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Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms.

Abstract：

:SIRT5 is one of the seven mammalian sirtuins which are NAD+-dependent deacylases. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. Previous studies have focused mostly on SIRT5iso1. Characteristics regarding localization, activity and tissue distribution of the other three SIRT5 isoforms remain unclear. In the present study, we characterized these properties of these SIRT5 isoforms. We found that SIRT5iso1-3 were mitochondria-localized, while SIRT5iso4 localized mainly in cytoplasm. SIRT5iso2-4 had little deacylase activity comparing with SIRT5iso1. Although cDNAs of all SIRT5 isoforms were readily detected in multiply tissues according to EST database, proteins of SIRT5iso2-4 were seldom observed in human cell lines. Altogether, we dissected the four isoforms of human SIRT5 protein.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Du Y,Hu H,Hua C,Du K,Wei T

doi

10.1016/j.bbrc.2018.06.073

subject

Has Abstract

pub_date

2018-09-05 00:00:00

pages

763-769

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31385-8

journal_volume

503

pub_type

杂志文章

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