Analysis of an intronic promoter within Synj2.

abstract：:Chorea-acanthocytosis (ChAc) is a hereditary neurodegenerative disorder caused by loss of function mutations in the VPS13A gene encoding chorein. Recently, using a gene-targeting technique to delete exons 60-61, we produced a ChAc-model mouse that corresponds to a human disease mutation. In this study, a comparative m...

journal_title：Biochemical and biophysical research communications

authors： Kurano Y,Nakamura M,Ichiba M,Matsuda M,Mizuno E,Kato M,Izumo S,Sano A

更新日期：2006-12-15 00:00:00

abstract：:G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions. In this short article, we will first describe recent ...

journal_title：Biochemical and biophysical research communications

authors： Masai H,Tanaka T

更新日期：2020-10-08 00:00:00

abstract：:The factors which control the formation of lactiferous ducts during mammary gland development are not yet fully understood. To address this issue, we assessed the effect of the multifunctional cytokine transforming growth factor-beta-1 (TGF-beta1) on the morphogenetic properties of TAC-2.1 mammary epithelial cells gro...

journal_title：Biochemical and biophysical research communications

authors： Soriano JV,Orci L,Montesano R

更新日期：1996-03-27 00:00:00

abstract：:In the course of the eukaryotic ribosomal biogenesis, both the nuclear import and export are involved. We have studied the nuclear and nucleolar localization of the human ribosomal protein S7. We examined the subcellular distribution of the S7:beta-galactosidase fusion protein in SAOS-2 cells. We have identified two e...

journal_title：Biochemical and biophysical research communications

authors： Annilo T,Karis A,Hoth S,Rikk T,Kruppa J,Metspalu A

更新日期：1998-08-28 00:00:00

abstract：:Hippocampal slices offer an excellent experimental system for the study of activity-induced changes in the postsynaptic density (PSD). While studies have documented electrophysiological and structural changes at synapses in response to precise manipulations of hippocampal slices, parallel biochemical and proteomic ana...

journal_title：Biochemical and biophysical research communications

authors： Dosemeci A,Tao-Cheng JH,Vinade L,Jaffe H

更新日期：2006-01-13 00:00:00

abstract：:During embryonic development of Musca domestica inactive ornithine decarboxylase protein appears in the embryos at 6 h postoviposition, increases in concentration and reaches a maximum level at 9 h postoviposition. The inactive enzyme is associated with the plasma membrane and appears to be the precursor for active or...

journal_title：Biochemical and biophysical research communications

authors： Lilleberg SL,Killilea SD,Vaske DA,Leopold RA,Sparks RB Jr

更新日期：1991-01-31 00:00:00

abstract：:Mizoribine (MIZ) is a novel imidazole nucleoside with immunosuppressive activity. MIZ has been approved in Japan and combination therapy with MIZ and glucocorticoids has been used after renal transplantation and for lupus nephritis and rheumatoid arthritis. In this study, we identify 14-3-3 proteins as MIZ-binding pro...

journal_title：Biochemical and biophysical research communications

authors： Takahashi S,Wakui H,Gustafsson JA,Zilliacus J,Itoh H

更新日期：2000-07-21 00:00:00

abstract：:Mesenchymal stem cells (MSCs) isolated from several adult human tissues are reported to be a promising tool for regenerative medicine. In order to broaden the array of tools for therapeutic application, we isolated a new population of cells from adult human testis termed gonadal stem cells (GSCs). GSCs express CD105, ...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez R,Griparic L,Vargas V,Burgee K,Santacruz P,Anderson R,Schiewe M,Silva F,Patel A

更新日期：2009-08-07 00:00:00

abstract：:The extended exposure of proteins to reducing sugars leads to nonenzymatic glycation with the accumulation of advanced glycation end products (AGEs). Long-lived proteins, such as collagen and crystallins, are subjected to this modification, and are implicated as causal factors in several diseases including diabetic co...

journal_title：Biochemical and biophysical research communications

authors： Hong SB,Lee KW,Handa JT,Joo CK

更新日期：2000-08-18 00:00:00

abstract：:Heme oxygenase-1, an essential enzyme in heme catabolism, and metallothionein IIA, a small metal-binding protein with clusters of cysteins, are remarkably induced in HeLa cells following the treatment with cadmium or zinc. Both proteins are considered to be involved in the defense system against metal toxicity. Here w...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Fujita H,Shibahara S

更新日期：1995-02-06 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

journal_title：Biochemical and biophysical research communications

authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

更新日期：1986-05-29 00:00:00

abstract：:Vaccination evoking immunity in susceptible individuals has become the most effective solution to combat infectious diseases. The surface antigen of hepatitis B virus (HBsAg) is a mandatory vaccine for children in China. Herein, we designed an antimicrobial protein consisting of an antimicrobial peptide Thanatin at th...

journal_title：Biochemical and biophysical research communications

authors： Fan X,Xu W,Gao W,Xiao H,Wu G

更新日期：2021-01-01 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:Anthracycline derivatives such as doxorubicin are part of many chemotherapeutic regimens and reach peak plasma concentrations of 5 microM. We investigated the cytotoxic mechanisms of various doxorubicin concentrations in MOLT-4 ALL-cells. Concentrations of up to 100 microM doxorubicin achieved similar cytotoxic effect...

journal_title：Biochemical and biophysical research communications

authors： Müller I,Jenner A,Bruchelt G,Niethammer D,Halliwell B

更新日期：1997-01-13 00:00:00

abstract：:In our efforts to identify immunoreactive antigens in ovarian cancer, we used the method of immunoscreening of an ovarian carcinoma cDNA expression library with ascites fluid from ovarian cancer patients. Among many positive clones, one was found to contain partial sequence of a novel gene. By searching expressed sequ...

journal_title：Biochemical and biophysical research communications

authors： Luo LY,Soosaipillai A,Diamandis EP

更新日期：2001-01-12 00:00:00

abstract：:Sulfoquinovosyl diacylglycerol is one of the lipids that construct thylakoid membranes, and is distributed from cyanobacteria to plastids in plants including a red lineage. One of the most primitive red algae, Cyanidioschyzon melorae, similar to cyanobacteria and green plants, possesses homologs of the SQD1 and SQD2 g...

journal_title：Biochemical and biophysical research communications

authors： Sato N,Kobayashi S,Aoki M,Umemura T,Kobayashi I,Tsuzuki M

更新日期：2016-01-29 00:00:00

abstract：:The purpose of this study was to identify mammalian cell line(s) which possess intrinsic enzymatic activity of beta-carotene 15, 15'-dioxygenase. This enzyme (EC1.13.11.21) converts beta-carotene to retinal (precursor of retinol and retinoic acid). To assess activity, cellular enzyme preparations were incubated with b...

journal_title：Biochemical and biophysical research communications

authors： During A,Albaugh G,Smith JC Jr

更新日期：1998-08-19 00:00:00

abstract：:The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce d...

journal_title：Biochemical and biophysical research communications

authors： Aggarwal P,Padmanabhan B,Bhat A,Sarvepalli K,Sadhale PP,Nath U

更新日期：2011-07-01 00:00:00

abstract：:To date, little is known about the molecular mechanisms controlling the regulation of phospholipase C-delta1 (PLC-delta1) gene expression. To understand the mechanisms responsible for the regulation of PLC-delta1 gene expression, the 5'-flanking region of the mouse PLC-delta1 gene was isolated from a mouse genomic DNA...

journal_title：Biochemical and biophysical research communications

authors： Kim JK,Lee WK,Nam HW,Lee KH,Han H,Rha HK,Jun TY,Kim KS,Choi CR

更新日期：2000-06-24 00:00:00

abstract：:Sensitization to Cupressaceae pollen has become one of the most important causes of pollinosis in Western countries during winter and early spring. However, the characterization of the extracts, the allergens involved and the cross-reactivity with other pollen sources still remain poorly studied; in the case of Cupres...

journal_title：Biochemical and biophysical research communications

authors： Pico de Coaña Y,Parody N,Fuertes MÁ,Carnés J,Roncarolo D,Ariano R,Sastre J,Mistrello G,Alonso C

更新日期：2010-10-22 00:00:00

abstract：:Significant attention has been given to the role played by non-hematopoietic cells in the immune organs, including the lymph nodes, in hopes of understanding the development, maintenance, and regulation of the immune system. However, the molecular and cellular characterization of non-hematopoietic cells is still in it...

journal_title：Biochemical and biophysical research communications

authors： Togoo K,Takahama Y,Takada K

更新日期：2014-06-27 00:00:00

abstract：:Under standard conditions, in the presence of GTP, highly purified eIF-2 and Co-eIF-2 factor preparations efficiently stimulated AUG-codon dependent but not physiological mRNA-dependent Met-tRNAf binding to 40S ribosomes. Replacement of GTP by a nonhydrolyzable GTP analog, GMP-PNP, in the above system, gave significan...

journal_title：Biochemical and biophysical research communications

authors： Roy R,Nasrin N,Ahmad MF,Gupta NK

更新日期：1984-08-16 00:00:00

abstract：:Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No c...

journal_title：Biochemical and biophysical research communications

authors： Mizuno Y,Ohta S,Tanaka M,Takamiya S,Suzuki K,Sato T,Oya H,Ozawa T,Kagawa Y

更新日期：1989-09-29 00:00:00

abstract：:The calmodulin-stimulated ATPase of maize coleoptiles is a 140,000 Mr polypeptide. In the present study, formation of a phosphorylated intermediate by the enzyme is demonstrated. Phosphorylation is sensitive to chasing with unlabelled ATP and to hydroxylamine; lanthanum enhances its intensity while calmodulin enhances...

journal_title：Biochemical and biophysical research communications

authors： Briars SA,Evans DE

更新日期：1989-02-28 00:00:00

abstract：:BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD-like receptor containing pyrin domain 3 (NLRP3). We reported the involvement of neuronal ...

journal_title：Biochemical and biophysical research communications

authors： Cheng X,Xu S,Zhang C,Qin K,Yan J,Shao X

更新日期：2020-02-12 00:00:00

abstract：:Rhodanese domains are abundant structural modules that catalyze the transfer of a sulfur atom from thiolsulfates to cyanide via formation of a covalent persulfide intermediate that is bound to an essential conserved cysteine residue. In this study, the three-dimensional structure of the rhodanese domain of YgaP from E...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Zhou P,He Y,Yu L,Xiong Y,Tian C,Wu F

更新日期：2014-09-26 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:We have synthesized the first enkephalin analog containing a "cyclopropyl" phenylalanine (Phe) residue. The E-configuration of this residue is apparently responsible for its low activity in the MVD and GPI muscle assays. The enkephalin is very stable to cleavage by carboxypeptidase Y. ...

journal_title：Biochemical and biophysical research communications

authors： Kimura H,Stammer CH,Shimohigashi Y,Ren-Lin C,Stewart J

更新日期：1983-08-30 00:00:00

abstract：:When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant myc...

journal_title：Biochemical and biophysical research communications

authors： Nes WD,Hanners PK,Parish EJ

更新日期：1986-09-14 00:00:00