Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains.

abstract：:Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV is classified into ...

journal_title：Biochemical and biophysical research communications

authors： Takagi A,Ikeda Y,Kobayashi K,Kobayashi K,Ikeda Y,Kozawa J,Miyauchi H,Li M,Hashimoto C,Hara Y,Yamaguchi S,Suzuki A,Toda T,Nagasaka H,Hirano KI

更新日期：2018-01-01 00:00:00

abstract：:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated ...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

更新日期：1997-09-08 00:00:00

abstract：:Until now, voltage-gated Ca(2+) channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca(2+) channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in i...

journal_title：Biochemical and biophysical research communications

authors： Durell SR,Guy HR

更新日期：2001-03-02 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) have been considered to be desirable targets for metabolic syndrome, even though their specific agonists have several side effects including body weight gain, edema and tissue failure. Previously, we have reported in vitro effects of Sargassum yezoense (SY) and its i...

journal_title：Biochemical and biophysical research communications

authors： Kim SN,Lee W,Bae GU,Kim YK

更新日期：2012-08-10 00:00:00

abstract：:Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKε plays a similar metabolic role. IKKε(-/-) mice had reduced body weight, leptin levels, as well as high...

journal_title：Biochemical and biophysical research communications

authors： Scheja L,Heese B,Seedorf K

更新日期：2011-04-08 00:00:00

abstract：:Antibody against actin isolated from a human EBV-transformed lymphoblastoid B-cell line exerted an inhibitory effect on in vitro IgM secretion by a different lymphoblastoid B-cell line, LA350. This effect was dose dependent showing from 24-40% inhibition at a dilution of 1:100 and 68-80% inhibition at a dilution of 1:...

journal_title：Biochemical and biophysical research communications

authors： Rosenblatt HM,Green CG,McClure JE,Shearer WT

更新日期：1986-10-15 00:00:00

abstract：:RegIIIβ and RegIIIγ are antimicrobial peptides expressed in intestinal epithelial cells. Expression of these peptides is reportedly decreased by high-fat diet (HFD) and increased by indigestible oligosaccharides in mice. Clearly, these dietary regimens change the structure of intestinal microbiota. We employed an inte...

journal_title：Biochemical and biophysical research communications

authors： Udomsopagit T,Miwa A,Seki M,Shimbori E,Kadota Y,Tochio T,Sonoyama K

更新日期：2020-08-13 00:00:00

abstract：:The effects of intracisternal (ic) injection of recombinant interleukin-1 beta (IL-1) on absolute ethanol-induced gastric necrotic lesions were studied in conscious rats. IL-1 given ic inhibited ethanol-induced gastric lesions. The cytoprotective effect was dose dependent (ED175 ng/rat), long lasting with a maximal ac...

journal_title：Biochemical and biophysical research communications

authors： Robert A,Saperas E,Zhang WR,Olafsson AS,Lancaster C,Tracey DE,Chosay JG,Taché Y

更新日期：1991-02-14 00:00:00

abstract：:Tri-iodothyronine stimulates neurotensin secretion from rat hypothalami in vitro. Propylthiouracil treatment of rats is associated with a decrease in anterior pituitary neurotensin content, an increase in hypothalamic content and an impaired release of peptide from hypothalami in vitro. In addition neurotensin has a d...

journal_title：Biochemical and biophysical research communications

authors： Sheppard MC,Askew RD,Shennan KI,Franks S,Ramsden DB

更新日期：1983-05-31 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:The muscarinic acetylcholine receptor was solubilized, in a sensitive form for GTP and Na+, from bovine cerebral cortex using a zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate. The solubilized muscarinic receptor displayed characteristics as follows: (1) high affinity to nanomolar co...

journal_title：Biochemical and biophysical research communications

authors： Kuno T,Shirakawa O,Tanaka C

更新日期：1983-05-16 00:00:00

abstract：:Four IgE-binding epitopes have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum). They mainly correspond to electropositively charged regions protruding on the molecular surface of the modeled apple (Mal d 3), apr...

journal_title：Biochemical and biophysical research communications

authors： Borges JP,Barre A,Culerrier R,Granier C,Didier A,Rougé P

更新日期：2008-01-25 00:00:00

abstract：:A biotin-polyethylene glycol (PEG)-epidermal growth factor (EGF) conjugate was immobilized onto the surface of avidin-modified adenovirus (ADV-Avi) via biotin-avidin interaction to deliver ADV specifically to EGF receptor over-expressing cancer cells. ADV-Avi/biotin-PEG-EGF complexes showed greatly enhanced intracellu...

journal_title：Biochemical and biophysical research communications

authors： Park JW,Mok H,Park TG

更新日期：2008-02-15 00:00:00

abstract：:PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and...

journal_title：Biochemical and biophysical research communications

authors： Kozlov G,Perreault A,Schrag JD,Park M,Cygler M,Gehring K,Ekiel I

更新日期：2004-08-13 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently mutated in CRC, and KRAS mutations promote cell motility, growth, and survival. We previously revealed that the expression of phospholipase C (PLC) δ1, one of the most...

journal_title：Biochemical and biophysical research communications

authors： Shimozawa M,Anzai S,Satow R,Fukami K

更新日期：2017-07-08 00:00:00

abstract：:Two-types of high molecular mass proteases have been purified from sea urchin sperm using DEAE-Sephacel, hydroxylapatite and Superdex 200 column chromatography. Both proteases showed similar hydrolyzing activities toward synthetic peptides, but they differed in the molecular mass and peptide composition. One was proba...

journal_title：Biochemical and biophysical research communications

authors： Inaba K,Akazome Y,Morisawa M

更新日期：1992-01-31 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and interleukin-6 (IL-6), both known to be able to open the blood-brain barrier (BBB), downregulated plasma membrane-associated tyrosine phosphatase activity in primary porcine brain endothelial cells (PBEC). In contrast, transforming growth factor beta (TGF-beta) upregulated PTP activ...

journal_title：Biochemical and biophysical research communications

authors： Gloor SM,Weber A,Adachi N,Frei K

更新日期：1997-10-29 00:00:00

abstract：:GV1001, a synthetic peptide derived from human telomerase, has a range of diverse biological activities, including an antioxidant function. Here, we investigated the role of GV1001 in hepatitis C virus (HCV)-infected Huh7.5 (JFH-1) cells. We showed that GV1001 inhibited the production of ROS with decreased MAP kinase ...

journal_title：Biochemical and biophysical research communications

authors： Lee SA,Kim J,Sim J,Kim SG,Kook YH,Park CG,Kim HR,Kim BJ

更新日期：2016-02-26 00:00:00

abstract：:Progesterone (P4) and progesterone receptor (PR) have important functions in uterine environment. In previous studies, using high density DNA microarray analysis, we identified low density lipoprotein receptor-related protein 2 (Lrp2) is one of the genes upregulated by P4 and PR. In present studies, we examined the ex...

journal_title：Biochemical and biophysical research communications

authors： Oh SJ,Kim TH,Lim JM,Jeong JW

更新日期：2013-11-08 00:00:00

abstract：:Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+ protect against inactivation and modification, in agreement with the study on E. coli dUTPase (Vertessy et al. ...

journal_title：Biochemical and biophysical research communications

authors： Vertessy BG,Persson R,Rosengren AM,Zeppezauer M,Nyman PO

更新日期：1996-02-15 00:00:00

abstract：:Oxygen resistant N2-fixing Escherichia coli, which can grow at a high oxygen concentration in a nitrogen-free medium, were produced by several times of cultivation under a condition of 0.03% oxygen. Six isolated resistant strains could grow at an oxygen concentration ten times that of the parent strain. The nif-genes ...

journal_title：Biochemical and biophysical research communications

authors： Iwahashi H,Someya J

更新日期：1990-04-16 00:00:00

abstract：:The morphology and function of Leydig cells are changed during the development, mature and senility of Leydig cells along the life span of males. This study was to observe the growth morphology of adult mouse Leydig cells in culture, aiming to provide a reference for furthermore understanding of the biological functio...

journal_title：Biochemical and biophysical research communications

authors： Wang JQ,Cao WG

更新日期：2016-01-22 00:00:00

abstract：:Using atomic force microscopy (AFM), we find that RecA-single-stranded DNA (RecA-ssDNA) filaments, in the presence of single-stranded DNA-binding (SSB) protein, organize into left-handed bundles, which differ from the previously reported disordered aggregates formed when SSB is excluded from the reaction. In addition,...

journal_title：Biochemical and biophysical research communications

authors： Shi WX,Larson RG

更新日期：2007-06-08 00:00:00

abstract：:The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S3 cells were more sensitive than OMCT cells in cell viability and H2O2 production during cisplatin treatment. The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment wi...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumishita Y,Onda T,Okada K,Takeda M,Endou H,Futaki S,Niwa M

更新日期：1998-01-14 00:00:00

abstract：:Rabbit brain synaptosomes bind the 1,4-dihydropyridine derivative (+)[3H]-PN 200-110 with an equilibrium dissociation constant of 0.04 nM and a maximal binding capacity of 400 fmol/mg of protein. Using polyclonal antibodies raised against the different components of the skeletal muscle 1,4-dihydropyridine receptor, we...

journal_title：Biochemical and biophysical research communications

authors： Schmid A,Barhanin J,Mourre C,Coppola T,Borsotto M,Lazdunski M

更新日期：1986-09-30 00:00:00

abstract：:Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is ubiquitylated and degraded by the proteasome pathway in human cells. Firstly, the fate of Cdc45 protein after induction of terminal diff...

journal_title：Biochemical and biophysical research communications

authors： Pollok S,Grosse F

更新日期：2007-11-03 00:00:00

abstract：:The treatment of human platelets with the dibutyryl cyclic AMP (dbcAMP) revealed the presence of a 250 kDa protein which enhanced its GTP-binding activity. This protein was purified from platelet membranes by successive chromatographies on DEAE-cellulose, Ultrogel AcA34, Mono Q, HCA-hydroxyapatite, and TSK-3000SW colu...

journal_title：Biochemical and biophysical research communications

authors： Yada Y,Okano Y,Nozawa Y

更新日期：1990-10-15 00:00:00

abstract：:Acetyl-CoA carboxylases (ACCs) have been highlighted as therapeutic targets for obesity and diabetes, as they play crucial roles in fatty acid metabolism. ACC activity is regulated through the short-term mechanism of inactivation by reversible phosphorylation. Here, we report the crystal structures of the biotin carbo...

journal_title：Biochemical and biophysical research communications

authors： Cho YS,Lee JI,Shin D,Kim HT,Jung HY,Lee TG,Kang LW,Ahn YJ,Cho HS,Heo YS

更新日期：2010-01-01 00:00:00

abstract：:The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane seg...

journal_title：Biochemical and biophysical research communications

authors： Galindo BE,de la Vega-Beltrán JL,Labarca P,Vacquier VD,Darszon A

更新日期：2007-03-16 00:00:00

abstract：:A clone of vincristine resistant murine erythroleukemia cells V3.17[44], characterized by high sensitivity to terminal erythroid differentiation induced by hexamethylene bisacetamide, secretes into the extracellular medium a protein factor which partially reduces the latent period before commitment and accelerates the...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Salamino F,Passalacqua M,Melloni E,Pontremoli S

更新日期：1990-11-30 00:00:00