Neurotensin regulation of TSH secretion in the rat.

abstract：:A new enzyme, tetrahydromethanopterin methyltransferase, which catalyzes the transfer of methyl groups from methyl-tetrahydromethanopterin to 2-mercaptoethane-sulfonate, has been found in the methane synthesizing complex of Methanobacterium thermoautotrophicum. The enzyme is oxygen sensitive and has a well defined pH ...

journal_title：Biochemical and biophysical research communications

authors： Sauer FD

更新日期：1986-04-29 00:00:00

abstract：:Addition of 5% hexadecane to the diet of rats increased fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from 14 to 39% of an LD50 dose (60 micrograms/kg) during 10 days after dosing. This enhanced elimination did not result in reduced toxicity. On the contrary, the treatment has increased mortality from ...

journal_title：Biochemical and biophysical research communications

authors： Rozman K

更新日期：1984-12-28 00:00:00

abstract：:FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK...

journal_title：Biochemical and biophysical research communications

authors： Qian Y,Xia S,Feng Z

更新日期：2017-01-29 00:00:00

abstract：:Preproenkephalin A messenger RNA was detected in hamster heart by Northern blot analysis using a human preproenkephalin A cDNA probe. Ventricular levels of this messenger were one order of magnitude lower than atrial levels, which were equivalent to brain levels. Furthermore, in the heart of cardiomyopathic hamsters, ...

journal_title：Biochemical and biophysical research communications

authors： Ouellette M,Brakier-Gingras L

更新日期：1988-08-30 00:00:00

abstract：:Cultured bovine pulmonary artery endothelial cells contain a second peptidyl dipeptidase, distinct from angiotensin-converting enzyme, present in an inactive form associated with a non-dialyzable inhibitor. Partial purification by glycine affinity chromatography separates enzyme from inhibitor to yield a preparation w...

journal_title：Biochemical and biophysical research communications

authors： Lanzillo JJ,Dasarathy Y,Stevens J,Fanburg BL

更新日期：1986-01-29 00:00:00

abstract：:Recently, increasing evidences demonstrate that circular RNAs (circRNAs) exert very important functions in the progression of human cancers. However, the functions and molecular mechanism of circ_0067934 in hepatocellular carcinoma (HCC) are largely unknown. In the present study, we found that the expression of circ_0...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Lu G,Luo Z,Gui F,Wu J,Zhang D,Ni Y

更新日期：2018-03-04 00:00:00

abstract：:Receptor-mediated responses to prostaglandins E1 and E2 are shown by electrophysiological methods in follicle-enclosed oocytes of Xenopus laevis. In voltage-clamped oocytes, prostaglandins E1 and E2 elicited an outward hyperpolarizing current. This outward membrane current was caused by an increase in K+ conductance. ...

journal_title：Biochemical and biophysical research communications

authors： Mori K,Oka S,Tani A,Ito S,Watanabe Y

更新日期：1989-08-15 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:A monoclonal antibody (mAb) 25B1 directed against fetal bovine-serum acetylcholinesterase (FBS AChE) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (A beta) into Alzheimerś fibrils. This mAb binds to the peripheral anionic site of the enzyme and allostericall...

journal_title：Biochemical and biophysical research communications

authors： Reyes AE,Perez DR,Alvarez A,Garrido J,Gentry MK,Doctor BP,Inestrosa NC

更新日期：1997-03-27 00:00:00

abstract：:The codon-reading properties of wobble-position variants of the unmodified form of Escherichia coli tRNASer1 (the UGA anticodon) were measured in a cell-free translation system. Two variants, with the AGA and CGA anticodons, each exclusively read a single codon, UCU and UCG, respectively. The only case of efficient wo...

journal_title：Biochemical and biophysical research communications

authors： Takai K,Takaku H,Yokoyama S

更新日期：1999-04-21 00:00:00

abstract：:The 3'UTR of eukaryotic mRNA is an important regulation region, on which many trans factors act. In recent years, a series of 3'UTRs were shown to have tumor suppressor function, including the 3'UTR of the human nuclear factor for interleukin-6 (NF-IL6 3'UTR). To understand molecular basis for this function, we have t...

journal_title：Biochemical and biophysical research communications

authors： He YZ,Liu DG

更新日期：2000-09-16 00:00:00

abstract：:The gene in the oligodendrocyte lineage (golli) encodes a number of proteins essential for myelination, comprising Golli and classic isoforms that are expressed in a developmentally-regulated manner. The Golli-interacting-protein (GIP) was previously discovered in a search for potential interacting partners of the Gol...

journal_title：Biochemical and biophysical research communications

authors： Jaramillo-Tatis S,Vassall KA,Bamm VV,Harauz G

更新日期：2014-05-16 00:00:00

abstract：:In order to develop improved synthetic gene transfer vectors, we have synthesized bifunctional peptides composed of a DNA binding peptide (P2) and ligand peptides selected by the phage display technique on tracheal epithelial cells. We have evaluated the capacity of these peptides to enhance the gene transfer efficien...

journal_title：Biochemical and biophysical research communications

authors： Vaysse L,Guillaume C,Burgelin I,Gorry P,Férec C,Arveiler B

更新日期：2002-02-08 00:00:00

abstract：:Zinc-finger antiviral protein (ZAP) is a recently isolated host antiviral factor that inhibits the replication of many viruses such as Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral mRNA in the cytoplasm. ZAP comprises four CCCH zinc-finger motifs, the second and fo...

journal_title：Biochemical and biophysical research communications

authors： Jeong MS,Kim EJ,Jang SB

更新日期：2010-06-04 00:00:00

abstract：:N-(p-amylcinnamoyl)anthranilic acid (ACA), a phospholipase A(2) (PLA(2)) inhibitor, is structurally-related to non-steroidal anti-inflammatory drugs (NSAIDs) of the fenamate group and may also modulate various ion channels. We used the whole-cell, patch-clamp technique at room temperature to investigate the effects of...

journal_title：Biochemical and biophysical research communications

authors： Gwanyanya A,Macianskiene R,Bito V,Sipido KR,Vereecke J,Mubagwa K

更新日期：2010-11-19 00:00:00

abstract：:A hammerhead ribozyme directed against murine TNFalpha (mTNFalpha) mRNA has been constructed. In vitro studies showed that this ribozyme was released from the parent molecule by flanking cis-acting hammerhead and hairpin ribozymes. This same anti-mTNFalpha ribozyme specifically cleaved both synthetically derived subst...

journal_title：Biochemical and biophysical research communications

authors： MacKay SL,Tannahill CL,Auffenberg T,Ksontini R,Copeland EM 3rd,Moldawer LL

更新日期：1999-07-05 00:00:00

abstract：INTRODUCTION:Radiotherapy is an equivalent alternative or complement to radical prostatectomy, with high therapeutic efficacy. High risk patients, however, experience high relapse rates, so that research on radio-sensitization is the most evident route to improve curability of this common disease. MATERIALS AND METHOD...

journal_title：Biochemical and biophysical research communications

authors： Koukourakis MI,Kalamida D,Mitrakas A,Pouliliou S,Kalamida S,Sivridis E,Giatromanolaki A

更新日期：2015-05-29 00:00:00

abstract：:Two ornithine transcarbamylase-deficient mice are available, the spf with a variant enzyme and spf-ash with a markedly decreased enzyme protein. Genomic DNA, mRNA and the nuclear precursors for the enzyme in these mutants were analyzed. Southern blot analysis of genomic DNA showed no abnormality in the mutant mice. Bl...

journal_title：Biochemical and biophysical research communications

authors： Ohtake A,Takayanagi M,Yamamoto S,Nakajima H,Mori M

更新日期：1987-08-14 00:00:00

abstract：OBJECTIVE:LeftyA, a powerful regulator of stemness, embryonic differentiation, and reprogramming of cancer cells, counteracts cell proliferation and tumor growth. Key properties of tumor cells include enhanced glycolytic flux, which is highly sensitive to cytosolic pH and thus requires export of H(+) and lactate. H(+) ...

journal_title：Biochemical and biophysical research communications

authors： Salker MS,Zhou Y,Singh Y,Brosens J,Lang F

更新日期：2015-05-08 00:00:00

abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

journal_title：Biochemical and biophysical research communications

authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

更新日期：2005-10-28 00:00:00

abstract：:(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Büttner G,Pittelkow MR,Wood JM,Swanson NN,Körner C

更新日期：1994-10-14 00:00:00

abstract：:We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 ami...

journal_title：Biochemical and biophysical research communications

authors： Yokoyama S,Shirataki H,Sakisaka T,Takai Y

更新日期：1999-03-05 00:00:00

abstract：:Histamine induced a concentration-dependent increase in intracellular cyclic-AMP of the two human melanoma cell lines SK23 and DX3.LT5.1; maximal stimulation was obtained with 17.8 microM histamine which consistently produced greater than 50-fold increases in the cyclic AMP content of both cell lines. The dose-respons...

journal_title：Biochemical and biophysical research communications

authors： Whitehead RJ,Taylor DJ,Evanson JM,Hart IR,Woolley DE

更新日期：1988-02-29 00:00:00

abstract：:Although the regeneration of the adult liver depends on hepatic progenitor cells (HPCs), many uncertainties regarding hepatic regeneration in the injured liver remain. Trefoil factor family 1 (TFF1), a secretory protein predominantly expressed in the gastrointestinal tract, is responsible for mucosal restitution. Here...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Yamaguchi J,Kokuryo T,Ebata T,Yokoyama Y,Nagino M

更新日期：2018-11-17 00:00:00

abstract：:The presence of type I transglutaminase was determined in the neoplastic human keratinocyte line SqCC/Y1 and in normal human epidermal keratinocytes (NHEK) by an in situ radioimmunoassay which corresponded directly with the measurement of type I transglutaminase enzymatic activity. Dexamethasone induced differentiatio...

journal_title：Biochemical and biophysical research communications

authors： Moore KG,Donadio AC,Sartorelli AC

更新日期：1993-04-30 00:00:00

abstract：:Intestinal N-acetylglucosamine 6-O-sulfotransferase (I-GlcNAc6ST, GST-4alpha) and corneal N-acetylglucosamine 6-O-sulfotransferases (C-GlcNAc6ST, GST-4beta) are two highly homologous GlcNAc 6-O-sulfotransferase isozymes encoded by two intronless open reading frames that reside approximately 50 kb apart on human chromo...

journal_title：Biochemical and biophysical research communications

authors： Bartes A,Bhakta S,Hemmerich S

更新日期：2001-04-13 00:00:00

abstract：:Although many advances have been made in the treatment of gastric cancer (GC), numerous difficulties, such as the emergence of chemo-drug resistance, continue to lead to disappointing GC prognoses. Thus, novel alternative strategies are urgently needed. The use of natural products could be a viable option to treat GC....

journal_title：Biochemical and biophysical research communications

authors： Zhou Q,Wu X,Wen C,Wang H,Wang H,Liu H,Peng J

更新日期：2018-10-20 00:00:00

abstract：:Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+]i) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spo...

journal_title：Biochemical and biophysical research communications

authors： Takizawa M,Harada K,Nakamura K,Tsuboi T

更新日期：2018-07-02 00:00:00

abstract：:In the present study, we examined the effects and action mechanisms of cGMP-elevating agents on platelet adhesion to collagen fiber. YC-1, a nitric oxide (NO)-independent activator of soluble guanylate cyclase, inhibited both initial and long-term platelet adhesion to collagen, and the inhibitory effect was potentiate...

journal_title：Biochemical and biophysical research communications

authors： Wu CC,Ko FN,Teng CM

更新日期：1997-02-13 00:00:00

abstract：:The Wnt/β-catenin signaling pathway, also known as the canonical Wnt pathway, plays a role in cell proliferation and differentiation in several tissues/organs. It has been recently described in humans a relationship between type 2 diabetes (T2DM) and mutation in the gene encoding the transcription factor TCF7L2 associ...

journal_title：Biochemical and biophysical research communications

authors： Maschio DA,Oliveira RB,Santos MR,Carvalho CP,Barbosa-Sampaio HC,Collares-Buzato CB

更新日期：2016-09-30 00:00:00