Hyperphosphorylated p47-phox lost the ability to activate NADPH oxidase in guinea pig neutrophils.

abstract：:T-type Ca(2+) channels are important regulators of peripheral sensory neuron excitability. Accordingly, T-type Ca(2+) currents are often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects of inflammation on functional expression of T-type Ca(2+) channe...

journal_title：Biochemical and biophysical research communications

authors： Huang D,Liang C,Zhang F,Men H,Du X,Gamper N,Zhang H

更新日期：2016-04-29 00:00:00

abstract：:To address the role of brain gangliosides in synaptic activity, the ceramide analogs, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and its enantiomer, L-PDMP, were used to inhibit and stimulate ganglioside biosynthesis in cultured cortical neurons. Prolonged treatment with both PDMP isomers exhibi...

journal_title：Biochemical and biophysical research communications

authors： Inokuchi J,Mizutani A,Jimbo M,Usuki S,Yamagishi K,Mochizuki H,Muramoto K,Kobayashi K,Kuroda Y,Iwasaki K,Ohgami Y,Fujiwara M

更新日期：1997-08-28 00:00:00

abstract：OBJECTIVE:Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the under...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Wu JF,Tang YY,Zhang M,Li Y,Chen K,Zeng MY,Yao F,Xie W,Zheng XL,Zeng GF,Tang CK

更新日期：2014-10-03 00:00:00

abstract：:Conjugal transfer of hydrogen-oxidizing ability (Hox) of the hydrogen bacterium Alcaligenes hydrogenophilus was examined. Intraspecific cross of plasmid pHG21-a that encodes hydrogenases that mediate hydrogen oxidation was most frequent at 25 C; the optimal temperature for growth was 30 C. The plasmid could be transfe...

journal_title：Biochemical and biophysical research communications

authors： Umeda F,Min H,Urushihara M,Okazaki M,Miura Y

更新日期：1986-05-29 00:00:00

abstract：:Hepatitis delta virus (HDV) is a human pathogen causing fulminant hepatitis and liver cirrhosis. HDV has a circular single-stranded RNA genome, which encodes only a single protein, hepatitis delta antigen (HDAg), from the antigenomic strand. Although the functional roles of HDAg have been extensively studied, the mole...

journal_title：Biochemical and biophysical research communications

authors： Hwang SB,Park KJ,Kim YS

更新日期：1998-03-27 00:00:00

abstract：:The expression of the ibpAibpB heat-shock operon of Escherichia coli was found previously not to conform to the known pattern of expression of the sigma(32)-regulated operons because the rpoH gene mutation inactivating the sigma(32) protein did not abolish the ibp induction. We show here that this effect can depend pa...

journal_title：Biochemical and biophysical research communications

authors： Kuczyńska-Wisńik D,Laskowska E,Taylor A

更新日期：2001-06-01 00:00:00

abstract：:Apobec1 edits the ApoB mRNA by deaminating nucleotide C(6666), which results in a codon change from Glutamate to stop, and subsequent expression of a truncated protein. Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three...

journal_title：Biochemical and biophysical research communications

authors： Quaresma AJ,Oyama S Jr,Barbosa JA,Kobarg J

更新日期：2006-11-17 00:00:00

abstract：:The effect of guanine nucleotides on activation of the O2-. generating oxidase in a cell free system consisting of bovine neutrophils membranes, cytosol and arachidonic acid has been studied. In a complete system, GTP-gamma-S was stimulatory and GDP-beta-S inhibitory. When cytosol was omitted, both nucleotides acted a...

journal_title：Biochemical and biophysical research communications

authors： Doussiere J,Pilloud MC,Vignais PV

更新日期：1988-05-16 00:00:00

abstract：:In order to test the biological importance of amino acids in the C-terminal quarter of aminoglycoside 3'-phosphotransferase II enzyme, seven of the highly conserved residues in this region, His-188, Asp-190, Asp-208, Gly-210, Arg-211, Asp-216 and Asp-220, were changed via site-directed mutagenesis. The phenotype of ea...

journal_title：Biochemical and biophysical research communications

authors： Kocabiyik S,Perlin MH

更新日期：1992-06-30 00:00:00

abstract：:We have identified a genomic DNA fragment, using the PCR method with degenerate oligonucleotide primers which contain the conserved sequence of the RING finger domain. Using the DNA fragment as a probe, a novel cDNA was cloned from human and mouse testis. The cDNA had a domain structure of the typical RING-B box-coile...

journal_title：Biochemical and biophysical research communications

authors： Orimo A,Yamagishi T,Tominaga N,Yamauchi Y,Hishinuma T,Okada K,Suzuki M,Sato M,Nogi Y,Suzuki H,Inoue S,Yoshimura K,Shimizu Y,Muramatsu M

更新日期：2000-09-16 00:00:00

abstract：:The Sec23p-Sec24p complex is a component of coat protein II-coated vesicles involved in protein export from the endoplasmic reticulum. We previously identified a novel Sec23p-interacting protein, p125, which consists of 1000 amino acids and comprises a proline-rich region and a phospholipase A(1) homology region. p125...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi T,Nakajima K,Hatsuzawa K,Nagahama M,Hauri HP,Tagaya M,Tani K

更新日期：2000-12-09 00:00:00

abstract：:Ribonuclease inhibitors were purified from the latent ribonuclease fractions of porcine thyroid and liver and used to test the hypothesis that their inhibition of bovine pancreatic ribonuclease A is correctly described by tight-binding rather than Michaelis-Menton kinetics. Both proteins were found to act as slow, tig...

journal_title：Biochemical and biophysical research communications

authors： Turner PM,Lerea KM,Kull FJ

更新日期：1983-08-12 00:00:00

abstract：:Fibroblast growth factor (FGF)-23 was identified as a causative factor of tumor-induced osteomalacia and also as a responsible gene for autosomal dominant hypophosphatemic rickets. To clarify the pathophysiological roles of FGF-23 in these diseases, we generated its transgenic mice. The transgenic mice expressing huma...

journal_title：Biochemical and biophysical research communications

authors： Shimada T,Urakawa I,Yamazaki Y,Hasegawa H,Hino R,Yoneya T,Takeuchi Y,Fujita T,Fukumoto S,Yamashita T

更新日期：2004-02-06 00:00:00

abstract：:The Rho-associated coiled-coil kinase (ROCK) family of proteins, including ROCK1 and ROCK2, are key regulators of actin and intermediate filament morphology. The newly discovered ROCK substrate Tubulin polymerization promoting protein 1 (TPPP1) promotes microtubule polymerization and inhibits the activity of Histone d...

journal_title：Biochemical and biophysical research communications

authors： Schofield AV,Gamell C,Bernard O

更新日期：2013-07-12 00:00:00

abstract：:A single base change resulting in the substitution of Cys for Arg at position 519 of the type II collagen triple helix is a predisposing factor in the pathogenesis of a precocious-onset form of familial osteoarthritis associated with a mild chondrodysplasia. Cartilage obtained at the time of total knee replacement in ...

journal_title：Biochemical and biophysical research communications

authors： Holderbaum D,Malemud CJ,Moskowitz RW,Haqqi TM

更新日期：1993-05-14 00:00:00

abstract：:Phyllanthus niruri is used in herbal medicine for treatment of diabetes. The objective of this study was to investigate the antidiabetic potential of P. niruri, using assays for α-glucosidase, muscle glucose transport, liver glucose production and adipogenesis. α-Glucosidase inhibitory activity was performed on aqueou...

journal_title：Biochemical and biophysical research communications

authors： Najari Beidokhti M,Andersen MV,Eid HM,Sanchez Villavicencio ML,Staerk D,Haddad PS,Jäger AK

更新日期：2017-11-04 00:00:00

abstract：:We investigated the genomic organization of pancreatic zymogen granule membrane-associated protein GP2, a GPI-anchored protein exhibiting self-aggregation at acidic pH, in order to construct a gene-knockout mouse. Cloning and analysis of lambda clones encoding GP2 from 129 Svj mouse genomic DNA libraries showed that t...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi K,Yanagihara K,Ishiguro K,Fukuoka S

更新日期：2004-09-17 00:00:00

abstract：:We address the question-can we use experimental design methods to investigate peptide conformation and identify conformational parameters that may contribute more significantly to the potential energy than others? We used mutually orthogonal Latin square design to sample the conformational space of peptides and analys...

journal_title：Biochemical and biophysical research communications

authors： Vengadesan K,Anbupalam T,Gautham N

更新日期：2004-04-09 00:00:00

abstract：:Changes in the intermediate filament composition of rat kidney proximal tubule cells in culture have been investigated. The data suggest that differentiated tubular epithelial cells do not express vimentin, but vimentin expression is induced when the cells begin to proliferate in culture. The cultured cells are positi...

journal_title：Biochemical and biophysical research communications

authors： Hatzinger PB,Chen Q,Dong LQ,Stevens JL

更新日期：1988-12-30 00:00:00

abstract：:Hepatocyte growth factor (HGF), originally identified as a potent mitogen for mature parenchymal hepatocytes, is a hepatotrophic factor involved in liver regeneration and is even essential for development of the liver. We report here that human recombinant HGF at a very low concentration and given intraportaly stimula...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi Y,Hamanoue M,Ueno S,Aikou T,Tanabe G,Mitsue S,Matsumoto K,Nakamura T

更新日期：1996-03-07 00:00:00

abstract：:Vertebrate homeobox genes have been identified on the basis of sequence homology to Drosophila segmentation and homeotic genes. We have analyzed the spatial distribution patterns in hatching larvae of transcripts from two different types of zebrafish (Brachydanio rerio) homeobox genes. Tritiated DNA fragments from one...

journal_title：Biochemical and biophysical research communications

authors： Njølstad PR,Fjose A

更新日期：1988-12-15 00:00:00

abstract：:When small amounts (1 microgram) of lipopolysaccharide (LPS) purified from Salmonella minnesota (SM) wild, SM R60 and SM R345 were intravenously injected into mice 7 days after heat-killed Propionibacterium acnes was intravenously injected, massive hepatic cell necrosis was induced and most of the mice died within 24 ...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi Y,Sakagami Y,Kuboi H,Kobayashi K,Yano I

更新日期：1988-09-30 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on the cell death induced by endoplasmic reticulum (ER) stress agents in RAW 264.7 cells was studied. LPS prevented the cell death by brefeldin A, but not thapsigargin and tunicamycin. CpG DNA as well as LPS prevented brefeldin A-induced cell death whereas tumor necrosis factor-a...

journal_title：Biochemical and biophysical research communications

authors： Islam S,Hassan F,Tumurkhuu G,Ito H,Koide N,Mori I,Yoshida T,Yokochi T

更新日期：2006-02-10 00:00:00

abstract：:Pathways formed of delocalized π-electron systems and polar groups of polypeptide chains bridged by hydrogen bonds are referred as π-H pathways. Suitable for electron transfer, these pathways in cytochrome c oxidase connect CuA, the source of electrons distributed in cytochrome c oxidase, with the metal centers, heme ...

journal_title：Biochemical and biophysical research communications

authors： Ramasarma T,Vaigundan D

更新日期：2019-03-05 00:00:00

abstract：:Endothelin tightly bound to rabbit aortic strips and caused a prolonged vasoconstriction both in the presence and absence of extracellular Ca2+, although only partial constriction (20-30%) developed in the latter case, indicating that its action may not be limited to the opening of a calcium channel. The endothelin-in...

journal_title：Biochemical and biophysical research communications

authors： Sugiura M,Inagami T,Hare GM,Johns JA

更新日期：1989-01-16 00:00:00

abstract：:GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell li...

journal_title：Biochemical and biophysical research communications

authors： Okitsu Y,Takahashi S,Minegishi N,Kameoka J,Kaku M,Yamamoto M,Sasaki T,Harigae H

更新日期：2007-12-14 00:00:00

abstract：:Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), protea...

journal_title：Biochemical and biophysical research communications

authors： Levano KS,Jung EH,Kenny PA

更新日期：2011-07-22 00:00:00

abstract：:6-Hydroxydopamine(6-OHDA), a specific neurotoxin against sympathetic nerve cells, is a drug already used for purging of bone marrow from neuroblastoma cells before autologous bone marrow transplantation. However, we could not detect significant differences in the toxicity of 6-OHDA against neuroblastoma and other tumo...

journal_title：Biochemical and biophysical research communications

authors： Bruchelt G,Buck J,Girgert R,Treuner J,Niethammer D

更新日期：1985-07-16 00:00:00

abstract：:When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing acti...

journal_title：Biochemical and biophysical research communications

authors： Hiro D,Ito A,Matsuta K,Mori Y

更新日期：1986-10-30 00:00:00

abstract：:Bile acids have emerged as a new class of signaling molecules that play a role in metabolism. Studies in mice have shown that the bile acid receptor TGR5 mediates several of these effects but the metabolic function of TGR5 in humans is less well established. Here we show that human adipose tissue TGR5 expression is po...

journal_title：Biochemical and biophysical research communications

authors： Svensson PA,Olsson M,Andersson-Assarsson JC,Taube M,Pereira MJ,Froguel P,Jacobson P

更新日期：2013-04-19 00:00:00