Molecular cloning of rat liver glucocorticoid-receptor translocation promoter.

Abstract:

:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An open reading frame of 524 amino acids encodes a protein with a molecular weight of 57 kDa. Amino-acid sequences of six peptides obtained by Edman degradation of various cleavage products of the purified ASTP were identified in the cDNA-derived sequence. Northern analysis of mRNA from rat liver revealed a major band of about 3.8 kb. Database searches show no homology to other known proteins from mammalian origin, however, the amino-acid sequence in the middle portion of ASTP protein shows 48% homology to glycerol kinase from Escherichia coli. The region of homology to other species may help to define sites of protein-protein interaction, as well as sites of possible interaction of ASTP with ATP.

authors

Okamoto K,Hirano H,Isohashi F

doi

10.1006/bbrc.1993.1703

subject

Has Abstract

pub_date

1993-06-30 00:00:00

pages

848-54

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71703-1

journal_volume

193

pub_type

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