Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.

abstract：:The repair-associated gene XRCC1 was previously cloned by complementing the hamster mutant EM9, which has a high rate of spontaneous SCE and hypersensitivity to DNA damaging agents. In analyzing XRCC1 gene expression, similar levels of steady-state mRNA were found in normal cells, Bloom's syndrome cells with altered S...

journal_title：Biochemical and biophysical research communications

authors： Yoo H,Li L,Sacks PG,Thompson LH,Becker FF,Chan JY

更新日期：1992-07-31 00:00:00

abstract：:Normal human serum transferrin is present in several isoforms, due to differences in glycosylation. Transferrin has two potential glycosylation sites, both normally occupied by oligosaccharide chains. Two of the transferrin isoforms, called carbohydrate deficient transferrin, are specifically increased in patients wit...

journal_title：Biochemical and biophysical research communications

authors： Landberg E,Påhlsson P,Lundblad A,Arnetorp A,Jeppsson JO

更新日期：1995-05-16 00:00:00

abstract：:The ocr protein of bacteriophage T7 is a structural and electrostatic mimic of approximately 24 base pairs of double-stranded B-form DNA. As such, it inhibits all Type I restriction and modification (R/M) enzymes by blocking their DNA binding grooves and inactivates them. This allows the infection of the bacterial cel...

journal_title：Biochemical and biophysical research communications

authors： Stephanou AS,Roberts GA,Tock MR,Pritchard EH,Turkington R,Nutley M,Cooper A,Dryden DT

更新日期：2009-01-02 00:00:00

abstract：:The regulation of the expression of three Escherichia coli met genes, metB, which codes for cystathionine gamma-synthetase (EC 4.2.99.9), metL, which codes for aspartokinase II-homoserine dehydrogenase II (EC 2.7.2.4-EC 1.1.1.3) and metJ, which codes for the methionine regulon aporepressor, has been studied using high...

journal_title：Biochemical and biophysical research communications

authors： Shoeman R,Coleman T,Redfield B,Greene RC,Smith AA,Saint-Girons I,Brot N,Weissbach H

更新日期：1985-12-17 00:00:00

abstract：:Bacteria belonging to the Burkholderia cepacia complex (BCC) are important opportunistic pathogens in patients with cystic fibrosis (CF). Since approximately 80% of the CF isolates examined produce exopolysaccharide (EPS), it was hypothesized that this EPS may play a role in the colonization and persistence of these b...

journal_title：Biochemical and biophysical research communications

authors： Moreira LM,Videira PA,Sousa SA,Leitão JH,Cunha MV,Sá-Correia I

更新日期：2003-12-12 00:00:00

abstract：:The regulatory mechanisms of most cyclin dependent protein kinases (CDKs) are well understood and are highly conserved in eukaryotes. CDKs from the malaria parasite, Plasmodium falciparum, appear to be regulated in a similar manner with regard to cyclin binding and phosphorylation. In order to further understand their...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Le Roch K,Geyer JA,Woodard CL,Prigge ST,Koh J,Doerig C,Waters NC

更新日期：2001-11-16 00:00:00

abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

journal_title：Biochemical and biophysical research communications

authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

更新日期：2017-06-17 00:00:00

abstract：:The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agoni...

journal_title：Biochemical and biophysical research communications

authors： Sitaula S,Billon C,Kamenecka TM,Solt LA,Burris TP

更新日期：2015-05-08 00:00:00

abstract：:In order to study the role of phosphatidylinositol-3-kinase (PI3K) in insulin action, we employed a specific inhibitor of PI3K, LY294002, and measured five biological functions of insulin in mouse 3T3 fibroblasts overexpressing human insulin receptors. LY294002 had no effect on tyrosine phosphorylation of both the ins...

journal_title：Biochemical and biophysical research communications

authors： Sanchez-Margálet V,Goldfine ID,Vlahos CJ,Sung CK

更新日期：1994-10-28 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:GGAs (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor (ARF)-binding proteins), constitute a family of monomeric adaptor proteins and are associated with protein trafficking from the trans-Golgi network to endosomes. Here, we show that GGA3 is monoubiquitylated by a RING-H2 type-ubiquitin l...

journal_title：Biochemical and biophysical research communications

authors： Yogosawa S,Kawasaki M,Wakatsuki S,Kominami E,Shiba Y,Nakayama K,Kohsaka S,Akazawa C

更新日期：2006-11-10 00:00:00

abstract：:Accumulating evidence demonstrates that aldosterone can cause extra-cellular matrix (ECM) accumulation, in addition to regulating sodium and potassium homeostasis. Increased extra-cellular matrix production by renal glomerular mesangial cells has been suggested to be involved in pathogenesis of glomerular sclerosis. T...

journal_title：Biochemical and biophysical research communications

authors： Lai L,Chen J,Hao CM,Lin S,Gu Y

更新日期：2006-09-15 00:00:00

abstract：:Several lines of evidence provided by other workers indicate that within the same species thyroid hormone binding protein, the beta-subunit of prolyl hydroxylase, and protein disulfide isomerase are the same protein. We sought to determine if glycosylation site binding protein, a lumenal protein of the endoplasmic ret...

journal_title：Biochemical and biophysical research communications

authors： Kimura H,Noiva R,Mizunaga T,Yamauchi K,Horiuchi R,Cheng SY,Lennarz WJ

更新日期：1990-08-16 00:00:00

abstract：:(1S,5S,6R,7R)-7-Chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714), a novel cyclic amidine analogue, inhibits human inducible nitric oxide (iNOS) with a K(i) of 1.88 nM and rodent iNOS with similar potency in vitro. ONO-1714 was found to be 10-fold selective for human iNOS over human endotheli...

journal_title：Biochemical and biophysical research communications

authors： Naka M,Nanbu T,Kobayashi K,Kamanaka Y,Komeno M,Yanase R,Fukutomi T,Fujimura S,Seo HG,Fujiwara N,Ohuchida S,Suzuki K,Kondo K,Taniguchi N

更新日期：2000-04-13 00:00:00

abstract：:Interleukin 1 alpha (IL-1) and tumor necrosis factor alpha (TNF) are two monokines which play a prominent role in the response to inflammation and injury. We recently observed that TNF leads to an increase in the synthesis of the heavy chain of ferritin, suggesting that TNF may be involved in iron homeostasis (Torti e...

journal_title：Biochemical and biophysical research communications

authors： Wei Y,Miller SC,Tsuji Y,Torti SV,Torti FM

更新日期：1990-05-31 00:00:00

abstract：:Vitronectin immobilized onto polystyrene microtiter wells was demonstrated to specifically bind plasminogen in a concentration-dependent manner, yielding an estimated KD = 0.4 microM. Heparin only moderately interfered with the vitronectin-plasminogen interaction, whereas high concentrations of 6-amino-hexanoic acid i...

journal_title：Biochemical and biophysical research communications

authors： Preissner KT

更新日期：1990-05-16 00:00:00

abstract：:The natural compound ferulenol, a sesquiterpene prenylated coumarin derivative, was purified from Ferula vesceritensis and its mitochondrial effects were studied. Ferulenol caused inhibition of oxidative phoshorylation. At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide tr...

journal_title：Biochemical and biophysical research communications

authors： Lahouel M,Zini R,Zellagui A,Rhouati S,Carrupt PA,Morin D

更新日期：2007-03-30 00:00:00

abstract：:S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regul...

journal_title：Biochemical and biophysical research communications

authors： Lee Y,Jang S,Min JK,Lee K,Sohn KC,Lim JS,Im M,Lee HE,Seo YJ,Kim CD,Lee JH

更新日期：2012-07-13 00:00:00

abstract：:Several studies support a role for the multiple tumor suppressor gene (MTS1) in the malignant progression of different tumor types. In this study we have examined the status of the MTS1 gene in a variety of non-astrocytic tumors of the central nervous system. It was not possible, using multiplex PCR with primers for M...

journal_title：Biochemical and biophysical research communications

authors： Walker DG,Duan W,Kaye AH,Lavin MF

更新日期：1995-06-15 00:00:00

abstract：:Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of sol...

journal_title：Biochemical and biophysical research communications

authors： Guerin C,Luddy C,Abounader R,Lal B,Laterra J

更新日期：2000-06-24 00:00:00

abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

journal_title：Biochemical and biophysical research communications

authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

更新日期：1986-10-15 00:00:00

abstract：:The morphology and function of Leydig cells are changed during the development, mature and senility of Leydig cells along the life span of males. This study was to observe the growth morphology of adult mouse Leydig cells in culture, aiming to provide a reference for furthermore understanding of the biological functio...

journal_title：Biochemical and biophysical research communications

authors： Wang JQ,Cao WG

更新日期：2016-01-22 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:Calmodulin contains multiple redox sensitive methionines whose oxidation alters the regulation of numerous targets. Molecular dynamics simulations were used to define the molecular principles that govern how calmodulin is structurally poised to detect and respond to methionine oxidation. We found that calmodulin's ope...

journal_title：Biochemical and biophysical research communications

authors： Walgenbach DG,Gregory AJ,Klein JC

更新日期：2018-10-20 00:00:00

abstract：:Glutamate receptor delta2 (GluD2) is selectively expressed on the postsynaptic spines at parallel-fiber (PF)-Purkinje neuron (PN) synapses. GluD2 knockout mice show a reduced number of PF-PN synapses, suggesting that GluD2 is involved in synapse formation. Recent studies revealed that GluD2 induces presynaptic differe...

journal_title：Biochemical and biophysical research communications

authors： Kuroyanagi T,Hirano T

更新日期：2010-07-30 00:00:00

abstract：:Tau misfolding has been implicated in a variety of tauopathies, including Alzheimer's disease. The microtubule binding domain of tau consists of four repeat segments (R1-R4), and aggregation of these segments leads to the formation of neurofibrillary tangles. Previous studies indicate that misfolded tau associates wit...

journal_title：Biochemical and biophysical research communications

authors： Dicke SS,Tatge L,Engen PE,Culp M,Masterson LR

更新日期：2017-12-02 00:00:00

abstract：:The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling...

journal_title：Biochemical and biophysical research communications

authors： Kuo HP,Lee DF,Xia W,Wei Y,Hung MC

更新日期：2009-11-27 00:00:00

abstract：:Thick filaments from some striated muscles are regulated by phosphorylation of myosin regulatory light chains (RLCs). A tarantula thick filament quasi-atomic model achieved by cryo-electron microscopy has advanced our understanding on how this regulation occurs. In native thick filaments, an asymmetric intramolecular ...

journal_title：Biochemical and biophysical research communications

authors： Sulbarán G,Biasutto A,Méndez F,Pinto A,Alamo L,Padrón R

更新日期：2020-03-26 00:00:00

abstract：:Lipopolysaccharide (LPS) is the main component of Gram-negative bacteria that - upon infection - activates the host immune system and is crucial in fighting pathogens as well as in the induction of sepsis. In the present study we addressed the question whether the key structural components of LPS equally take part in ...

journal_title：Biochemical and biophysical research communications

authors： Eder K,Vizler C,Kusz E,Karcagi I,Glavinas H,Balogh GE,Vigh L,Duda E,Gyorfy Z

更新日期：2009-11-06 00:00:00

abstract：:Recognition of oligodeoxynucleotides containing CpG motifs (CpG-ODNs) by toll-like receptor 9 (TLR9) inhibits RANKL-induced osteoclastogenesis from precursors. This inhibitory effect suggests the possibility of using this strategy to block pathological bone loss. However, the enhancing effect of CpG-ODNs on OC formati...

journal_title：Biochemical and biophysical research communications

authors： Chang JH,Chang EJ,Kim HH,Kim SK

更新日期：2009-11-06 00:00:00