ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.

abstract：:The MYST acetyltransferase HBO1 is implicated in the regulation of DNA replication and activities of transcription factors such as the androgen receptor. Since the androgen receptor and NF-kappaB transcription factors crossmodulate their transcriptional activity, we investigated whether HBO1 regulates NF-kappaB signal...

journal_title：Biochemical and biophysical research communications

authors： Contzler R,Regamey A,Favre B,Roger T,Hohl D,Huber M

更新日期：2006-11-10 00:00:00

abstract：:Mutual interactions between adipocytes and immune cells in white adipose tissue (WAT) are involved in modulation of lipid metabolism in the tissue and also in response to omega-3 polyunsaturated fatty acids (PUFA), which counteract adverse effects of obesity. This complex interplay depends in part on in situ formed an...

journal_title：Biochemical and biophysical research communications

authors： Kuda O,Rombaldova M,Janovska P,Flachs P,Kopecky J

更新日期：2016-01-15 00:00:00

abstract：:The cDNA encoding Mn peroxidase isozyme H4 from Phanerochaete chrysosporium was recombined into a baculovirus and heterologously expressed in Sf9 cells. The recombinant Mn peroxidase has the same molecular weight as the native enzyme as determined by SDS-PAGE and cross-reacts with a Mn peroxidase-specific antibody. Th...

journal_title：Biochemical and biophysical research communications

authors： Pease EA,Aust SD,Tien M

更新日期：1991-09-16 00:00:00

abstract：:The receptor for calcitonin gene-related peptide (CGRP) has been the target for the development of novel small molecule antagonists for the treatment of migraine. Two such antagonists, BIBN4096BS and MK-0974, have shown great promise in clinical trials and hence a deeper understanding of the mechanism of their interac...

journal_title：Biochemical and biophysical research communications

authors： Miller PS,Barwell J,Poyner DR,Wigglesworth MJ,Garland SL,Donnelly D

更新日期：2010-01-01 00:00:00

abstract：:The effects of heme on the synthesis of subunits V and VII of cytochrome c oxidase were examined in the heme-deficient yeast mutant, GL1. In vitro translation and immunodetection with subunit-specific antisera indicated a 50% decrease in both proteins, with RNA obtained from hemeless cells. Unsupplemented, pulse-label...

journal_title：Biochemical and biophysical research communications

authors： Gollub EG,Dayan J

更新日期：1985-05-16 00:00:00

abstract：:Metallodaunomycin has been shown to cleave DNA only in the presence of oxygen, a reducing agent and a metal ion under reaction conditions similar to those used for the cuprous-phenanthroline complex. The intermediacy of 02-. and H2O2 has been substantiated by experiments with superoxide dismutase and catalase, respect...

journal_title：Biochemical and biophysical research communications

authors： Mariam YH,Glover GP

更新日期：1986-04-14 00:00:00

abstract：:Deficiency in the enzyme adenosine deaminase (ADA) in humans manifests primarily as severe lymphopenia and immunodeficiency, resulting in death by 6 months of age, if untreated. In this review, we discuss phenotypical, biochemical, and metabolic hallmarks of the disease, and describe a mouse model in which levels of A...

journal_title：Biochemical and biophysical research communications

authors： Aldrich MB,Blackburn MR,Kellems RE

更新日期：2000-06-07 00:00:00

abstract：:Insulin and glucagon secretion from the islets of Langerhans is highly regulated. Although an increased plasma glucose level is the major stimulus for insulin exocytosis, roles for glutamine and glutamate have been suggested. Interestingly, the islet cells display elements associated with synaptic transmission. In the...

journal_title：Biochemical and biophysical research communications

authors： Gammelsaeter R,Jenstad M,Bredahl MK,Gundersen V,Chaudhry FA

更新日期：2009-04-10 00:00:00

abstract：:The processing of human gastric procathepsin E to its mature form, cathepsin E, was studied at pH 3.5. The results revealed the autocatalytic and apparently one-step conversion of procathepsin E to cathepsin E within 10 min of incubation at 14 degrees C under the conditions used. Analyses of the amino acid sequences o...

journal_title：Biochemical and biophysical research communications

authors： Athauda SB,Takahashi T,Kageyama T,Takahashi K

更新日期：1991-02-28 00:00:00

abstract：:The characteristics of carcinoembryonic antigen (CEA) molecules expressed by different cell types have been examined using cDNA transfection into cells of epithelial, neuroectodermal and hematopoietic origin. Variability in the CEA molecules was observed in terms of monoclonal antibody binding, apparent molecular weig...

journal_title：Biochemical and biophysical research communications

authors： Grimm T,Riethmüller G,Johnson JP

更新日期：1994-11-15 00:00:00

abstract：:DNase coatings show great potential to prevent biofilm formation in various applications of the medical implant, food and marine industry. However, straightforward and quantitative methods to characterize the enzymatic activity of these coatings are currently not available. We here introduce the qDNase assay, a quanti...

journal_title：Biochemical and biophysical research communications

authors： Van der Gucht M,Aktan MK,Hendrix H,Velde GV,Paeshuyse J,Braem A,Lavigne R

更新日期：2021-01-01 00:00:00

abstract：:The upstream activating region that controls cellulose-induced expression of the glucose-repressible cellobiohydrolase I gene (UARcb1) of the filamentous fungus Trichoderma reesei is shown to mediate transcription and glucose repression of a reporter gene in Saccharomyces cerevisiae, a unicellular microorganism that l...

journal_title：Biochemical and biophysical research communications

authors： Carraro DM,Ferreira Júnior JR,Schumacher R,Pereira GG,Hollenberg CP,El-Dorry H

更新日期：1998-12-18 00:00:00

abstract：:Anandamide (arachidonylethanolamide) has been identified as a brain constituent that selectively binds to the cannabinoid receptor and possesses cannabimimetic activity. Cytochromes P450 catalyze the oxidation of arachidonic acid to several metabolites possessing very potent pharmacological activity. We examined wheth...

journal_title：Biochemical and biophysical research communications

authors： Bornheim LM,Kim KY,Chen B,Correia MA

更新日期：1993-12-15 00:00:00

abstract：:A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library. The cDNA sequence contains an open reading frame of 1434 bp that encodes 478 amino acid residues with a predicted molecular mass of 53.9 kDa. Sequence pattern analysis shows that BPOZ contains a...

journal_title：Biochemical and biophysical research communications

authors： Dai KS,Wei W,Liew CC

更新日期：2000-07-14 00:00:00

abstract：:As we reported before, exoglycosidase treatment of human serum IgA1 changed it to a sticky molecule. In order to examine the presence of the specific binding protein to the sticky IgA1 in human serum, IgA1, asialo-IgA1 (IgA1-S) and asialo-, agalacto-IgA1 (IgA1-SG)/Sepharose column chromatography of normal human serum ...

journal_title：Biochemical and biophysical research communications

authors： Iwase H,Yokozeki Y,Hiki Y,Tanaka A,Kokubo T,Sano T,Ishii-Karakasa I,Hisatani K,Kobayashi Y,Hotta K

更新日期：1999-10-22 00:00:00

abstract：:We have reported that the principal neutralizing domain of V3 of the HIV-1 gp120 induces an antigen-specific activation apoptosis of responding effector CD4+ T lymphocytes, a phenomenon inhibited by RANTES, an agonist of CCR5. Here, addressing the question of how a hypervariable region could induce such a selective re...

journal_title：Biochemical and biophysical research communications

authors： Baritaki S,Zafiropoulos A,Sioumpara M,Politis M,Spandidos DA,Krambovitis E

更新日期：2002-11-08 00:00:00

abstract：:We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to IR, respectively, were treated with the combinations of FTD and IR, and evaluated by the clonog...

journal_title：Biochemical and biophysical research communications

authors： Matsuoka K,Kobunai T,Nukatsuka M,Takechi T

更新日期：2017-12-09 00:00:00

abstract：:Upregulation of insulin-like growth factor (IGF)-II expression has been reported for a variety of childhood and adulthood tumors. We determined IGF-II gene promoter usage in human cancerous and benign tissues by semiquantitative RT-PCR using P1-P4-specific primers. Although the human IGF-II gene structure is commonly ...

journal_title：Biochemical and biophysical research communications

authors： Mineo R,Fichera E,Liang SJ,Fujita-Yamaguchi Y

更新日期：2000-02-24 00:00:00

abstract：:The distribution and intracellular translocation of AFB1 in various subcellular fractions was investigated in isolated hepatocytes by pulse-chase experiments. After labeling the hepatocytes with [3H]-AFB1 (14.5 nM) for 15 min, the highest concentration of [3H]-AFB1 was found in the cytosolic fraction where 66% was bou...

journal_title：Biochemical and biophysical research communications

authors： Ch'ih JJ,Devlin TM

更新日期：1984-07-18 00:00:00

abstract：:The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effec...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Wu K,Zhang L,Gao L,Chen S

更新日期：2018-02-26 00:00:00

abstract：:Immediately from the outset of the COVID-19 pandemic, researchers from diverse biomedical and biological disciplines have united to study the novel pandemic virus, SARS-CoV-2. The antibody response to SARS-CoV-2 has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and the...

journal_title：Biochemical and biophysical research communications

authors： Yuan M,Liu H,Wu NC,Wilson IA

更新日期：2020-10-10 00:00:00

abstract：:Dimerization-induced activation of LXR is a unique allosteric mechanism described only for LXR/RXR heterodimers. Previously, we demonstrated that RXR functions as an allosteric activator of LXR binding to ASC-2 coactivator rather than as a direct interaction partner. Here, we investigated the molecular basis of the in...

journal_title：Biochemical and biophysical research communications

authors： Son YL,Lee YC

更新日期：2009-07-03 00:00:00

abstract：:Midkine (MK) is a novel growth factor and is the product of a retinoic acid responsive gene. When P19 murine embryonal carcinoma (EC) cells were exposed to MK, they differentiated into neurons, and the neuronal differentiation was accompanied by expression of choline acetyltransferase activity. Synthesis and release o...

journal_title：Biochemical and biophysical research communications

authors： Michikawa M,Xu RY,Muramatsu H,Muramatsu T,Kim SU

更新日期：1993-05-14 00:00:00

abstract：:This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells. Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells. IL-1 was found to elicit a dose-dependent rise in adenyl c...

journal_title：Biochemical and biophysical research communications

authors： Weitzmann MN,Savage N

更新日期：1993-01-29 00:00:00

abstract：:Evidence of a complex formation is a crucial step in the structural studies of ligand-receptor interactions. Here we presented a simple and fast approach for qualitative screening of the complex formation between the chimeric extracellular domain of the nicotinic acetylcholine receptor (α7-ECD) and three-finger protei...

journal_title：Biochemical and biophysical research communications

authors： Kulbatskii DS,Shulepko MA,Sluchanko NN,Yablokov EO,Kamyshinsky RA,Chesnokov YM,Kirpichnikov MP,Lyukmanova EN

更新日期：2020-10-29 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine which is highly expressed in skeletal muscle, and which stimulates muscle protein accretion in cultured skeletal muscle fibers. Using parental C2 skeletal myoblasts, no significant effects of IL-15 on skeletal muscle differentiation were observed. To test the hypothesis that IL-15 ...

journal_title：Biochemical and biophysical research communications

authors： Quinn LS,Haugk KL,Damon SE

更新日期：1997-10-09 00:00:00

abstract：:Myotonic dystrophy (DM) is an autosomal dominant human disorder, caused by the abnormal expansion of a CTG trinucleotide repeat in the 3' untranslated region of a protein kinase gene (DMPK). Muscle symptoms are a common feature of the disorder and in the adult onset cases there are increased patterns of muscle fibre d...

journal_title：Biochemical and biophysical research communications

authors： Okoli G,Carey N,Johnson KJ,Watt DJ

更新日期：1998-05-29 00:00:00

abstract：:Activin belongs to transforming growth factor (TGF)-β super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew w...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Wang JH,Xu C,Sun B,Kang SO

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:DMSO is routinely infused together with hematopoietic cells in patients undergoing myeloablative therapy and was recently found to inhibit smooth muscle cells proliferation and arterial thrombus formation in the mouse by preventing tissue factor (TF), a key activator of the coagulation cascade. This study wa...

journal_title：Biochemical and biophysical research communications

authors： Asmis L,Tanner FC,Sudano I,Lüscher TF,Camici GG

更新日期：2010-01-22 00:00:00

abstract：:Glucose depressed DNA synthesis in rat hepatocytes in primary culture. As compared to controls cultured with 5.6 mM glucose, maximal (> or = 75%) inhibition was obtained at 20-30 mM, and half-maximal effect at 10-15 mM. Comparison of D- and L-glucose showed that the effect was specific for the D-form. Maximal inhibiti...

journal_title：Biochemical and biophysical research communications

authors： Dajani OF,Refsnes M,Guren TK,Horn RS,Thoresen GH,Christoffersen T

更新日期：1994-08-15 00:00:00