当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Intracellular calcium levels can regulate Importin-dependent nuclear import.

Intracellular calcium levels can regulate Importin-dependent nuclear import.

Abstract：

:We previously showed that increased intracellular calcium can modulate Importin (Imp)β1-dependent nuclear import of SRY-related chromatin remodeling proteins. Here we extend this work to show for the first time that high intracellular calcium inhibits Impα/β1- or Impβ1-dependent nuclear protein import generally. The basis of this relates to the mislocalisation of the transport factors Impβ1 and Ran, which show significantly higher nuclear localization in contrast to various other factors, and RCC1, which shows altered subnuclear localisation. The results here establish for the first time that intracellular calcium modulates conventional nuclear import through direct effects on the nuclear transport machinery.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kaur G,Ly-Huynh JD,Jans DA

doi

10.1016/j.bbrc.2014.06.047

subject

Has Abstract

pub_date

2014-07-18 00:00:00

pages

812-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01121-8

journal_volume

450

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity.

    abstract：:FIP-3 (NEMO/IKKgamma) is an essential modulator of the activity of NF-kappaB by mechanisms that include alterations in the phosphorylation, ubiquination, and degradation of IkappaBalpha. The multiple protein-protein interactions of FIP-3 (NEMO/IKKgamma) in a high molecular weight IKK complex indicated that this protei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5197

    authors： Tarassishin L,Horwitz MS

    更新日期：2001-07-13 00:00:00

  • C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.

    abstract：:Two types of natriuretic peptide, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), very similar to each other in structure and in pharmacological effect, are known to be present in mammalian heart and brain. In our present survey for unidentified peptides in porcine brain extracts, we found a new ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92401-k

    authors： Sudoh T,Minamino N,Kangawa K,Matsuo H

    更新日期：1990-04-30 00:00:00

  • Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.

    abstract：:Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.098

    authors： Jung Y,Kim JC,Park NJ,Bong SK,Lee S,Jegal H,Jin LT,Kim SM,Kim YK,Kim SN

    更新日期：2018-02-05 00:00:00

  • The ferrous-oxy complex of human aromatase.

    abstract：:In this communication, we document the self-assembly of heterologously expressed truncated human aromatase (CYP19) into nanometer scale phospholipids bilayers (Nanodiscs). The resulting P450 CYP19 preparation is stable and can tightly associate with the substrate androstenedione to form a nearly complete high-spin fer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.011

    authors： Grinkova YV,Denisov IG,Waterman MR,Arase M,Kagawa N,Sligar SG

    更新日期：2008-07-25 00:00:00

  • Engagement of spectrin and actin in capping of FcgammaRII revealed by studies on permeabilized U937 cells.

    abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0769

    authors： Kwiatkowska K,Sobota A

    更新日期：1999-06-07 00:00:00

  • Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats.

    abstract：:Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.100

    authors： Lim W,Bae H,Sohn JY,Jeong W,Kim SH,Song G

    更新日期：2015-01-02 00:00:00

  • Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5.

    abstract：:Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect. Initially we found that triglyceride turnover was faster in hAPOA5 transgenic mice compared to controls, and this strongly correlated w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.003

    authors： Fruchart-Najib J,Baugé E,Niculescu LS,Pham T,Thomas B,Rommens C,Majd Z,Brewer B,Pennacchio LA,Fruchart JC

    更新日期：2004-06-25 00:00:00

  • The effects of various growth factors on endothelial cell survival in vitro.

    abstract：:The effects of various growth factors on endothelial cell survival in vitro were studied. Using rat heart endothelial cells, the cell survival curves were obtained; the cells were cultured until confluent, the medium was changed to serum-free medium with or without growth factors, and the cells were counted after 3, 6...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90774-2

    authors： Etoh T,Takehara K,Igarashi A,Ishibashi Y

    更新日期：1989-08-15 00:00:00

  • Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase.

    abstract：:Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 microM with 4-h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8845

    authors： He Q,Khanna P,Srivastava S,van Kuijk FJ,Ansari NH

    更新日期：1998-06-29 00:00:00

  • Do rat hepatic microsomes contain multiple NADPH-supported fatty acid chain elongation pathways or a single pathway?

    abstract：:[2-14C]-trans-2-hexadecenoyl CoA (16:1) and [2-14C]-trans-2-cis-8,11,14-eicosatetraenoyl CoA (20:4) were chemically synthesized and employed as competitive substrates for the liver microsomal trans-2-enoyl CoA reductase component of the fatty acid chain elongation system. Both 7.5 microM and 15 microM 20:4 competitive...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91059-4

    authors： Nagi MN,Cook L,Prasad MR,Cinti DL

    更新日期：1986-10-15 00:00:00

  • Novel peptide inhibitor (SPAI) of Na+, K+-ATPase from porcine intestine.

    abstract：:Three unique inhibitors (SPAI-1, -+2, and -3) were first purified from porcine duodenal extract based on the Na+, K+-ATPase inhibitory activity. These peptide inhibitors had four disulfide bridges in common. The sequencing results of their S-carboxymethyl derivatives, lysilendopeptidase fragments, and chymotryptic pep...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91747-6

    authors： Araki K,Kuroki J,Ito O,Kuwada M,Tachibana S

    更新日期：1989-10-16 00:00:00

  • Identification of a novel stress activated kinase in kidney and heart.

    abstract：:We have previously described the patterns of stress kinase activation in rat kidney and heart in response to ischemia/reperfusion (Yin et al., 1997, J. Biol. Chem. 272, 19943-19950). During the course of these studies, we observed the activation of a novel kinase capable of phosphorylating c-Jun on serines 63 and 73. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9365

    authors： De Silva H,Cioffi C,Yin T,Sandhu G,Webb RL,Whelan J

    更新日期：1998-09-29 00:00:00

  • Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder.

    abstract：:Intercellular spaces between adjacent mucosal epithelial cells are sealed by tight junctions (TJs) that prevent the free movement of solutes across the epithelium. Claudins (CLs), a family of 27 integral membrane proteins, are essential components for TJ seals. We previously used a CL-3/-4 binder, the C-terminal fragm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.060

    authors： Matsuhisa K,Kondoh M,Suzuki H,Yagi K

    更新日期：2012-06-29 00:00:00

  • Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions.

    abstract：:Metallothionein (MT) is effective in the prevention of diabetic cardiomyopathy, and hypoxia-inducible factor-1 (HIF-1) is known to control vascular endothelial growth factor (VEGF) gene expression and regulate angiogenesis in diabetic hearts. We examined whether or not MT affects HIF-1 activity in the heart of diabeti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.057

    authors： Feng W,Wang Y,Cai L,Kang YJ

    更新日期：2007-08-17 00:00:00

  • 2'-O-methyl-1-methyl adenosine: a new modified nucleoside in ragi (Eleusine coracana) tRNA.

    abstract：:A new modified nucleoside 2'-O-methyl-l-methyl adenosine has been found to be present in the tRNA of Eleusine coracana ( ragi ) seedlings. The sequence of the dinucleotide of which this modified nucleoside is a part suggests its presence in phenylalanine-tRNA. The structural implications of the presence of this new mo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90713-7

    authors： Raviprakash KS,Cherayil JD

    更新日期：1984-05-31 00:00:00

  • Escherichia coli outer membrane protein A adheres to human brain microvascular endothelial cells.

    abstract：:Escherichia coli K1 is the most common gram-negative bacterium causing neonatal meningitis. The outer membrane protein A (OmpA) assembles a beta-barrel structure having four surface-exposed loops in E. coli outer membrane. OmpA of meningitis-causing E. coli K1 is shown to contribute to invasion of the human brain micr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.097

    authors： Shin S,Lu G,Cai M,Kim KS

    更新日期：2005-05-20 00:00:00

  • CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.

    abstract：:CHFR has been implicated as a tumor suppressor in a multitude of cancers. It was originally identified as a major component of the antephase checkpoint. Recently, CHFR was reported to interact with MAD2, an important component of the spindle assembly checkpoint, where CHFR knockdown resulted in mislocalization of MAD2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.143

    authors： Keller JA,Petty EM

    更新日期：2011-06-10 00:00:00

  • A phytoene desaturase homolog gene from the methanogenic archaeon Methanosarcina acetivorans is responsible for hydroxyarchaeol biosynthesis.

    abstract：:Hydroxyarchaeols are the typical core structures of archaeal membrane lipids uniquely produced by a limited number of methanogenic lineages, which are mainly classified in orders Methanosarcinales and Methanococcales. However, the biosynthetic machinery that is used for the biosynthesis of hydroxyarcheol core lipids h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.09.001

    authors： Mori T,Isobe K,Ogawa T,Yoshimura T,Hemmi H

    更新日期：2015-10-16 00:00:00

  • Multi-frequency EPR evidence for a binuclear CuA center in cytochrome c oxidase: studies with a 63Cu- and 65Cu-enriched, soluble domain of the cytochrome ba3 subunit II from Thermus thermophilus.

    abstract：:We have recorded multi-frequency EPR spectra of 63Cu- and 65Cu-labeled, water-soluble CuA-protein from the cytochrome ba3 of T. thermophilus. The spectrum taken at the highest frequency (34.03 GHz) shows no hyperfine structure and is nominally axial with apparent gz approximately 2.18 and gxy approximately 2.00. The s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1938

    authors： Fee JA,Sanders D,Slutter CE,Doan PE,Aasa R,Karpefors M,Vänngård T

    更新日期：1995-07-06 00:00:00

  • Tumor necrosis factor upregulates interleukin-4 receptors on murine sarcoma cells.

    abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2636

    authors： Puri RK,Leland P

    更新日期：1993-12-30 00:00:00

  • Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes.

    abstract：:Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.051

    authors： Kang B,Kim Y,Park TJ,Kang HY

    更新日期：2020-03-19 00:00:00

  • On the physiological role of neurocuprein: aponeurocuprein is an inhibitor of dopamine beta-monooxygenase.

    abstract：:The apoform of neurocuprein, the copper protein from brain and chromaffin granules, was found to be a potent inhibitor of the hydroxylating activity of dopamine beta-monooxygenase, whereas the holoform of neurocuprein has no effect on the activity of the enzyme. The inhibiting capacity of neurocuprein may be due to th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90238-x

    authors： Markossian KA,Paitian NA,Mikaelyan MV,Nalbandyan RM

    更新日期：1986-07-16 00:00:00

  • Torsion of the central pair microtubules in eukaryotic flagella due to bending-driven lateral buckling.

    abstract：:Inspired by recent interest in torsion of the central pair microtubules in eukaryotic flagella, a novel thin-walled elastic beam model is suggested to study critical condition under which uniform bending of a flagellum will cause lateral/torsional buckling of the central pair. The model is directed to the central pair...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.019

    authors： Li C,Ru CQ,Mioduchowski A

    更新日期：2006-12-08 00:00:00

  • Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains.

    abstract：:We describe here two human VIP receptor cDNA clones isolated from a jejunal epithelial cell cDNA library. The hIVR8 cDNA encodes a human VIP receptor consisting of 460 amino acids and has seven putative transmembrane domains like other G protein-coupled receptors. When expressed in COS-7 cells, hIVR8 conferred specifi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1517

    authors： Couvineau A,Rouyer-Fessard C,Darmoul D,Maoret JJ,Carrero I,Ogier-Denis E,Laburthe M

    更新日期：1994-04-29 00:00:00

  • Long intergenic non-coding RNA 668 regulates VEGFA signaling through inhibition of miR-297 in oral squamous cell carcinoma.

    abstract：:Recently, long noncoding RNAs (lncRNAs) have been reported to have crucial regulatory efficiency in human cancer biology. Long intergenic non-coding RNA 668 (LINC00668) was regarded as an oncogene in multiple cancers. However, the underlying molecular mechanism of LINC00668 in oral squamous cell carcinoma (OSCC) has n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.155

    authors： Zhang CZ

    更新日期：2017-08-05 00:00:00

  • Calcium-dependent activation of glycogen phosphorylase in rat pheochromocytoma PC12 cells by nerve growth factor.

    abstract：:Glycogen phosphorylase in PC12 cells exists in two forms analogous to those found in brain and muscle. The active phosphorylated form of the enzyme, phosphorylase-a, represents about 20-30% of total glycogen phosphorylase in these cells. Incubation of PC12 cells with 100 ng 7S nerve growth factor/ml increased phosphor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80583-6

    authors： Davis LH,Kauffman FC

    更新日期：1986-07-31 00:00:00

  • Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.

    abstract：:FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.119

    authors： Qian Y,Xia S,Feng Z

    更新日期：2017-01-29 00:00:00

  • Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria.

    abstract：:The adenine nucleotide translocase (ANT), besides transferring ATP from the mitochondrial matrix to the rest of the cell, has also been proposed to be involved in mitochondrial permeability transition (MPT), and accordingly in mitochondrial Ca2+ homeostasis. In order to assess the role of ANT in Ca2+ signal transmissi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.072

    authors： Wieckowski MR,Szabadkai G,Wasilewski M,Pinton P,Duszyński J,Rizzuto R

    更新日期：2006-09-22 00:00:00

  • Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer.

    abstract：:Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. DNA methylation-mediated silenced genes in pancreatic cancer were searched for using the methyl-CpG targeted transcriptional activation (MeTA) method, and LHX6 (LIM homeobox 6), a transcription factor involve...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.03.120

    authors： Abudurexiti Y,Gu Z,Chakma K,Hata T,Motoi F,Unno M,Horii A,Fukushige S

    更新日期：2020-06-04 00:00:00

  • Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells.

    abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90926-4

    authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

    更新日期：1984-10-15 00:00:00