Evidence for an inactive plasma membrane-associated precursor of active cytoplasmic ornithine decarboxylase in developing embryos of Musca domestica.

abstract：:FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing ...

journal_title：Biochemical and biophysical research communications

authors： Ma C,Peng C,Lu X,Ding X,Zhang S,Zou X,Zhang X

更新日期：2015-03-06 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00

abstract：:18,54-SF cells, which secrete rat insulin-like growth factor II (rIGF-II), have abundant type 2 IGF receptors. We have purified the type 2 receptor from these cells by solubilization of crude membranes in Triton X-100, followed by chromatography on agarose-immobilized rIGF-II. A partially purified receptor preparation...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld RG,Hodges D,Pham H,Lee PD,Powell DR

更新日期：1986-07-16 00:00:00

abstract：:The tumor suppressor, RASSF2 (Ras association domain family 2), is frequently downregulated in a number of cancers. Although exogenously expressed RASSF2 induces apoptotic cell death, the precise roles of RASSF2 under pro-apoptotic conditions remain largely unknown. Here, we demonstrate that MST1 (mammalian sterile 20...

journal_title：Biochemical and biophysical research communications

authors： Song H,Oh S,Oh HJ,Lim DS

更新日期：2010-01-01 00:00:00

abstract：:Epitopic peptides representing the C-terminal (HA1) region of cleaved hemagglutinin of influenza virus from different serotypes were synthesized. Circular dichroism and Fourier-transform infrared spectroscopic data showed that peptides HS2 and HS3 have a predominantly alpha-helical conformation in trifluoroethanol. Re...

journal_title：Biochemical and biophysical research communications

authors： Holly S,Majer Z,Tóth GK,Váradi G,Rajnavölgyi E,Laczkó I,Hollósi M

更新日期：1993-06-30 00:00:00

abstract：:The growth of DU-145 human prostate carcinoma cells is reduced to 50% of control by 1 X 10(-6) M to 2 X 10(-6) M selenium and to 2% of control at 10(-4)M selenium. These cells show greater sensitivity to inhibition of growth or DNA synthesis by selenium than human W1-38 and HeLa cells and mouse mammary tumor cells. It...

journal_title：Biochemical and biophysical research communications

authors： Webber MM,Perez-Ripoll EA,James GT

更新日期：1985-07-31 00:00:00

abstract：:The factors responsible for up-regulation of PTP1B, a negative regulator of insulin signaling, in insulin resistance state are not well understood. We performed a series of experiments in C2C12 muscle cells to determine the role of palmitate and an inflammatory state in regulation of PTP1B. Palmitate (0.75mM) induced ...

journal_title：Biochemical and biophysical research communications

authors： Parvaneh L,Meshkani R,Bakhtiyari S,Mohammadtaghvaie N,Gorganifiruzjaee S,Taheripak G,Golestani A,Foruzandeh M,Larijani B,Taghikhani M

更新日期：2010-05-28 00:00:00

abstract：:It has been suggested that stress stimuli from the microenvironment maintain a subset of tumor cells with stem-like properties, including drug resistance. Here, we investigate whether Sp1, a stress-responsive factor, regulates stemness gene expression and if its inhibition sensitizes cancer cells to chemotherapy. Hydr...

journal_title：Biochemical and biophysical research communications

authors： Chang KY,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK,Hung JJ,Chang WC,Tsai KK,Chuang JY

更新日期：2017-11-04 00:00:00

abstract：:Disproportionate hyperproinsulinemia is an indicator of β-cell dysfunction in diabetes and the basis underlying this abnormality remains obscure. Recently, we have found proinsulin is an aggregation-prone molecule inherent with a low relative folding rate and maintains a homeostatic balance of natively and plentiful n...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Osei K

更新日期：2011-07-22 00:00:00

abstract：:Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the ...

journal_title：Biochemical and biophysical research communications

authors： Cai ZY,Yang B,Shi YX,Zhang WL,Liu F,Zhao W,Yang MW

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been demonstrated to be intensively involved in the development of various carcinomas, including glioblastoma multiforme (GBM). However, only a few of them have been well characterized. LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tis...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Dai W,Wang H,Pan H,Wang Q

更新日期：2018-06-12 00:00:00

abstract：:We established a simple and highly efficient method for in vivo gene transfer using HVJ (Sendai virus) and liposomes. Plasmid DNA and high mobility group 1 (HMG1) protein were co-encapsulated in liposomes by agitation and sonication and were co-introduced into cells by HVJ-mediated membrane fusion. pACT SVT DNA, as a ...

journal_title：Biochemical and biophysical research communications

authors： Tomita N,Higaki J,Morishita R,Kato K,Mikami H,Kaneda Y,Ogihara T

更新日期：1992-07-15 00:00:00

abstract：:We used fluorescence in situ hybridization (FISH) to detect c-myc RNA subspecies in human COLO 320DM tumor cells. Although the FISH procedure removed the majority of RNAs from the nucleolus, c-myc RNA continued to be detected in both the nucleoplasm and nucleolus. This finding suggests stable association between c-myc...

journal_title：Biochemical and biophysical research communications

authors： Shimizu N,Kawamoto JK,Utani K

更新日期：2007-08-03 00:00:00

abstract：:Polycystin-1 (PC1) is a membrane protein expressed in tubular epithelia of developing kidneys and in other ductal structures. Recent studies indicate this protein to be putatively important in regulating intracellular Ca(2+) levels in various cell types, but little evidence exists for kidney epithelial cells. Here we ...

journal_title：Biochemical and biophysical research communications

authors： Aguiari G,Campanella M,Manzati E,Pinton P,Banzi M,Moretti S,Piva R,Rizzuto R,del Senno L

更新日期：2003-02-14 00:00:00

abstract：:Osteoclasts which derive from hemopoietic cells are multinucleated cells responsible for bone resorption. We found that cyclopiazonic acid (CPA), thapsigargin (TG), and 2,5-di-(t-butyl)-1,4-hydroquinone (BHQ) induced osteoclast-like cell (OCL) formation in cocultures of mouse calvaria-derived stromal cells and hemopoi...

journal_title：Biochemical and biophysical research communications

authors： Takami M,Woo JT,Takahashi N,Suda T,Nagai K

更新日期：1997-08-08 00:00:00

abstract：:This study addresses the role of nitric oxide (NO) and downstream signaling pathways in mediating the influences of oscillatory shear stress on the hydraulic conductivity (L(p)) of bovine aortic endothelial cell (BAEC) monolayers. Exposure of BAEC monolayers to 20 dyne/cm2 steady shear stress for 3 h induced a 3.3-fol...

journal_title：Biochemical and biophysical research communications

authors： Hillsley MV,Tarbell JM

更新日期：2002-05-24 00:00:00

abstract：:Transthyretin (TTR) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP). FAP typically results in severe and early-onset disease, and the only therapy established so far is liver transplantation; thus, developin...

journal_title：Biochemical and biophysical research communications

authors： Lee KW,Lee DH,Son H,Kim YS,Park JY,Roh GS,Kim HJ,Kang SS,Cho GJ,Choi WS

更新日期：2009-10-16 00:00:00

abstract：:Intracellular Ca2+ oscillations in fertilized mammalian eggs, the key signal that stimulates egg activation and early embryonic development, are regulated by inositol 1,4,5-trisphosphate (IP3) signaling pathway. We investigated temporal changes in intracellular IP3 concentration ([IP3]i) in mouse eggs, using a fluores...

journal_title：Biochemical and biophysical research communications

authors： Shirakawa H,Ito M,Sato M,Umezawa Y,Miyazaki S

更新日期：2006-06-30 00:00:00

abstract：:The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D(3), plays an important role not only in the establishment and maintenance of calcium metabolism, but also in regulating cell growth and differentiation. Because the clinical usefulness of 1,25-dihydroxyvitamin D(3) is limited by its tendency to caus...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Steinmeyer A,Steinhilber D,Stein J

更新日期：2002-01-11 00:00:00

abstract：:4 beta phorbol-12, 13-dibutyrate (PDBu) stimulated cyclic AMP accumulation in GH3 pituitary tumour cells in the presence of isobutylmethylxanthine. This effect persisted after preincubation of cells with cholera or pertussis toxins. In contrast, vasoactive intestinal polypeptide (VIP)-stimulated cyclic AMP accumulatio...

journal_title：Biochemical and biophysical research communications

authors： Quilliam LA,Dobson PR,Brown BL

更新日期：1985-06-28 00:00:00

abstract：:Corticotropin-releasing factor (CRF) increased intracellular Ca2+ concentration in single astrocytes. The effect in increasing intracellular Ca2+ was not observed in Ca2(+)-free solution. Furthermore, CRF at concentrations more than 10 nM stimulated 45Ca2+ uptake in cultured rat astrocytes. The action was blocked by a...

journal_title：Biochemical and biophysical research communications

authors： Takuma K,Matsuda T,Yoshikawa T,Kitanaka J,Gotoh M,Hayata K,Baba A

更新日期：1994-03-30 00:00:00

abstract：:BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells...

journal_title：Biochemical and biophysical research communications

authors： Yi E,Oh J,Kang HR,Song MJ,Park SH

更新日期：2019-02-05 00:00:00

abstract：:A family of short interspersed repetitive elements (SINEs), designated mermaid, is present in the genomes of fish, amphibian and primates, but absent in the mouse genome. We have demonstrated that the sequences of the mermaid family are highly polymorphic in the zebrafish genome as in the human genome. We have also sh...

journal_title：Biochemical and biophysical research communications

authors： Shimoda N,Chevrette M,Ekker M,Kikuchi Y,Hotta Y,Okamoto H

更新日期：1996-03-07 00:00:00

abstract：:Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its systemic effects, cellular functions of membranous DPP-4 are less clear. Here we studied the role of DPP-4 in hepatic energy metabolism. In order to distinguish sys...

journal_title：Biochemical and biophysical research communications

authors： Rufinatscha K,Radlinger B,Dobner J,Folie S,Bon C,Profanter E,Ress C,Salzmann K,Staudacher G,Tilg H,Kaser S

更新日期：2017-04-01 00:00:00

abstract：:Dopamine D4 receptor (DRD4) has received attention in terms of pathogenesis of schizophrenia and association with human personalities. We isolated the human DRD4 gene containing the 5'-flanking region and determined its sequence. Analysis of the DRD4 transcripts by 5'-RACE (5'-rapid amplification of cDNA ends) reveale...

journal_title：Biochemical and biophysical research communications

authors： Kamakura S,Iwaki A,Matsumoto M,Fukumaki Y

更新日期：1997-06-18 00:00:00

abstract：:Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part of the DNA-end binding complex, required for proper maintenance of telomeres and contributes to DNA damage recognition and regulation of apoptosis. Forces that r...

journal_title：Biochemical and biophysical research communications

authors： Yurchenko V,Xue Z,Gama V,Matsuyama S,Sadofsky MJ

更新日期：2008-02-01 00:00:00

abstract：:Oleuropein, a non-toxic secoiridoid derived from the olive tree, is a powerful antioxidant and anti-angiogenic agent. Here, we show it to be a potent anti-cancer compound, directly disrupting actin filaments in cells and in a cell-free assay. Oleuropein inhibited the proliferation and migration of advanced-grade tumor...

journal_title：Biochemical and biophysical research communications

authors： Hamdi HK,Castellon R

更新日期：2005-09-02 00:00:00

abstract：:By dimerizing with E2F proteins, TFDP has profound influence on cellular E2F activities. While TFDP1 and 2 enhance the DNA binding and the transcriptional activity of E2F, the newly identified member of the DP family, TFDP3 primarily functions as a negative regulator. To further characterize the inhibitory property of...

journal_title：Biochemical and biophysical research communications

authors： Tian C,Lv D,Qiao H,Zhang J,Yin YH,Qian XP,Wang YP,Zhang Y,Chen WF

更新日期：2007-09-14 00:00:00

abstract：BACKGROUND:In diabetic retinopathy, prolonged high-level blood glucose induced significant impairments among various retinal tissues, including retinal pigment epithelial (RPE) cells. In an in vitro model of human RPE cells, we evaluated whether 7,8-Dihydroxyflavone (DHF) may effectively prevent high glucose-induced di...

journal_title：Biochemical and biophysical research communications

authors： Yu X,Liu Q,Wang X,Liu H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 Vpr is a 96-amino-acid virion-associated protein that arrests cells in the G2 phase of the cell cycle in peripheral blood lymphocytes, HeLa, 293, 293T, A549, Jurkat, CEM, SupT1, CV-1 and COS1 cells. When we transfected Vpr expression vector into mouse NIH3T3 and then cultured it in ...

journal_title：Biochemical and biophysical research communications

authors： Nishino Y,Myojin T,Kamata M,Aida Y

更新日期：1997-03-17 00:00:00