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Growth hormone-induced alteration of morphology and tubulin expression in 3T3 preadipose cells.

Abstract：

:Effects of growth hormone on morphology and cytoskeletal protein expression were examined in 3T3-F442A preadipocytes in serum-free medium. Between 2 and 5 days of culture 2 nM methionyl human growth hormone converted 3T3-F442A cells from a flat fibroblastic morphology to a rounded form with numerous membrane convolutions. Growth hormone treated cultures manifested a 30-40% reduction in cell volume. Growth hormone induced changes in morphology and volume preceded and were independent of lipogenesis. In cells treated with growth hormone, expression of alpha and beta-tubulin as determined by Western blotting was found to increase approximately 50% within 72 h as compared to untreated cells. After 7 days, tubulin levels in growth hormone treated cells were approximately 40% of control levels. This indicated that morphological changes and alteration of tubulin expression were signatures of growth hormone action on 3T3-F442A cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Guller S,Corin RE,Wu KY,Sonenberg M

doi

10.1016/0006-291x(89)92306-1

subject

Has Abstract

pub_date

1989-09-15 00:00:00

pages

895-901

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92306-1

journal_volume

163

pub_type

杂志文章

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