The role of reactive oxygen compounds derived from 6-hydroxydopamine for bone marrow purging from neuroblastoma cells.

abstract：:The preferred dye binding sites and the microenvironment of known nucleotide sequences within mitochondrial and plasmid pBR322 DNA was probed in a gross fashion with restriction endonucleases. The intercalating dyes, ethidium bromide and propidium iodide, do not inhibit a given restriction endonuclease equally at all ...

journal_title：Biochemical and biophysical research communications

authors： Soslau G,Pirollo K

更新日期：1983-09-15 00:00:00

abstract：:Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence. Acetylcholine and methacholine were full and potent agonists, while carbachol and muscarine, were fully efficacious but 6- and 10-fold less potent than acetylcholine. The carb...

journal_title：Biochemical and biophysical research communications

authors： Noronha-Blob L,Richard C,U'Prichard DC

更新日期：1987-08-31 00:00:00

abstract：:Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Unfortunately, the mechani...

journal_title：Biochemical and biophysical research communications

authors： Hong X,Li S,Li W,Xie M,Wei Z,Guo H,Wei W,Zhang S

更新日期：2019-01-15 00:00:00

abstract：:Osteoblasts regulate bone formation and remodeling, and are main target cells of oxidative stress in the progression of osteonecrosis. The stem cell factor (SCF)-c-Kit pathway plays important roles in the proliferation, differentiation and survival in a range of cell types, but little is known about its functions in o...

journal_title：Biochemical and biophysical research communications

authors： Yang L,Wu Z,Yin G,Liu H,Guan X,Zhao X,Wang J,Zhu J

更新日期：2014-12-12 00:00:00

abstract：:T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive to ponatinib (PNT). However, the novel strategy is required to reduce life-threatening adverse effects of PNT including i...

journal_title：Biochemical and biophysical research communications

authors： Inoue C,Sobue S,Kawamoto Y,Nishizawa Y,Ichihara M,Abe A,Hayakawa F,Suzuki M,Nozawa Y,Murate T

更新日期：2020-05-14 00:00:00

abstract：:Syntaxins are a family of membrane proteins believed to participate in docking/fusing of arriving vesicles during membrane sorting and secretion. Of the six mammalian syntaxins known, only brain syntaxin 1A/1B has been biochemically characterized in its endogenous form. Syntaxin 4 mRNA is expressed in selective tissue...

journal_title：Biochemical and biophysical research communications

authors： Sumitani S,Ramlal T,Liu Z,Klip A

更新日期：1995-08-15 00:00:00

abstract：:Vibrio cholerae cytolysin (VCC), a β-barrel pore-forming toxin (β-PFT), induces killing of the target eukaryotic cells by forming heptameric transmembrane β-barrel pores. Consistent with the β-PFT mode of action, binding of the VCC toxin monomers with the target cell membrane triggers formation of pre-pore oligomeric ...

journal_title：Biochemical and biophysical research communications

authors： Paul K,Chattopadhyay K

更新日期：2014-01-03 00:00:00

abstract：:We isolated mouse CPP32/apopain cDNA, a mammalian homologue most closely related to Ced-3 in C. elegans, and examined the involvement of CPP32 in the apoptosis of nervous system during development. CPP32 is specifically expressed in the trigeminal (V) ganglia, facio-acoustic (VII-VIII) ganglion complex, and dorsal roo...

journal_title：Biochemical and biophysical research communications

authors： Mukasa T,Urase K,Momoi MY,Kimura I,Momoi T

更新日期：1997-02-24 00:00:00

abstract：:Individual yeast colonies produce pulses of volatile ammonia separated by phases of medium acidification. Colonies of Saccharomyces cerevisiae mutant defective in the general amino acid permease, Gap1p, exhibit decreased ammonia production. Mutations in the S. cerevisiae amino acid sensor SPS completely abolish the co...

journal_title：Biochemical and biophysical research communications

authors： Zikánová B,Kuthan M,Ricicová M,Forstová J,Palková Z

更新日期：2002-06-28 00:00:00

abstract：:Gonadotropin releasing hormone is a hypothalamic decapeptide that stimulates the release of gonadotropic hormones from the anterior pituitary gland. Therapeutically, the human pituitary GnRH receptor is the target of agonists used in the suppression of prostate cancer. Here we report the isolation of a cDNA representi...

journal_title：Biochemical and biophysical research communications

authors： Kakar SS,Musgrove LC,Devor DC,Sellers JC,Neill JD

更新日期：1992-11-30 00:00:00

abstract：:Multidrug resistance protein 1 (MRP1) is a member of the ATP-binding cassette superfamily. Using the energy provided by ATP hydrolysis, it transports a broad spectrum of substrates across the plasma membrane, including hormones, leukotriene C(4), bile salts, and anti-cancer drugs. Recent works have suggested that P-gl...

journal_title：Biochemical and biophysical research communications

authors： Cerf E,Gasper R,Belani JD,Rychnovsky S,Chang XB,Buyse F,Ruysschaert JM

更新日期：2007-04-20 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various normal and neoplastic tissues. Even if the physiological function(s) of PTHrP is unclear, evidence suggests that the protein may participate in the local regulation of smooth muscle contractility. We show here that PTHrP is produced in endothelial cell...

journal_title：Biochemical and biophysical research communications

authors： Rian E,Jemtland R,Olstad OK,Endresen MJ,Grasser WA,Thiede MA,Henriksen T,Bucht E,Gautvik KM

更新日期：1994-01-28 00:00:00

abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

journal_title：Biochemical and biophysical research communications

authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

更新日期：1994-09-30 00:00:00

abstract：:Lysates of rabbit reticulocytes and other mammalian cells are known to contain an activity which binds with high specificity ppp(A2'p)3A,3'-[32P]pCp. The binding activity shows a marked dependence on preincubation of lysates at different temperatures (4 degrees C - 45 degrees C). For example, binding was increased 50%...

journal_title：Biochemical and biophysical research communications

authors： Wu JM,Eslami B,Semproni AR

更新日期：1983-11-30 00:00:00

abstract：:PP2Cgamma is a splicing factor that dephosphorylates specific substrates required for the formation of the spliceosome. In a previous study, we reported that the degradation of p21(Cip1/WAF1)was affected by PP2Cgamma, causing an accumulation of cells in S phase. Here, we demonstrate that the PP2Cgamma-induced degradat...

journal_title：Biochemical and biophysical research communications

authors： Suh EJ,Kim YJ,Kim SH

更新日期：2009-08-28 00:00:00

abstract：:Sepiapterin reductase (SPR) is an enzyme that acts in the third and final step of tetrahydrobiopterin (BH4) biosynthesis. The human Spr gene locates within the region of 2.5MB mapped to PARK3, an autosomal dominant form of familial Parkinson's diseases. In order to explore the role of SPR in the metabolism of BH4, we ...

journal_title：Biochemical and biophysical research communications

authors： Takazawa C,Fujimoto K,Homma D,Sumi-Ichinose C,Nomura T,Ichinose H,Katoh S

更新日期：2008-03-21 00:00:00

abstract：:The nonsense-mediated decay (NMD) pathway selectively degrades mRNAs carrying a premature translation-termination codon but also regulates the abundance of a large number of physiological mRNAs that encode full-length proteins. In human cells, NMD-targeted mRNAs are degraded by endonucleolytic cleavage and exonucleoly...

journal_title：Biochemical and biophysical research communications

authors： da Costa PJ,Menezes J,Saramago M,García-Moreno JF,Santos HA,Gama-Carvalho M,Arraiano CM,Viegas SC,Romão L

更新日期：2019-10-22 00:00:00

abstract：:Receptor content in cultured kidney (LLC-PK1) cells was found to be modulated following the introduction of a culture medium change, declining to 40% of control values at 18 h. Scatchard analysis indicated that the reduced 1,25(OH)2-[3H]D3 nuclear binding we detected was due to decreased abundance of receptors (3811 v...

journal_title：Biochemical and biophysical research communications

authors： Hirst M,Feldman D

更新日期：1983-10-14 00:00:00

abstract：:Histone chaperones function in histone transfer and regulate the nucleosome occupancy and the activity of genes. HIRA is a replication-independent (RI) histone chaperone that is linked to transcription and various developmental processes. Here, we show that HIRA interacts with Mef2 and contributes to the activation of...

journal_title：Biochemical and biophysical research communications

authors： Yang JH,Choi JH,Jang H,Park JY,Han JW,Youn HD,Cho EJ

更新日期：2011-04-15 00:00:00

abstract：:Group II chaperonins (Cpns) are essential mediators of cellular protein folding in eukaryotes and archaea. They consist of two back-to-back rings forming symmetrical cavities in which non-native substrates undergo appropriate folding, but the primary structural basis for the double ring formation remains unclear. To a...

journal_title：Biochemical and biophysical research communications

authors： Luo H,Zhang P,Robb FT

更新日期：2011-09-23 00:00:00

abstract：:Tau plays important roles in the assembly and stabilization of the microtubule structure to facilitate axonal transport in mammalian brain. The intracellular tau aggregates to form paired helical filaments leading to neurodegenerative disorders, collectively called tauopathies. In our previous report, we established a...

journal_title：Biochemical and biophysical research communications

authors： Wu BK,Yuan RY,Chang YP,Lien HW,Chen TS,Chien HC,Tong TS,Tsai HP,Fang CL,Liao YF,Chang CC,Chen RP,Huang CJ

更新日期：2016-08-19 00:00:00

abstract：:MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cel...

journal_title：Biochemical and biophysical research communications

authors： Zhang WW,Tong HL,Sun XF,Hu Q,Yang Y,Li SF,Yan YQ,Li GP

更新日期：2015-08-07 00:00:00

abstract：:Dual-excitation ratiometric dyes permit quantitative Ca2+ measurements by minimizing the effects of several artifacts that are unrelated to changes in the concentration of free Ca2+ ([Ca2+]). These dyes are excited alternately at two different wavelengths, and the pair of intensity measurements must be collected seque...

journal_title：Biochemical and biophysical research communications

authors： Fukano T,Shimozono S,Miyawaki A

更新日期：2004-04-23 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (LncRNAs) show dysregulation in a variety of cancers. However, the function and specific mechanism of LncRNA GSEC in the progression of osteosarcoma remain mostly unknown. In this study, we sought to elucidate the role and mechanism of LncRNA GSEC in the occurrence and progression of oste...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Ju C,Zhang F,Tang X,Yan J,Sun J,Lv B,Guo Y,Liang Y,Lv XB,Zhang Z

更新日期：2020-11-05 00:00:00

abstract：:Although mutations and deletions in the p53 tumor suppressor gene lead to resistance to low linear energy transfer (LET) radiation, high-LET radiation efficiently induces cell lethality and apoptosis regardless of the p53 gene status in cancer cells. Recently, it has been suggested that the induction of p53-independen...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa Y,Takahashi A,Kajihara A,Yamakawa N,Imai Y,Ota I,Okamoto N,Mori E,Noda T,Furusawa Y,Kirita T,Ohnishi T

更新日期：2012-07-13 00:00:00

abstract：:Transgenic (TG) mice expressing porcine GH receptor (pGHR) directed by a 762-bp proximal leptin promoter were used to analyze the capability of the promoter to drive and regulate pGHR expression in vivo. Transgene expression occurred in inguinal, retroperitoneal, and epididymal/parametrial fat depots in both male and ...

journal_title：Biochemical and biophysical research communications

authors： Chen XL,Hartzell DL,McGraw RA,Hausman GJ,Dean RG

更新日期：1999-08-19 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Although cytotoxicity of amyloid β peptides has been intensively studied within pathophysiology of AD, the physiological function of amyloid precursor protein (APP) still remains unclarified. We have shown previously tha...

journal_title：Biochemical and biophysical research communications

authors： Kwak YD,Hendrix BJ,Sugaya K

更新日期：2014-05-09 00:00:00

abstract：:Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor ...

journal_title：Biochemical and biophysical research communications

authors： Mitchell MD,Lytton FD,Varticovski L

更新日期：1988-02-29 00:00:00

abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

journal_title：Biochemical and biophysical research communications

authors： Cai T,Lei QY,Wang LY,Zha XL

更新日期：2000-08-02 00:00:00

abstract：:Cell membranes are vitally important to living cells. Although the infrastructure of biological membrane is provided by the lipid bilayer, membrane proteins perform most of the specific functions. Knowledge of membrane protein types often provides crucial hints toward determining the function of an uncharacterized mem...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Wang M,Chou KC

更新日期：2005-10-28 00:00:00