Gastric cytoprotection by intracisternal interleukin-1 beta in the rat.

abstract：:After a peripheral nerve injury, the remaining Schwann cells undergo proliferation and adopt a migratory phenotype to prepare for the regeneration of nerves. Celsr2 has been reported to play an important role in the development and maintenance of the function of the nervous system. However, the role and mechanism of C...

journal_title：Biochemical and biophysical research communications

authors： Zhou X,Zhan Z,Tang C,Li J,Zheng X,Zhu S,Qi J

更新日期：2020-12-17 00:00:00

abstract：:Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy has not been previously repo...

journal_title：Biochemical and biophysical research communications

authors： Ock S,Park S,Lee J,Kim J

更新日期：2019-08-20 00:00:00

abstract：:Lysine-specific methyltransferase Set7/9 (KMT7) belongs to the SET domain family of proteins. Besides the SET domain, Set7/9 also contains a so-called MORN (Membrane Occupation and Recognition Nexus) domain whose function in high eukaryotes is largely unknown. Set7/9 has been shown to specifically methylate both histo...

journal_title：Biochemical and biophysical research communications

authors： Vasileva E,Shuvalov O,Petukhov A,Fedorova O,Daks A,Nader R,Barlev N

更新日期：2020-05-14 00:00:00

abstract：:Streptococcus pneumoniae is a major pathogen of community-acquired pneumonia and one of its major virulence factors is pneumolysin, which functions as a cholesterol-dependent cytolytic pore-forming toxin. In this study, we identified the ply-like gene spd0729 in a BLAST search. Unexpectedly, hemolytic and cytotoxic as...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Minamide Y,Terao Y,Isoda R,Ogawa T,Yokota S,Hamada S,Kawabata S

更新日期：2009-12-04 00:00:00

abstract：:A new method for complementing existing protein chemical techniques for the assignment of S-S bridge positions in amino-acid sequences is described. The principle of the method is the direct examination of the masses of protein fragments, obtained by chemical or enzymatic degradation. Proteins are digested under condi...

journal_title：Biochemical and biophysical research communications

authors： Morris HR,Pucci P

更新日期：1985-02-15 00:00:00

abstract：:To analyze the immune responses of DNA vaccine encoded different gene fragments of severe acute respiratory syndrome coronavirus (SARS-Cov), SARS-Cov gene fragments of membrane (M), nucleocapsid (N), spike a (Sa), and spike b (Sb) proteins were cloned into pcDNA3.1 (Invitrogen) vector to form plasmids pcDNAM, pcDNAN, ...

journal_title：Biochemical and biophysical research communications

authors： Wang Z,Yuan Z,Matsumoto M,Hengge UR,Chang YF

更新日期：2005-02-04 00:00:00

abstract：:Bovine pulmonary artery endothelial cells (BPAEC) were prelabeled with [3H]choline or [3H]myristic acid to selectively label endogenous phosphatidylcholine. BPAEC were stimulated with ATP and bradykinin (BK), and phospholipase D (PLD) activation was detected as a 4-fold increase in [3H]choline in cells prelabeled with...

journal_title：Biochemical and biophysical research communications

authors： Martin TW,Feldman DR,Goldstein KE,Wagner JR

更新日期：1989-11-30 00:00:00

abstract：:Using small interfering RNA (siRNA) to induce sequence specific gene silencing is fast becoming a standard tool in functional genomics. As siRNAs in some cases tolerate mismatches with the mRNA target, knockdown of genes other than the intended target could make results difficult to interpret. In an investigation of 3...

journal_title：Biochemical and biophysical research communications

authors： Snøve O Jr,Holen T

更新日期：2004-06-18 00:00:00

abstract：:We investigated the effect of ziprasidone, a widely used treatment for schizophrenia, on voltage-dependent K+ (Kv) channels of coronary arterial smooth muscle cells using the patch-clamp technique. Ziprasidone dose-dependently inhibited Kv channels with an IC50 value of 0.39 ± 0.06 μM and a Hill coefficient of 0.62 ± ...

journal_title：Biochemical and biophysical research communications

authors： An JR,Seo MS,Jung HS,Heo R,Kang M,Ha KS,Park H,Park WS

更新日期：2020-08-20 00:00:00

abstract：:Expression of thin aggregative fimbriae (Agf) in Salmonella, which is responsible for bacterial cell adhesion to surfaces, aggregation, and formation of biofilms, is regulated by a complex mechanism. In order to identify gene(s) involved in the expression of Agf, the TnphoA transposon was introduced into Salmonella ty...

journal_title：Biochemical and biophysical research communications

authors： Yoo AY,Yu JE,Yoo H,Lee TH,Lee WH,Oh JI,Kang HY

更新日期：2013-01-04 00:00:00

abstract：:Immature secretory granules (ISG's) are sites of segregation of proteins destined for secretion by unregulated pathways from those stored in mature secretory granules in endocrine cells. To determine whether significant soluble protein sorting occurs in ISG's, the secretion of soluble versions of the pancreatic protei...

journal_title：Biochemical and biophysical research communications

authors： Rindler MJ,Colomer V,Jin Y

更新日期：2001-11-16 00:00:00

abstract：:Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. DNA methylation-mediated silenced genes in pancreatic cancer were searched for using the methyl-CpG targeted transcriptional activation (MeTA) method, and LHX6 (LIM homeobox 6), a transcription factor involve...

journal_title：Biochemical and biophysical research communications

authors： Abudurexiti Y,Gu Z,Chakma K,Hata T,Motoi F,Unno M,Horii A,Fukushige S

更新日期：2020-06-04 00:00:00

abstract：:Lon protease has been well studied in many aspects; however, the DNA-binding specificity of Lon in prokaryotes has not been clearly identified. Here we examined the DNA-binding activity of Lon protease alpha-domains from Brevibacillus thermoruber (Bt), Bacillus subtilis (Bs), and Escherichia coli (Ec). MALDI-TOF mass ...

journal_title：Biochemical and biophysical research communications

authors： Lin YC,Lee HC,Wang I,Hsu CH,Liao JH,Lee AY,Chen C,Wu SH

更新日期：2009-10-09 00:00:00

abstract：:We investigated the action of vanadate on protein phosphorylation in microvessels isolated from rat brain. We found that a stimulation of protein phosphorylation from 32P-ATP occurs, in the presence of different concentrations of vanadate, 10(-3) M being the most effective dose. This action was time-dependent, and it ...

journal_title：Biochemical and biophysical research communications

authors： Catalán RE,Martínez AM,Aragonés MD,Díaz G

更新日期：1989-09-15 00:00:00

abstract：:To investigate the biological function of CKII, we have identified proteins that interact with the subunits of CKII using the yeast two-hybrid system. Here we report that SAG, an antioxidant protein containing Ring-H2 finger motif, is a cellular partner associating with the beta subunit of CKII. SAG does not interact ...

journal_title：Biochemical and biophysical research communications

authors： Son MY,Park JW,Kim YS,Kang SW,Marshak DR,Park W,Bae YS

更新日期：1999-10-05 00:00:00

abstract：:Saccharomyces cerevisiae RecQ helicase (Sgs1) combines with DNA topoisomerase III (Top3) and RecQ-mediated genome instability 1 (Rmi1) to form an evolutionarily conserved complex that is required for processing homologous recombination intermediates and restarting collapsed replication forks. It was previously reporte...

journal_title：Biochemical and biophysical research communications

authors： Lai MS,Seki M,Tada S,Enomoto T

更新日期：2012-10-26 00:00:00

abstract：:Fad104 (factor for adipocyte differentiation 104) is a novel gene expressed temporarily in the early stages of adipocyte differentiation. Previously, we showed that fad104 promotes adipocyte differentiation in mouse 3T3-L1 cells and mouse embryonic fibroblasts (MEFs). Furthermore, we reported that implanted wild-type ...

journal_title：Biochemical and biophysical research communications

authors： Kishimoto K,Kato A,Osada S,Nishizuka M,Imagawa M

更新日期：2010-06-25 00:00:00

abstract：:mRNA levels of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-2, were determined during chemical hepatocarcinogenesis and during regeneration of rat liver. In chemical hepatocarcinogenesis, the mRNA levels of MKP-1 were increased in primary hepatomas but decreased in rat ascites hepatomas as compared wit...

journal_title：Biochemical and biophysical research communications

authors： Yokoyama A,Karasaki H,Urushibara N,Nomoto K,Imai Y,Nakamura K,Mizuno Y,Ogawa K,Kikuchi K

更新日期：1997-10-29 00:00:00

abstract：:A clone of vincristine resistant murine erythroleukemia cells V3.17[44], characterized by high sensitivity to terminal erythroid differentiation induced by hexamethylene bisacetamide, secretes into the extracellular medium a protein factor which partially reduces the latent period before commitment and accelerates the...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Salamino F,Passalacqua M,Melloni E,Pontremoli S

更新日期：1990-11-30 00:00:00

abstract：:We have previously reported that TTF-1, a homeodomain-containing transcription factor, regulates circadian rhythm of pituitary adenylate cyclase-activating polypeptide gene expression in the rat hypothalamus. In this study we found that TTF-1 mRNA was specifically expressed in the rat suprachiasmatic nucleus (SCN) and...

journal_title：Biochemical and biophysical research communications

authors： Son YJ,Yun CH,Kim JG,Park JW,Kim JH,Kang SG,Lee BJ

更新日期：2009-03-13 00:00:00

abstract：:Measurement and validation of microarray gene signatures in routine clinical samples is problematic and a rate limiting step in translational research. In order to facilitate measurement of microarray identified gene signatures in routine clinical tissue a novel method combining quantum dot based oligonucleotide in si...

journal_title：Biochemical and biophysical research communications

authors： Tholouli E,MacDermott S,Hoyland J,Yin JL,Byers R

更新日期：2012-08-24 00:00:00

abstract：:An insect antiviral compound was purified from Heliothis virescens larval hemolymph by gel-filtration high pressure liquid chromatography (HPLC) and C-18 reverse-phase HPLC and its structure was determined by mass spectrometry. The antiviral compound is an N-myristoylated-peptide containing six amino acids with calcul...

journal_title：Biochemical and biophysical research communications

authors： Ourth DD

更新日期：2004-07-16 00:00:00

abstract：:The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts...

journal_title：Biochemical and biophysical research communications

authors： Zolk O,Solbach TF,Eschenhagen T,Weidemann A,Fromm MF

更新日期：2008-11-14 00:00:00

abstract：:Extracellular signal-regulated kinase 1 and 2 (ERK1/2) have been implicated as important regulators of metabolic homeostasis. Here we generated a new mouse model with genetic deletion of two ERK1/2 phosphatases, dual specificity phosphatase (DUSP) 6 and 8, to further define the role of ERK1/2 in obesity development. D...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Peters M,Urban N,Knowlton J,Napierala T,Gabrysiak J

更新日期：2020-11-26 00:00:00

abstract：:EGF stimulates gene expression through a variety of signal transduction pathways that include the ras-Erk pathway. We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE. This element binds Sp1 family members and raises the possibility that the ra...

journal_title：Biochemical and biophysical research communications

authors： Merchant JL,Du M,Todisco A

更新日期：1999-01-19 00:00:00

abstract：:Lipocortin I-S100 (calcyclin) heterotetramer exhibited ATPase activity in the presence of dsDNA but not ssDNA. To demonstrate its helicase activity, an 80-mer polynucleotide complementary to the replication origin of M13mp18 was synthesized, and the oligonucleotide, (dC)(20), was ligated to either its 5'- or 3'- end f...

journal_title：Biochemical and biophysical research communications

authors： Hirata A,Hirata F

更新日期：2002-02-22 00:00:00

abstract：:The polycationic nature of biogenic polyamines such as spermine (SPM, 1) and spermidine (SPD, 2) plays an important role in selective binding to polyanionic nucleic acids. These interactions are mediated by electrostatic and hydrogen bonding forces which led to stabilization of DNA duplexes and triplexes. Transformati...

journal_title：Biochemical and biophysical research communications

authors： Pallan PS,Ganesh KN

更新日期：1996-05-15 00:00:00

abstract：:Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3.1.5) were expressed in monkey kidney COS-1 cells and used to study the N- and O-acetylation of a number of carcinogenic amines and their N-hydroxy metabolites. The monomorphic enzyme N-acetylated the aromatic amines, 2-aminofluorene and 4-aminobiph...

journal_title：Biochemical and biophysical research communications

authors： Minchin RF,Reeves PT,Teitel CH,McManus ME,Mojarrabi B,Ilett KF,Kadlubar FF

更新日期：1992-06-30 00:00:00

abstract：:Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin va...

journal_title：Biochemical and biophysical research communications

authors： Nakazato M,Kangawa K,Minamino N,Tawara S,Matsuo H,Araki S

更新日期：1984-07-31 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in patients with PCOS...

journal_title：Biochemical and biophysical research communications

authors： Yu CJ,Liu X,Zhou ZY,Chen XJ,Meng YC,Gu HC,Xu JJ,Ding GL,Liu XM,Sheng JZ,Huang HF

更新日期：2020-02-17 00:00:00