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The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism.

Abstract：

:Anandamide (arachidonylethanolamide) has been identified as a brain constituent that selectively binds to the cannabinoid receptor and possesses cannabimimetic activity. Cytochromes P450 catalyze the oxidation of arachidonic acid to several metabolites possessing very potent pharmacological activity. We examined whether P450 would also metabolize anandamide, and whether cannabidiol (a cannabinoid which inactivates several P450s) would affect this metabolism. Mouse hepatic P450s were found to metabolize anandamide to at least 10 different metabolites, four of which were characterized by mass spectrometry. Cannabidiol selectively inhibited the formation of two of these four anandamide metabolites. The significance of anandamide metabolism remains to be explored.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bornheim LM,Kim KY,Chen B,Correia MA

doi

10.1006/bbrc.1993.2541

subject

Has Abstract

pub_date

1993-12-15 00:00:00

pages

740-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X83725416

journal_volume

197

pub_type

杂志文章

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