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Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols.

Abstract：

:Endothelin tightly bound to rabbit aortic strips and caused a prolonged vasoconstriction both in the presence and absence of extracellular Ca2+, although only partial constriction (20-30%) developed in the latter case, indicating that its action may not be limited to the opening of a calcium channel. The endothelin-induced constriction was reversed by the protein kinase C inhibitor, 1-(5-isoquinolynylsulfonyl)-2-methylpiperazine (H-7). In contrast to the observation of Hirata et al (1), endothelin caused a robust phosphatidylinositol breakdown producing inositol mono-, bis-and trisphosphates in cultured rat vascular smooth muscle cells. It showed no effect on cyclic nucleotide levels in the same cultured cells. These results indicate that phosphatidylinositol turnover and protein kinase C activation are involved in endothelin-induced vasoconstriction.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sugiura M,Inagami T,Hare GM,Johns JA

doi

10.1016/s0006-291x(89)80193-7

subject

Has Abstract

pub_date

1989-01-16 00:00:00

pages

170-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(89)80193-7

journal_volume

158

pub_type

杂志文章

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