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Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.

Abstract：

:Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mizuno Y,Ohta S,Tanaka M,Takamiya S,Suzuki K,Sato T,Oya H,Ozawa T,Kagawa Y

doi

10.1016/0006-291x(89)91141-8

subject

Has Abstract

pub_date

1989-09-29 00:00:00

pages

1450-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91141-8

journal_volume

163

pub_type

杂志文章

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