DISC1, PDE4B, and NDE1 at the centrosome and synapse.


:Disrupted-In-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and other major mental illnesses. Its protein binding partners include the Nuclear Distribution Factor E Homologs (NDE1 and NDEL1), LIS1, and phosphodiesterases 4B and 4D (PDE4B and PDE4D). We demonstrate that NDE1, NDEL1 and LIS1, together with their binding partner dynein, associate with DISC1, PDE4B and PDE4D within the cell, and provide evidence that this complex is present at the centrosome. LIS1 and NDEL1 have been previously suggested to be synaptic, and we now demonstrate localisation of DISC1, NDE1, and PDE4B at synapses in cultured neurons. NDE1 is phosphorylated by cAMP-dependant Protein Kinase A (PKA), whose activity is, in turn, regulated by the cAMP hydrolysis activity of phosphodiesterases, including PDE4. We propose that DISC1 acts as an assembly scaffold for all of these proteins and that the NDE1/NDEL1/LIS1/dynein complex is modulated by cAMP levels via PKA and PDE4.


Bradshaw NJ,Ogawa F,Antolin-Fontes B,Chubb JE,Carlyle BC,Christie S,Claessens A,Porteous DJ,Millar JK




Has Abstract


2008-12-26 00:00:00














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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sammar M,Gulbins E,Hilbert K,Lang F,Altevogt P

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Anemüller S,Schmidt CL,Schäfer G,Bill E,Trautwein AX,Teixeira M

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    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Okamoto T,Takahashi S,Nakamura E,Nagaya K,Hayashi T,Fujieda K

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Min DS,Exton JH

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Koyama Y,Suzuki M,Yoshida T

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    authors: Van Antwerpen P,Boudjeltia KZ,Babar S,Legssyer I,Moreau P,Moguilevsky N,Vanhaeverbeek M,Ducobu J,Nève J

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Payen L,Courtois A,Loewert M,Guillouzo A,Fardel O

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jüppner H,Brabant G,Kapteina U,Kirschner M,Klein H,Hesch RD

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Nakajima R,Yamazaki I,Griffin BW

    更新日期:1985-04-16 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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