Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.

abstract：:The effects of arachidonic acid on the enzyme complexes in the electron transport system were investigated using submitochondrial particles from rat brain. Arachidonic acid irreversibly inhibited NADH-CoQ oxidoreductase (complex I) activity, but had no effect on the activities of succinate-CoQ oxidoreductase (complex ...

journal_title：Biochemical and biophysical research communications

authors： Morii H,Takeuchi Y,Watanabe Y

更新日期：1991-08-15 00:00:00

abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

journal_title：Biochemical and biophysical research communications

authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

更新日期：2015-11-27 00:00:00

abstract：:We previously demonstrated that pleiotrophin (PTN the protein, Ptn the gene) highly regulates the levels of expression of the genes encoding the proteins of the renin-angiotensin pathway in mouse aorta. We now demonstrate that the levels of expression of these same genes are significantly regulated in mouse aorta by t...

journal_title：Biochemical and biophysical research communications

authors： Ezquerra L,Herradon G,Nguyen T,Silos-Santiago I,Deuel TF

更新日期：2005-07-29 00:00:00

abstract：:Cancer chemotherapy with taxol often fails due to acquired resistance of cancer cells, which is frequently associated with an overexpression of P-gp and alterations of beta-tubulin. A taxol-resistant cell line, QGY-TR50, derived from a human hepatocellular carcinoma (HCC) QGY-7703 cell line was used to investigate the...

journal_title：Biochemical and biophysical research communications

authors： Zhou J,Cheng SC,Luo D,Xie Y

更新日期：2001-02-09 00:00:00

abstract：:Malondialdehyde measurements have been the major tool for studying relationships between lipid peroxidation and tissue pathology. Recently, we presented a novel gas chromatography-mass spectrometry method for direct detection of phospholipid peroxides with picogram sensitivity based on transesterification of phospholi...

journal_title：Biochemical and biophysical research communications

authors： van Kuijk FJ,Thomas DW,Stephens RJ,Dratz EA

更新日期：1986-08-29 00:00:00

abstract：:In the course of the eukaryotic ribosomal biogenesis, both the nuclear import and export are involved. We have studied the nuclear and nucleolar localization of the human ribosomal protein S7. We examined the subcellular distribution of the S7:beta-galactosidase fusion protein in SAOS-2 cells. We have identified two e...

journal_title：Biochemical and biophysical research communications

authors： Annilo T,Karis A,Hoth S,Rikk T,Kruppa J,Metspalu A

更新日期：1998-08-28 00:00:00

abstract：:Chemotherapeutic efficacy is also regulated by the tumor microenvironment. IL-6 produced by TAMs and downstream IL-6/STAT3 signaling pathway is central regulator in chemotherapeutic response. The M2-like phenotype of TAMs is characterized by elevated iron uptake. Whether iron participates in chemo-resistance need to b...

journal_title：Biochemical and biophysical research communications

authors： Li J,He K,Liu P,Xu LX

更新日期：2016-06-24 00:00:00

abstract：:XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification o...

journal_title：Biochemical and biophysical research communications

authors： Yin W,Cheepala S,Clifford JL

更新日期：2006-01-27 00:00:00

abstract：:Endothelin-like immunoreactivity (-LI) was detected in the kidney, spleen, skeletal muscle, lung and in plasma of the pig. The highest tissue levels were found in the lung (1.5 +/- 0.07 pmol/g) and the lowest in the muscle (0.08 +/- 0.02 pmol/g). I.v. infusion of endothelin (20 pmol/kg/min for 20 min) increased plasma...

journal_title：Biochemical and biophysical research communications

authors： Pernow J,Hemsén A,Lundberg JM

更新日期：1989-06-15 00:00:00

abstract：:Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that...

journal_title：Biochemical and biophysical research communications

authors： Whitson RH,Tsark W,Huang TH,Itakura K

更新日期：2003-12-26 00:00:00

abstract：:The thromboxane receptor has two alternatively spliced isoforms, alpha and beta, which differ only in sequences within the cytoplasmic C-terminal domain. Oxidative stress induced by H(2)O(2) in a COS-7 cell model results in stabilization of the thromboxane receptor beta isoform by translocation from the endoplasmic re...

journal_title：Biochemical and biophysical research communications

authors： Valentin F,Tippins JR,Field MC

更新日期：2005-04-15 00:00:00

abstract：:A biotin-polyethylene glycol (PEG)-epidermal growth factor (EGF) conjugate was immobilized onto the surface of avidin-modified adenovirus (ADV-Avi) via biotin-avidin interaction to deliver ADV specifically to EGF receptor over-expressing cancer cells. ADV-Avi/biotin-PEG-EGF complexes showed greatly enhanced intracellu...

journal_title：Biochemical and biophysical research communications

authors： Park JW,Mok H,Park TG

更新日期：2008-02-15 00:00:00

abstract：:It has long been assumed that Ca2+ are translocated from the cytosol to the cell nucleus by a long distance to activate transcription machinery buried deep in the nucleoplasm. However, this model has been recently challenged. When HeLa cells were loaded with fluo-3, highly fluorescent spots of approximately 2 microns ...

journal_title：Biochemical and biophysical research communications

authors： Lui PP,Kong SK,Kwok TT,Lee CY

更新日期：1998-06-09 00:00:00

abstract：:In this study, we demonstrate that in addition to T lymphocytes, human naïve eosinophils and the differentiated eosinophil-like cell line, AML14.3D10 express CCR8 and respond to CCL1 through CCR8 engagement. The responsiveness of cells was dependent on maturation stage, since CCL1 induced pronounced chemotaxis only in...

journal_title：Biochemical and biophysical research communications

authors： Karlsson AK,Walles K,Bladh H,Connolly S,Skrinjar M,Rosendahl A

更新日期：2011-04-22 00:00:00

abstract：:We have isolated a new recombinant antigen 'PV12' of Plasmodium vivax by immunological screening of the genomic library. The antigen shows a sequence homology with human apolipoprotein B-100. A large number of P. vivax infected individuals (79%) were seropositive against this antigen. The probable function of this ant...

journal_title：Biochemical and biophysical research communications

authors： Ray P,Sharma YD

更新日期：1992-04-30 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:Nischarin, a novel integrin binding protein, has been demonstrated its negative effects on cell migration and invasion. However, the biological role of Nischarin in breast cancer has not been fully elucidated yet. Our study aimed to analyze the association between Nischarin expression and clinical features of breast c...

journal_title：Biochemical and biophysical research communications

authors： Chang C,Wei W,Han D,Meng J,Zhu F,Xiao Y,Wu G,Shi X,Zhang L

更新日期：2017-03-11 00:00:00

abstract：:Neuropathic pain is triggered by damage to or as a result of the dysfunction of the somatosensory nervous system. Gene expression profiling using DNA microarray and real-time PCR have emerged as powerful tools for the elucidation of pain-specific pathways and identification of candidate biomarkers and therapeutic targ...

journal_title：Biochemical and biophysical research communications

authors： Wan G,Yang K,Lim Q',Zhou L,He BP,Wong HK,Too HP

更新日期：2010-10-01 00:00:00

abstract：:During IFN alpha stimulation, p59(fyn) associates with the Type I IFNR-associated Tyk-2 kinase in several human hematopoietic cell lines in vivo. This interaction is direct, and is mediated by the SH2 domain in p59(fyn), as shown by binding studies using glutathione-S-transferase fusion proteins and far western blots....

journal_title：Biochemical and biophysical research communications

authors： Uddin S,Sher DA,Alsayed Y,Pons S,Colamonici OR,Fish EN,White MF,Platanias LC

更新日期：1997-06-09 00:00:00

abstract：:Recent works have shown that mechanical loading can alter the metabolic activity of chondrocytes cultured in 3D scaffolds. In this study we determined whether the stage of development of engineered cartilaginous constructs (expanded adult human articular chondrocytes/Polyactive foams) regulates the effect of dynamic c...

journal_title：Biochemical and biophysical research communications

authors： Démarteau O,Wendt D,Braccini A,Jakob M,Schäfer D,Heberer M,Martin I

更新日期：2003-10-17 00:00:00

abstract：:Recently a rabbit cDNA (F3R) was characterized as binding and causing calcium mobilization induced by the formyl-methionine-leucine-phenylalanine peptide (fMLP). In the study reported here, cloned DNAs were isolated from rabbit genomic DNA by PCR based on the sequence of F3R. The cloned DNAs have several differences i...

journal_title：Biochemical and biophysical research communications

authors： Beckmann MP,Munger WE,Kozlosky C,VandenBos T,Price V,Lyman S,Gerard NP,Gerard C,Cerretti DP

更新日期：1991-09-16 00:00:00

abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

更新日期：2017-12-09 00:00:00

abstract：:Many amplified-chromosome regions in human cancers have been identified, while there are only a limited number of reports for amplified genes in a single amplicon. We recently isolated four cDNA clones, A39, B47, C51, and CAB1, from 500 kilobases of yeast artificial chromosome DNA containing the c-ERBB-2 gene. B47 con...

journal_title：Biochemical and biophysical research communications

authors： Kishi T,Sasaki H,Akiyama N,Ishizuka T,Sakamoto H,Aizawa S,Sugimura T,Terada M

更新日期：1997-03-06 00:00:00

abstract：:The role of heteromeric phosphoinositide (PI) 3-kinase activity in insulin signal transduction was studied by investigating the effects of (i) overexpression of a dominant negative mutant p85 (delta p85) that lacks the binding site for p110 (delta p85-overexpressing cells) and (ii) inhibition of PI 3-kinase activity b...

journal_title：Biochemical and biophysical research communications

authors： Hara K,Yonezawa K,Sakaue H,Kotani K,Kotani K,Kojima A,Waterfield MD,Kasuga M

更新日期：1995-03-17 00:00:00

abstract：:The perichromosomal layer (PCL) is a structure that surrounds mitotic chromosomes, found in both animal and plant cells. It comprises various proteins and RNAs, mainly derived from the nucleolus. Several functions for the PCL have been suggested; however, the mechanism of PCL organization during mitosis remains unclea...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Kato K,Kimura K

更新日期：2017-11-18 00:00:00

abstract：:The cAMP response element binding protein (CREB) is expressed at constitutively low levels in most cell types, and the CREB promoter possesses features that are typical of house-keeping genes. Since the CREB promoter also contains sequences which can mediate cAMP responsiveness in transfection experiments, it has been...

journal_title：Biochemical and biophysical research communications

authors： Crosson SM,Davies GF,Roesler WJ

更新日期：1996-10-23 00:00:00

abstract：:The influence of collagen as an effective substitute for gelatin was investigated on properties of chitosan/gelatin hydrogels for fibroblasts growth and attachment for wound dressing applications. We synthesized hydrogels based on chitosan associated with collagen and gelatin biopolymers (in the ratio of 1:5 and 1:1, ...

journal_title：Biochemical and biophysical research communications

authors： Mousavi S,Khoshfetrat AB,Khatami N,Ahmadian M,Rahbarghazi R

更新日期：2019-10-22 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:Thrombomodulin (TM) is a cell-surface glycoprotein and a critical mediator of endothelial anticoagulant function. TM exists as both a chondroitin sulfate (CS) proteoglycan (PG) form and a non-PG form lacking a CS chain (α-TM); therefore, TM can be described as a part-time PG. Previously, we reported that α-TM bears an...

journal_title：Biochemical and biophysical research communications

authors： Izumikawa T,Kitagawa H

更新日期：2015-05-01 00:00:00

abstract：:The alternatively spliced isoform of the nonmuscle myosin II heavy chain B (MHC-B) with an insert of 21 amino acids at the 50- to 20-kDa junction of the globular region of myosin has been demonstrated to be expressed specifically in the central nervous system (CNS) in chicken. To explore the role of this B2 inserted i...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Hirano T,Uchida K,Yamagishi A

更新日期：1999-05-27 00:00:00