:00:00

  • Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

    abstract：:Sma- and MAD-related protein 3 (Smad3) plays crucial roles in the transforming growth factor-beta (TGF-beta)-mediated signaling pathway, which produce a variety of cellular responses, including cell proliferation and differentiation. In our previous study, we demonstrated that protein inhibitor of activated STATy (PIA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.116

    authors： Imoto S,Ohbayashi N,Ikeda O,Kamitani S,Muromoto R,Sekine Y,Matsuda T

    更新日期：2008-05-30 00:00:00

  • Retinol-binding protein in human serum: conformational changes induced by retinoic acid binding.

    abstract：:Polyacrylamide gel electrophoresis and isoelectrofocusing followed by immunoblotting technique with an anti-human retinol-binding protein (RBP) serum were used to study holo-RBP and apo-RBP in human plasma. Three observations were made the technique allowed for the first time to directly and quantitatively analyse hol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91370-2

    authors： Siegenthaler G,Saurat JH

    更新日期：1987-03-13 00:00:00

  • Molecular cloning and expression of mouse procalcitonin.

    abstract：:The nucleotide sequence for mouse calcitonin was determined from a cDNA obtained using a polymerase chain reaction (PCR) based method, the rapid amplification of cDNA ends (RACE)-PCR. Primers designed from highly conserved regions in the coding sequences of known rat and human calcitonin cDNAs were used to amplify cal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1371

    authors： Rehli M,Luger K,Beier W,Falk W

    更新日期：1996-09-13 00:00:00

  • p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETbeta in irradiated MOLT-4 cells.

    abstract：:We have reported previously that X-irradiated MOLT-4 cells during their rapid cell death exhibited dose and time dependently a new protein named p41 detected by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). An antibody, AM-1, raised against partial peptide of p41 stained two spots, p41 and p42, unexpe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3860

    authors： Morita A,Suzuki N,Matsumoto Y,Hirano K,Enomoto A,Zhu J,Sakai K

    更新日期：2000-11-30 00:00:00

  • Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.

    abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.135

    authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

    更新日期：2017-01-22 00:00:00

  • Atrial natriuretic factor inhibits vasopressin secretion from rat posterior pituitary.

    abstract：:The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91918-7

    authors： Obana K,Naruse M,Inagami T,Brown AB,Naruse K,Kurimoto F,Sakurai H,Demura H,Shizume K

    更新日期：1985-11-15 00:00:00

  • Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice.

    abstract：:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.145

    authors： Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

    更新日期：2013-11-08 00:00:00

  • Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

    abstract：:We have used site-directed mutagenesis to investigate the requirement of cysteine residues in the extracellular domains of the human VIP 1 receptor for binding VIP. Cys37, Cys50, Cys63, Cys72, Cys86, Cys105 and Cys122 (N-terminal extracellular domain), Cys208 and Cys215 (second extracellular loop) and Cys288 (third ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1897

    authors： Gaudin P,Couvineau A,Maoret JJ,Rouyer-Fessard C,Laburthe M

    更新日期：1995-06-26 00:00:00

  • The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase.

    abstract：:Methanol dehydrogenase is a heterotetrameric enzyme containing the prosthetic group pyrroloquinoline quinone (PQQ), which catalyzes the oxidation of methanol to formaldehyde. The crystal structure of methanol dehydrogenase from Methylophilus W3A1, previously determined at high resolution, exhibits a non-planar configu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.02.107

    authors： Li J,Gan JH,Mathews FS,Xia ZX

    更新日期：2011-03-25 00:00:00

  • Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.

    abstract：:The Janus kinase (JAK) and signal transducers and activators of transcription (STAT) signal cascades are major pathways that mediate the inflammatory functions of interferon-gamma (IFN-gamma), an important pro-inflammatory cytokine. Therefore, regulation of JAK/STAT signaling should modulate IFN-gamma-mediated inflamm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.025

    authors： Jeon SB,Ji KA,You HJ,Kim JH,Jou I,Joe EH

    更新日期：2005-03-11 00:00:00

  • A novel, anchorless streptococcal surface protein that binds to human immunoglobulins.

    abstract：:We have characterized a novel surface protein from urea extract of whole cells of group A Streptococcus pyogenes (GAS). A major protein band (35kD) was found to hybridize with human IgG by Western blotting. A search of the N-terminal amino acid sequence of this protein by using the GAS genome sequence database reveale...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02078-8

    authors： Kawabata S,Tamura Y,Murakami J,Terao Y,Nakagawa I,Hamada S

    更新日期：2002-09-06 00:00:00

  • Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1.

    abstract：:The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91357-i

    authors： Ohmichi M,Decker SJ,Pang L,Saltiel AR

    更新日期：1991-08-30 00:00:00

  • KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter.

    abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is a gamma-herpesvirus that is frequently associated with the formation of tumors like Kaposi's sarcoma and primary effusion lymphomas. KSHV RTA is required for lytic replication/reactivation in KSHV-infected cells. We developed an inducible RTA expression cell line to se...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.092

    authors： Yada K,Do E,Sakakibara S,Ohsaki E,Ito E,Watanabe S,Ueda K

    更新日期：2006-06-23 00:00:00

  • Hormonal effects on the development changes of mouse small intestinal glycolipids.

    abstract：:The composition of intestinal glycosphingolipids during normal and hormone-perturbed development was investigated. The concentrations of glycosphingolipids of mouse small intestine were affected by the injection of thyroxine or cortisone during suckling and weaning periods. GDla was reduced by the hormonal treatment a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90898-2

    authors： Sato E,Fujie M,Uezato T,Fujita M,Nishimura K

    更新日期：1984-03-30 00:00:00

  • The design, synthesis, and biochemical evaluation of derivatives of biphenyl sulfamate-based compounds as novel inhibitors of estrone sulfatase.

    abstract：:We report the initial results of our study into the use of a potential transition state (TS) of the reaction catalyzed by the enzyme estrone sulfatase (ES) in the design of a series of simple 4'-O-sulfamoyl-4-biphenyl-based compounds as novel inhibitors of ES. The results of the study show that these compounds are: po...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,收录出版

    doi：10.1016/S0006-291X(02)00444-8

    authors： Ahmed S,James K,Owen CP

    更新日期：2002-05-31 00:00:00

  • Biphasic influence of pravastatin on human cardiac microvascular endothelial cell functions under pathological and physiological conditions.

    abstract：:HMG-CoA reductase inhibitor statins are used to treat patients with hypercholesterolemia. The pleiotropic effects of statins have been recently extended to the regulation of angiogenesis. However, the observations on the effects of statins on endothelial cells seem to be contradictory. In this work, we systematically ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.090

    authors： Hu K,Wan Q

    更新日期：2019-04-02 00:00:00

  • A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels.

    abstract：:A 64-year-old Japanese male suffering from very slowly progressive amyloidosis was studied by immunohistopathologic, mass spectrometric, and molecular genetic methods. After confirming the immunoreactivity of transthyretin (TTR) in the amyloid deposits using an anti-TTR polyclonal antibody, matrix-assisted laser desor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1514

    authors： Terazaki H,Ando Y,Misumi S,Nakamura M,Ando E,Matsunaga N,Shoji S,Okuyama M,Ideta H,Nakagawa K,Ishizaki T,Ando M,Saraiva MJ

    更新日期：1999-10-22 00:00:00

  • Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.

    abstract：:Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. Several compounds targeting IAPs and inducing cell death in cancer cells have been developed. Some of these are synthesized mimicking the N-terminal tetrapeptide sequence of Smac/DIABLO, the natural endogenous I...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.139

    authors： Cossu F,Mastrangelo E,Milani M,Sorrentino G,Lecis D,Delia D,Manzoni L,Seneci P,Scolastico C,Bolognesi M

    更新日期：2009-01-09 00:00:00