Vascular actions of C-type natriuretic peptide in isolated porcine coronary arteries and coronary vascular smooth muscle cells.


:C-type natriuretic (CNP) caused concentration-dependent relaxations in porcine coronary arteries with a maximal relaxation (10(-6)M) of 46%. Relaxations to CNP in isolated coronary arteries were significantly attenuated with potassium channel antagonists charybdotoxin (10(-7)M) and glibenclamide (10(-7)M). Membrane potential and K+ currents were measured in enzymatically dissociated smooth muscle cells from porcine coronary arteries with patch-clamp techniques in a whole-cell mode (n = 5). CNP caused K+ channel activation and membrane hyperpolarization in a dose-dependent manner. This hyperpolarization was markedly suppressed by the potassium channel inhibitor tetraethylammonium (TEA, 5 mM). These results demonstrate that CNP relaxes porcine coronary arterial smooth muscle by hyperpolarization of vascular smooth muscle through potassium channel stimulation.


Wei CM,Hu S,Miller VM,Burnett JC Jr




Has Abstract


1994-11-30 00:00:00














  • Identification of a novel growth hormone binding protein mRNA in rat liver.

    abstract::The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tiong TS,Herington AC

    更新日期:1991-10-31 00:00:00

  • Kinetic study of porcine kidney betaine aldehyde dehydrogenase.

    abstract::Porcine kidney betaine aldehyde dehydrogenase (EC kinetic properties were determined at low substrate concentrations. The double-reciprocal plots of initial velocity versus substrate concentration are linear and intersect at the left of the 1/v axis and showed substrate inhibition with betaine aldehyde. Studi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Figueroa-Soto CG,Valenzuela-Soto EM

    更新日期:2000-03-16 00:00:00

  • Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3.

    abstract::Usefulness of adenoviral vectors derived from human adenovirus (HAd) type 5 (HAd5) is mainly limited by wide prevalence of preexisting anti-HAd5 immunity as well as non-specific tissue tropism of these vectors. As an alternative, non-human adenoviral vectors including bovine adenovirus type 3 (BAd3) are currently bein...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bangari DS,Sharma A,Mittal SK

    更新日期:2005-06-17 00:00:00

  • Hydration of sodium hyaluronate, NMR study of an oriented sample.

    abstract::A sample of highly oriented Na-hyaluronate was prepared with a wet--spinning method and equilibrated to 75% relative humidity. Its proton NMR spectrum was recorded as a function of the angle theta between the hyaluronate helix axis and the external magnetic field. It appeared as a singlet with an angle-dependent line ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lahajnar G,Rupprecht A

    更新日期:1986-11-26 00:00:00

  • Inhibition by vanadyl of adenylate cyclase activation reactions in rat adrenal membranes.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hayashi Y,Kimura T

    更新日期:1985-08-15 00:00:00

  • Substrate specificity of penicillin acylase from Streptomyces lavendulae.

    abstract::The kinetic parameters of several substrates of penicillin acylase from Streptomyces lavendulae have been determined. The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydroF, and K. The best substrate was penicillin K (octanoyl penic...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Torres-Guzmán R,de la Mata I,Torres-Bacete J,Arroyo M,Castillón MP,Acebal C

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  • Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Koyama S,Wada-Hiraike O,Nakagawa S,Tanikawa M,Hiraike H,Miyamoto Y,Sone K,Oda K,Fukuhara H,Nakagawa K,Kato S,Yano T,Taketani Y

    更新日期:2010-02-12 00:00:00

  • Potent inhibition of CTLA-4 expression by an anti-CTLA-4 ribozyme.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cepero E,Hnatyszyn HJ,Kraus G,Lichtenheld MG

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  • Anti-apoptotic peptides protect against radiation-induced cell death.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

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  • Identification of a novel autoantigen UACA in patients with panuveitis.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yamada K,Senju S,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

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  • Cell death pathology: perspective for human diseases.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Agostini M,Tucci P,Melino G

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  • Prolactin stimulation of protein kinase C activity in the rat hypothalamus.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: DeVito WJ,Stone S,Avakian C

    更新日期:1991-04-30 00:00:00

  • Exosome from chaperone-rich cell lysates-loaded dendritic cells produced by CELLine 1000 culture system exhibits potent immune activity.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Luu NX,Driscoll WJ,Martin BM,Strott CA

    更新日期:1995-12-26 00:00:00

  • Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang N,Zhang Y,Zhao S,Sun Y

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Grimaldi M,Florio T,Schettini G

    更新日期:1997-06-09 00:00:00

  • Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Khomenko T,Deng X,Jadus MR,Szabo S

    更新日期:2003-10-03 00:00:00

  • Genomic cloning and characterization of the mouse POZ/zinc-finger protein ZF5.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yokoro K,Yanagidani A,Obata T,Yamamoto S,Numoto M

    更新日期:1998-05-29 00:00:00

  • Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TTV infection.

    abstract::Fecal supernatant or serum containing TT virus (TTV) of genotype 1a (10(5) copies/ml) from patients with acute TTV infection was inoculated intravenously into two naive chimpanzees. Serum samples were obtained weekly and tested for TTV DNA by genotype 1-specific polymerase chain reaction. TTV DNA was detected in chimp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tawara A,Akahane Y,Takahashi M,Nishizawa T,Ishikawa T,Okamoto H

    更新日期:2000-11-19 00:00:00

  • Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hsu HC,Yang WC,Tsai WJ,Chen CC,Huang HY,Tsai YC

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  • Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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  • Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 临床试验,杂志文章


    authors: Suzuki A,Yamada R,Ohtake-Yamanaka M,Okazaki Y,Sawada T,Yamamoto K

    更新日期:2005-07-29 00:00:00

  • Rv2477c is an antibiotic-sensitive manganese-dependent ABC-F ATPase in Mycobacterium tuberculosis.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Daniel J,Abraham L,Martin A,Pablo X,Reyes S

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jeon SB,Ji KA,You HJ,Kim JH,Jou I,Joe EH

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang CC,Kadota M,Nishigaki R,Kazuki Y,Shirayoshi Y,Rogers MS,Gojobori T,Ikeo K,Oshimura M

    更新日期:2004-02-06 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cosić I,Nesić D,Pavlović M,Williams R

    更新日期:1986-12-15 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Takizawa M,Harada K,Nakamura K,Tsuboi T

    更新日期:2018-07-02 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Park SC,Lee JR,Shin SO,Park Y,Lee SY,Hahm KS

    更新日期:2007-10-26 00:00:00