2'-O-methyl-1-methyl adenosine: a new modified nucleoside in ragi (Eleusine coracana) tRNA.

abstract：:NGA is a human melanoma-associated antigen recognized by a panel of murine monoclonal antibodies developed in this laboratory. NGA consists of a 23.5 kDa core protein which is glycosylated in vivo to give a family of glycoproteins (30-60 kDa). Treatment of human melanoma G361 cells with the phorbol ester PMA resulted ...

journal_title：Biochemical and biophysical research communications

authors： Feyles V,Dixon WT,Sikora LK,Jerry LM

更新日期：1989-02-15 00:00:00

abstract：:Myeloperoxidase (MPO) is a glycosylated heme-containing enzyme present in the azurophilic granules of normal human polymorphonuclear neutrophils. This enzyme plays a major role in the microbicidal activity of the host defense system by catalyzing the formation of the potent oxidant, hypochlorous acid. Although the ami...

journal_title：Biochemical and biophysical research communications

authors： Taylor KL,Uhlinger DJ,Kinkade JM Jr

更新日期：1992-09-30 00:00:00

abstract：:The 5'-untranslated sequence of tobacco mosaic virus RNA--the so called omega leader--is a well-known translational enhancer. The structure of the omega RNA has unusual features. Despite the absence of extensive secondary structure of the Watson-Crick type, the omega RNA possesses a stable compact conformation. The ce...

journal_title：Biochemical and biophysical research communications

authors： Agalarov SC,Sogorin EA,Shirokikh NE,Spirin AS

更新日期：2011-01-07 00:00:00

abstract：:Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen. In the present st...

journal_title：Biochemical and biophysical research communications

authors： Krishnamurthi S,Kakkar VV

更新日期：1988-11-15 00:00:00

abstract：:A real-time RT-PCR assay using newly designed primers was developed to analyze developmental and adult MHC mRNA expression both in skeletal muscles and single fibers. Only 4 ng of total RNA was necessary for the analysis of the relative mRNA expression of MHC genes. Different validation steps were realized concerning ...

journal_title：Biochemical and biophysical research communications

authors： Sanchez H,Chapot R,Banzet S,Koulmann N,Birot O,Bigard AX,Peinnequin A

更新日期：2006-02-03 00:00:00

abstract：AIMS:Mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) result in lipodystrophy, insulin resistance and diabetes. Autophagy is required for normal adipogenesis and adipose tissue development. The aim of this study was to determine whether impaired autophagy or excessive cell death underlie the adipoge...

journal_title：Biochemical and biophysical research communications

authors： Fernández-Galilea M,Tapia P,Cautivo K,Morselli E,Cortés VA

更新日期：2015-11-06 00:00:00

abstract：:To examine the possibility that inter-individual differences in splicing partially explain the observed differences in CYP2D6 activity, we amplified its full-length cDNA in 96 human liver RNA samples and discovered five splice variants: intron 5 retention, intron 6 retention, intron 5 and intron 6 double retention, ex...

journal_title：Biochemical and biophysical research communications

authors： Denson J,Wu Y,Yang W,Zhang J

更新日期：2005-05-06 00:00:00

abstract：:A human thyroid cDNA library was screened by hybridization with a dog thyrotropin receptor (TSHr) cDNA. Sequencing of the resulting clones identified a 2292 residue open reading frame encoding a 744 amino acid mature polypeptide presenting 90.3% similarity with the dog TSHr. Two major transcripts (4.6 and 4.4 kilobase...

journal_title：Biochemical and biophysical research communications

authors： Libert F,Lefort A,Gerard C,Parmentier M,Perret J,Ludgate M,Dumont JE,Vassart G

更新日期：1989-12-29 00:00:00

abstract：:The poly(rC)-binding protein PCBP2 has multiple functions in post-transcriptional control of host and viral gene expression. Since it interacts with picornaviral RNA structures, it was proposed that PCBP2 regulates viral genome translation and replication. The hepatitis A virus (HAV), an atypical picornavirus, contain...

journal_title：Biochemical and biophysical research communications

authors： Zhang B,Seitz S,Kusov Y,Zell R,Gauss-Müller V

更新日期：2007-12-28 00:00:00

abstract：:To explore the estrogen-regulated genes genome-widely in breast cancer, cap analysis of gene expression (CAGE) sequencing was performed in MCF-7 cells under estrogen treatment. Estrogen-regulated expressional changes were found in 1537 CAGE tag clusters (TCs) (⩾1.5 or ⩽0.66-folds). Among them, 15 TCs were situated in ...

journal_title：Biochemical and biophysical research communications

authors： Yamaga R,Ikeda K,Boele J,Horie-Inoue K,Takayama K,Urano T,Kaida K,Carninci P,Kawai J,Hayashizaki Y,Ouchi Y,de Hoon M,Inoue S

更新日期：2014-05-09 00:00:00

abstract：:Six healthy subjects were given endothelin-1, intravenously in a dose of 4 pmol.kg-1.min-1 for 20 min. Blood samples were drawn from arterial, hepatic and renal vein catheters for determinations of splanchnic and renal blood flows and the extraction of endothelin-1 in these vascular beds. Intravenous infusion of endot...

journal_title：Biochemical and biophysical research communications

authors： Weitzberg E,Ahlborg G,Lundberg JM

更新日期：1991-11-14 00:00:00

abstract：:Insulin activates the glucose transport in isolated fat cells through a translocation of the insulin sensitive glucose carrier subtype (GLUT4) and by activation of glucose carriers in the plasma membrane. Protein kinase C stimulating phorbol esters are able to mimick partially the insulin effect on glucose transport. ...

journal_title：Biochemical and biophysical research communications

authors： Vogt B,Mushack J,Seffer E,Häring HU

更新日期：1990-05-16 00:00:00

abstract：:Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2002-10-04 00:00:00

abstract：:The Crk and CrkL adaptor proteins have SH2 and SH3 domains and play essential overlapping, as well as distinct, roles in many biological processes, ranging from cell structure and motility to proliferation. Conditional ablation of both Crk and CrkL in neuronal progenitor cells, using a Nestin-Cre transgene, resulted i...

journal_title：Biochemical and biophysical research communications

authors： Park T,Curran T

更新日期：2020-08-27 00:00:00

abstract：:Recent research revealed that doxorubicin (DOX) decreased expression of programmed death-ligand 1 (PD-L1) in cancer cells. However, the detailed mechanisms underlying this effect are not well established. Here, we demonstrate that doxorubicin down-regulates PD-L1 expression through induction of AU-rich element (ARE) b...

journal_title：Biochemical and biophysical research communications

authors： Kim DJ,Jang JH,Ham SY,Choi SH,Park SS,Jeong SY,Kim BC,Jeon DY,Lee BJ,Ko BK,Park JW,Cho WJ

更新日期：2020-02-05 00:00:00

abstract：:Xanthine oxidase (XO) was found to convert nitric oxide (NO* ) released from spermine-NONOate to nitroxyl (HNO), the one-electron reduction product of NO*, in the presence of its substrate hypoxanthine under anaerobic conditions. Under these conditions, XO lost its activity. Upon aerobic incubation of XO with its subs...

journal_title：Biochemical and biophysical research communications

authors： Saleem M,Ohshima H

更新日期：2004-03-05 00:00:00

abstract：:We examined the possibility that bilirubin physiologically acts as an antioxidant by using scurvy-prone ODS-od/od rats treated with endotoxin (lipopolysaccharide: LPS). Recently, bilirubin oxidative metabolites were isolated from human urine and named biotripyrrin-a and biotripyrrin-b. The LPS injection markedly incre...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Horio F,Hashizume T,Tanaka M,Ikeda S,Kakinuma A,Nakajima H

更新日期：1995-09-05 00:00:00

abstract：:Cardiac ventricular myocytes exhibit a protein kinase A-dependent Cl(-) current (ICl.PKA) mediated by the cystic fibrosis transmembrane conductance regulator (CFTR). There is conflicting evidence regarding the ability of the divalent cation nickel (Ni(2+)), which has been used widely in vitro in the study of other car...

journal_title：Biochemical and biophysical research communications

authors： Barman PP,Cheng H,Hancox JC,James AF

更新日期：2013-03-01 00:00:00

abstract：:Nuclear orphan receptor TLX is an essential regulator of the growth of neural stem cells. However, its exact function in pancreatic islet cells is still unknown. In the present study, gene expression profiling analysis revealed that overexpression of TLX in beta cell line MIN6 causes suppression of 176 genes and upreg...

journal_title：Biochemical and biophysical research communications

authors： Shi X,Xiong X,Dai Z,Deng H,Sun L,Hu X,Zhou F,Xu Y

更新日期：2015-12-04 00:00:00

abstract：:The transcription factor sterol regulatory element-binding protein 1c (SREBP1c) plays an important role in the control of fatty acid metabolism in the liver. Evidence suggests that mammalian target of rapamycin (mTOR) complex 1 (mTORC1) contributes to the regulation of SREBP1c expression, but signaling downstream of m...

journal_title：Biochemical and biophysical research communications

authors： Li S,Ogawa W,Emi A,Hayashi K,Senga Y,Nomura K,Hara K,Yu D,Kasuga M

更新日期：2011-08-26 00:00:00

abstract：:alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme's active site. Here, we show that the C-terminal lysine residue of AP has a key role in binding of the inhibitor to plasmin. A syn...

journal_title：Biochemical and biophysical research communications

authors： Hortin GL,Gibson BL,Fok KF

更新日期：1988-09-15 00:00:00

abstract：:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs p...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

更新日期：2008-05-02 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action and expression in human pancreatic cancer cell lines, and compared HB-...

journal_title：Biochemical and biophysical research communications

authors： Kobrin MS,Funatomi H,Friess H,Buchler MW,Stathis P,Korc M

更新日期：1994-08-15 00:00:00

abstract：:The energization of rho + and rho degrees isolated mitochondria was measured using a tetraphenylphosphonium selective electrode. In both strains translocase mediated ATP/ADP exchange energization was observed. This energization was more sensitive to uncoupler than that induced by respiration in rho + mitochondria. Thi...

journal_title：Biochemical and biophysical research communications

authors： Dupont CH,Mazat JP,Guerin B

更新日期：1985-11-15 00:00:00

abstract：:A synthetic peptide, selected in the predicted N-terminal amino-acid sequence of the purine cytosine permease (gene FCY2), linked to albumins proved a remarkably good immunogen in rabbits. In ELISA, sera reacted with the synthetic peptide and with specific proteins of plasma-membrane-enriched fractions of mutant Sacch...

journal_title：Biochemical and biophysical research communications

authors： Grandier-Vazeille X,Neaud V,Geoffre S

更新日期：1993-12-15 00:00:00

abstract：:Inducible nitric oxide (iNOS) is closely correlated with chronic inflammation in hepatitis B virus X protein (HBx)-induced hepatocellular carcinoma (HCC). However, the molecular mechanisms through which iNOS contribute to hepatocarcinogenesis remain poorly understood. Therefore, we investigated the role of iNOS in sig...

journal_title：Biochemical and biophysical research communications

authors： Park YH,Shin HJ,Kim SU,Kim JM,Kim JH,Bang DH,Chang KT,Kim BY,Yu DY

更新日期：2013-05-31 00:00:00

abstract：:The possible formation of a stable complex between extracellular signal-regulated kinases (ERKs) and Raf protein kinases was investigated in an attempt to understand the molecular mechanism by which Raf protein kinases were differentially regulated in response to the various stimuli, leading to the activation of ERKs ...

journal_title：Biochemical and biophysical research communications

authors： Kim SH,Yang YC

更新日期：1996-12-13 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in patients with PCOS...

journal_title：Biochemical and biophysical research communications

authors： Yu CJ,Liu X,Zhou ZY,Chen XJ,Meng YC,Gu HC,Xu JJ,Ding GL,Liu XM,Sheng JZ,Huang HF

更新日期：2020-02-17 00:00:00

abstract：:Number and molecular Brightness (N&B) analysis is a powerful method used to monitor protein aggregation in living cells. Here, we used the N&B method to characterize the unexpanded HTT protein oligomerization after the internalization of the mutant HTT (mHTT) which contains a CAG repeat extensions encoding for long po...

journal_title：Biochemical and biophysical research communications

authors： Sameni S,Zhang R,Digman MA

更新日期：2020-01-29 00:00:00

abstract：:Three mRNA species for human muscle phophofructokinase containing heterogeneous 5' untranslated sequences were identified through cDNA cloning. Type A mRNA was essentially the same as that reported previously (Nakajima, H., et al. (1987) FEBS Lett. 223, 113). Type B mRNA was considered to be the major gene product, wh...

journal_title：Biochemical and biophysical research communications

authors： Nakajima H,Yamasaki T,Noguchi T,Tanaka T,Kono N,Tarui S

更新日期：1990-01-30 00:00:00