当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids.

Proteolipid protein from the peripheral nervous system also contains covalently bound fatty acids.

Abstract：

:Proteolipid protein, the major protein component of central nervous system (CNS) myelin, is known to contain approximately 2% by weight of covalently bound fatty acids. Recently, this protein was also found, though at a lower concentration, in the peripheral nervous system (PNS). The present study was undertaken to determine whether PNS proteolipid protein, like its CNS counterpart, was fatty acylated. Myelin PLP and DM-20, the two proteins that constitute the proteolipid protein fraction, were isolated from bovine sciatic nerves by chromatography on a methylated Sephadex G-100 column. The identity of the isolated proteins was determined by (a) SDS-PAGE, (b) Western blot analysis, and (c) amino acid analysis, and fractions containing only PLP and DM-20 were subjected to acid-methanolysis. Gas-liquid chromatography of the released methyl esters revealed the presence of fatty acids (2.9% w/w) distributed as approximately 47% palmitic, 22% stearic, and 19% oleic acid. Similar results were obtained for bovine white matter proteolipid protein when isolated and analyzed in parallel with the peripheral nerve protein. These data unequivocally demonstrate that both PNS and CNS proteolipid protein are equally acylated.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tetzloff SU,Bizzozero OA

doi

10.1006/bbrc.1993.1767

subject

Has Abstract

pub_date

1993-06-30 00:00:00

pages

1304-10

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71767-5

journal_volume

193

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties.

    abstract：:Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). The present study examined the molecular mechanism underlying ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.01.112

    authors： Auger C,Kim JH,Chabert P,Chaabi M,Anselm E,Lanciaux X,Lobstein A,Schini-Kerth VB

    更新日期：2010-02-26 00:00:00

  • Identification of dnaK multigene family in Synechococcus sp. PCC7942.

    abstract：:Three dnaK gene homologs have been cloned and sequenced from cyanobacterium Synechococcus sp. PCC7942 using a set of primers designed from two conserved regions of known dnaK genes. This is the first example of triple genes for dnaK from prokaryotic cells. These three genes were derived from different loci of the chro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1724

    authors： Nimura K,Yoshikawa H,Takahashi H

    更新日期：1994-05-30 00:00:00

  • Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding.

    abstract：:We have used site-directed mutagenesis to investigate the requirement of cysteine residues in the extracellular domains of the human VIP 1 receptor for binding VIP. Cys37, Cys50, Cys63, Cys72, Cys86, Cys105 and Cys122 (N-terminal extracellular domain), Cys208 and Cys215 (second extracellular loop) and Cys288 (third ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1897

    authors： Gaudin P,Couvineau A,Maoret JJ,Rouyer-Fessard C,Laburthe M

    更新日期：1995-06-26 00:00:00

  • Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells.

    abstract：:Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. In cultured bovine aortic endothelial cells (BAEC), we have found that a 130 kDa protein (p130) was rapidly tyrosine phosphorylated within ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8198

    authors： Ochi H,Kume N,Nishi E,Moriwaki H,Masuda M,Fujiwara K,Kita T

    更新日期：1998-02-24 00:00:00

  • Production and secretion of interleukin-1alpha proteins by rat testis.

    abstract：:The present study characterizes constitutively expressed rat testicular interleukin-1alpha (IL-1alpha) proteins. IL-1 bioactivity of crude testis protein was completely neutralized by IL-1alpha antiserum, IL-1 receptor antagonist, and soluble type I IL-1 receptor. Upon non-denaturating gel permeation chromatography, b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02239-8

    authors： Gustafsson K,Sultana T,Zetterström CK,Setchell BP,Siddiqui A,Weber G,Söder O

    更新日期：2002-09-27 00:00:00

  • Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid.

    abstract：:The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0733

    authors： Hun CS,Hasegawa K,Kawabata T,Kato M,Shimokawa T,Kagawa Y

    更新日期：1999-05-27 00:00:00

  • CARMA3 is overexpressed in colon cancer and regulates NF-κB activity and cyclin D1 expression.

    abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.152

    authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

    更新日期：2012-09-07 00:00:00

  • Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder.

    abstract：:Intercellular spaces between adjacent mucosal epithelial cells are sealed by tight junctions (TJs) that prevent the free movement of solutes across the epithelium. Claudins (CLs), a family of 27 integral membrane proteins, are essential components for TJ seals. We previously used a CL-3/-4 binder, the C-terminal fragm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.060

    authors： Matsuhisa K,Kondoh M,Suzuki H,Yagi K

    更新日期：2012-06-29 00:00:00

  • Intracellular calcium levels can regulate Importin-dependent nuclear import.

    abstract：:We previously showed that increased intracellular calcium can modulate Importin (Imp)β1-dependent nuclear import of SRY-related chromatin remodeling proteins. Here we extend this work to show for the first time that high intracellular calcium inhibits Impα/β1- or Impβ1-dependent nuclear protein import generally. The b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.047

    authors： Kaur G,Ly-Huynh JD,Jans DA

    更新日期：2014-07-18 00:00:00

  • Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart.

    abstract：RATIONALE:Islet-1 positive (Islet-1(+)) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta and pulmonary arte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.074

    authors： Weinberger F,Mehrkens D,Starbatty J,Nicol P,Eschenhagen T

    更新日期：2015-01-02 00:00:00

  • Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain.

    abstract：:RING finger (C3HC4-type zinc finger) is a variant zinc finger motif present in a large family of functionally distinct proteins. We describe the cloning and characterization of a novel human transcript RNF38 encoding a new member of the RING finger protein family. The complete mRNA consists of about 6.8 kb widely expr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00584-3

    authors： Eisenberg I,Hochner H,Levi T,Yelin R,Kahan T,Mitrani-Rosenbaum S

    更新日期：2002-06-28 00:00:00

  • LAMP-2 mediates oxidative stress-dependent cell death in Zn2+-treated lung epithelium cells.

    abstract：:Zinc is an essential element for the biological system. However, excessive exogenous Zn2+ would disrupt cellular Zn2+ homeostasis and cause toxicity. In particular, Zinc salts or ZnO nanoparticles exposure could induce respiratory injury. Although previous studies have indicated that organelle damage (including mitoch...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.030

    authors： Qin X,Zhang J,Wang B,Xu G,Zou Z

    更新日期：2017-06-17 00:00:00

  • Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development.

    abstract：:Plants use specialized root outgrowths, termed root hairs, to enhance acquisition of nutrients and water, help secure anchorage, and facilitate interactions with soil microbiome. One of the major regulators of this process is GLABRA2 (GL2), a transcriptional repressor of root hair differentiation. However, regulation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.084

    authors： Wu R,Citovsky V

    更新日期：2017-07-01 00:00:00

  • Protective effects of kenpaullone on cardiomyocytes following H2O2-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3.

    abstract：:A previous study showed that small G protein signaling modulator 3 (SGSM3) was highly correlated with Cx43 in heart functions and that high levels of SGSM3 may induce Cx43 turnover through lysosomal degradation in infarcted rat hearts. Here, we investigated the protective effects of kenpaullone on cardiomyocytes follo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.03.166

    authors： Joo HC,Choi JW,Moon H,Lee CY,Yoo KJ,Kim SW,Hwang KC

    更新日期：2018-05-05 00:00:00

  • Trafficking and surface expression of the glutamate receptor subunit, KA2.

    abstract：:Kainate receptors are a class of ionotropic glutamate receptors that are widely expressed in the mammalian brain, yet little is known about their physiological role or the mechanisms by which they are regulated. Kainate receptors are composed of multiple subunits (GluR5-7; KA1-2), which can combine to form homomeric o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.115

    authors： Hayes DM,Braud S,Hurtado DE,McCallum J,Standley S,Isaac JT,Roche KW

    更新日期：2003-10-10 00:00:00

  • Endogenous parathyroid hormone (PTH) signals through osteoblasts via RANKL during fracture healing to affect osteoclasts.

    abstract：AIM:To investigate the effect of endogenous PTH deficiency on osteoclasts during fracture healing and its mechanism. METHODS:A femoral fracture model was used to determine the role of endogenous PTH in fracture healing. Immunohistochemistry, qPCR, and Western blot were used to determine the potential functions and mec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.177

    authors： Sun P,Wang M,Yin GY

    更新日期：2020-05-14 00:00:00

  • Differential PAX3 functions in normal skin melanocytes and melanoma cells.

    abstract：:The PAX3 transcription factor is the key regulator of melanocyte development during embryogenesis and is also frequently found in melanoma cells. While PAX3 is known to regulate melanocyte differentiation, survival, proliferation and migration during development, it is not clear if its function is maintained in adult ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.053

    authors： Medic S,Rizos H,Ziman M

    更新日期：2011-08-12 00:00:00

  • Distribution of D(5) dopamine receptor mRNA in rat ventromedial hypothalamic nucleus.

    abstract：:Estrogen induces lordosis through, in part, estrogen receptor (ER)-mediated synthesis of progesterone receptors (PR) in the ventromedial nucleus (VMN). In vitro, PR is activated by the neurotransmitter dopamine through D1-like receptors (1). In vivo, lordosis is induced by dopamine, an effect mediated in part by PR an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1851

    authors： Zhou D,Apostolakis EM,O'Malley BW

    更新日期：1999-12-20 00:00:00

  • TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6.

    abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02939-x

    authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

    更新日期：2003-01-24 00:00:00

  • G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.

    abstract：:The addition of the chemotactic factor fMet-Leu-Phe to cell homogenates causes a decrease in the pertussis toxin catalyzed ADP-ribosylation of a 41 kDa protein. The fMet-Leu-Phe induced decrease is not abolished in homogenates prepared from phorbol 12-myristate 13-acetate treated neutrophils. This decreased ribosylati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91380-5

    authors： Matsumoto T,Molski TF,Kanaho Y,Becker EL,Sha'afi RI

    更新日期：1987-03-13 00:00:00

  • Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.

    abstract：:Cellular functions induced by cytokine interleukin (IL)-4 and IL-4 signaling through signal transducer and activator of transcription (Stat)6 typify a Th2-type immune response. We investigated the inhibitor effect of the NFkappaB blocker parthenolide in the late-phase, Th2-type immune response. Parthenolide blocked by...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6754

    authors： Schnyder B,Schnyder-Candrian S,Panski A,Bömmel H,Heim M,Duschl A,Moser R

    更新日期：2002-04-12 00:00:00

  • Blind source separation methods for deconvolution of complex signals in cancer biology.

    abstract：:Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in molecular biology. In this short review, we present the common idea behind the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2012.12.043

    authors： Zinovyev A,Kairov U,Karpenyuk T,Ramanculov E

    更新日期：2013-01-18 00:00:00

  • An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy.

    abstract：:Immunoglobulin A (IgA) nephropathy is an important cause of end-stage kidney disease (ESKD). Tubulointerstitial inflammation and subsequent fibrosis appear to be a major contributor of the disease progression to ESKD; however, the underlying mechanism is poorly understood. Herein, we report that a unique feature of CY...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.119

    authors： Cui TG,Ichikawa T,Yang M,Dong X,Li J,Cui T

    更新日期：2009-12-11 00:00:00

  • Physiological validation of photochemical reflectance index (PRI) as a photosynthetic parameter using Arabidopsis thaliana mutants.

    abstract：:Non-photochemical quenching (NPQ) is the most important photoprotective system in higher plants. NPQ can be divided into several steps according to the timescale of relaxation of chlorophyll fluorescence after reaching a steady state (i.e., the fast phase, qE; middle phase, qZ or qT; and slow phase, qI). The dissipati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.02.192

    authors： Kohzuma K,Hikosaka K

    更新日期：2018-03-25 00:00:00

  • A unique EF-hand motif in mnemiopsin photoprotein from Mnemiopsis leidyi: implication for its low calcium sensitivity.

    abstract：:Up to now, all reported Ca(2+)-regulated photoproteins, except for mnemiopsin, have been cloned and expressed in Escherichia coli. In this study, the cDNA for an isotype of mnemiopsin, from the ctenophore Mnemiopsis leidyi, has been cloned, sequenced, and functionally expressed. The full length cDNA encoding mnemiopsi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.08.022

    authors： Jafarian V,Sariri R,Hosseinkhani S,Aghamaali MR,Sajedi RH,Taghdir M,Hassannia S

    更新日期：2011-09-23 00:00:00

  • Functional role for glycosylated subtypes of rat endothelin receptors.

    abstract：:Glycosylation of endothelin (ET) receptors was found to occur in rat cerebellar and atrial membranes. Specifically, we investigated whether the ETA and ETB receptor subtypes differed in their sensitivity to deglycosylation treatment and whether the two affinity states (nanomolar and picomolar) observed in each recepto...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8646

    authors： Shraga-Levine Z,Sokolovsky M

    更新日期：1998-05-19 00:00:00

  • Specific interaction of pRB with a rat genomic DNA fragment, REC11.

    abstract：:The retinoblastoma gene product (pRB) has been known to contain a sequence-nonspecific DNA binding activity. It is unknown whether pRB can recognize and bind to specific DNA sequences. We have recently identified a rat genomic DNA fragment, termed REC11, which can interact with rat Cdc37-related protein (RCdc37). In t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1339

    authors： Ozaki T,Sakiyama S

    更新日期：1996-09-04 00:00:00

  • Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica.

    abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.136

    authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

    更新日期：2017-08-26 00:00:00

  • Promoter analysis and chromosomal mapping of human EBAG9 gene.

    abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2920

    authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

    更新日期：2000-07-05 00:00:00

  • Diphtheria toxin:receptor interaction: association, dissociation, and effect of pH.

    abstract：:Diphtheria toxin (DT) binds to a specific heparin-binding epidermal growth factor-like growth factor (HB-EGF) precursor that is expressed in DT-sensitive cells. DT binds to the cell-surface HB-EGF precursor with an apparent dissociation constant (KD) of approximately 1 x 10(-8) - 10(-9) M at 4 degreesC, a temperature ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8953

    authors： Brooke JS,Cha JH,Eidels L

    更新日期：1998-07-20 00:00:00