Inhibition of cytochrome P-450-linked monooxygenase systems by naphthoquinones.

abstract：:Ophiopogonin D (OPD) is the chief pharmacological active component of the traditional Chinese herbal prescription drug-Shenmai injection (SMI), which has been used to prevent and treat cardiovascular diseases. In the present study, we investigated whether OPD protectively relieve cardiac hypertrophy against inflammati...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang X,Ma Z,Wang Y,Chen X,Gao Y

更新日期：2018-09-05 00:00:00

abstract：:The molecular mechanisms underlying ultrasound-induced apoptosis remain poorly understood. We have demonstrated that in Jurkat cells, the over-expression of the anti-apoptotic protein Bcl-2 inhibited ultrasound-induced apoptosis, but not necrosis. Inhibition of caspase activity also protected the cells from apoptosis,...

journal_title：Biochemical and biophysical research communications

authors： Kinoshita M,Eguchi Y,Hynynen K

更新日期：2007-02-09 00:00:00

abstract：:Bcl10 is a signaling protein required for activation of the NF-kappaB transcription factor. NF-kappaB is an important mediator of genotoxic stress and regulates the expression of genes required for both cell proliferation and cell death. Bcl10 is phosphorylated in vivo, however, the protein kinase or kinases responsib...

journal_title：Biochemical and biophysical research communications

authors： Bodero AJ,Ye R,Lees-Miller SP

更新日期：2003-02-21 00:00:00

abstract：:Alzheimer's disease is a growing concern in the context of the increasing lifespan of the populations. The work presented here is part of the fight against this threat. It supports a therapeutic approach to reduce the incidence of Alzheimer's disease, taking advantage of the specific binding of several domains of Netr...

journal_title：Biochemical and biophysical research communications

authors： Borel F,Marzocca F,Delcros JG,Rama N,Mehlen P,Ferrer JL

更新日期：2017-07-01 00:00:00

abstract：:The initiating factors in primary, idiopathic osteoarthritis are unknown, the characteristic bone and cartilage changes being late features of the disease. We have proposed that biochemical cruciate ligament alteration may be important in early osteoarthritis by mediating loading consequences on the bone and cartilage...

journal_title：Biochemical and biophysical research communications

authors： Anderson-MacKenzie JM,Billingham ME,Bailey AJ

更新日期：1999-05-19 00:00:00

abstract：:The antiherpetic agent 9-beta-D-arabinofuranosyladenine (araA) needs to be phosphorylated to its 5'-triphosphate to be effective as an inhibitor of herpes simplex virus replication. Adenosine kinase and deoxycytidine kinase are assumed to convert araA to its 5'-monophosphate. We now found that araAMP is converted to i...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,De Clercq E

更新日期：1990-12-31 00:00:00

abstract：:Autophagy is a physiologically regulated and evolutionary conserved process that plays a critical role in degradation of cytoplasmic proteins and other macromolecules within the lysosomes. Beclin-1, the mammalian orthologue of yeast Atg6, is an important mediator of autophagy that has been studied in many human cancer...

journal_title：Biochemical and biophysical research communications

authors： Kapoor V,Paliwal D,Baskar Singh S,Mohanti BK,Das SN

更新日期：2012-06-15 00:00:00

abstract：:Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrulline residues Ca(2+)-dependently. PAD V was recently found in granulocyte-differentiated HL-60 cells. To find a target of PAD V, we incubated HL-60 granulocytes with the calcium ionophore A23187 and studied deiminated proteins by immun...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara T,Nakashima K,Hirano H,Senshu T,Yamada M

更新日期：2002-01-25 00:00:00

abstract：:Phosphorylation of regulatory light chain (LC20) by myosin light chain kinase (MLCK) has been thought to play an important role in both smooth muscle contraction and several functions of vertebrate non-muscle cells. Amiloride, a frequently used Na+/H+ exchange inhibitor, potently inhibited phosphorylation of LC20 by M...

journal_title：Biochemical and biophysical research communications

authors： Higashihara M

更新日期：1989-08-15 00:00:00

abstract：:Successful seed germination depends on the rapid repair of cell membrane damaged by dry storage. However, little is known about the reorganization of lipids during this process. In this study, the changes of intracellular redox environment, cell membrane integrity, lipid composition, and expression of genes related to...

journal_title：Biochemical and biophysical research communications

authors： Lin YX,Xin X,Yin GK,He JJ,Zhou YC,Chen JY,Lu XX

更新日期：2019-07-23 00:00:00

abstract：:HspA1A, a seventy-kilodalton heat shock protein, binds to specific anionic lipids and this interaction regulates important physiological phenomena like apoptosis, tumor growth, and lysosomal rescue. However, whether HspA1A binds to phosphoinositides has yet to be established and quantified. Therefore, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： McCallister C,Kdeiss B,Oliverio R,Nikolaidis N

更新日期：2016-03-25 00:00:00

abstract：:A specific peptide (SAMS peptide) phosphorylation assay has previously been used to measure and subsequently purify rat liver 5'-AMP-activated protein kinase (AMPK). In this report, we show that this peptide and a peptide based on the sequence surrounding the site phosphorylated on 3-hydroxy-3-methylglutaryl-CoA (HMG-...

journal_title：Biochemical and biophysical research communications

authors： Sullivan JE,Carey F,Carling D,Beri RK

更新日期：1994-05-16 00:00:00

abstract：:We used fluorescence correlation spectroscopy (FCS) to study the activation of fibrinogen by thrombin and the subsequent aggregation of fibrin monomers into fibrin polymers at a very low and at physiological fibrinogen concentrations. In the labeling procedure used the fibrinogen was randomly labeled and the label was...

journal_title：Biochemical and biophysical research communications

authors： Bark N,Földes-Papp Z,Rigler R

更新日期：1999-06-24 00:00:00

abstract：:We provide the first functional evidence that calcitonin gene-related peptide (8-37) induces a direct vasoconstriction and reversibly antagonizes vasodilation of the mesenteric arterial bed induced by calcitonin gene-related peptide (CGRP) suggesting that CGRP (8-37) is a competitive antagonist of vascular CGRP recept...

journal_title：Biochemical and biophysical research communications

authors： Han SP,Naes L,Westfall TC

更新日期：1990-04-30 00:00:00

abstract：:Disturbance of endoplasmic reticulum (ER) homeostasis causes ER stress (ERS), and triggers the unfolded protein response (UPR) that consequently reduces accumulation of unfolded proteins by increasing the quantity of ER chaperones. Calumenin, a Ca(2+)-binding protein with multiple EF hand motifs, which is located in t...

journal_title：Biochemical and biophysical research communications

authors： Lee JH,Kwon EJ,Kim DH

更新日期：2013-09-27 00:00:00

abstract：:A significant percentage of the methyltransferasome in Saccharomyces cerevisiae and higher eukaryotes is devoted to methylation of the translational machinery. Methylation of the RNA components of the translational machinery has been studied extensively and is important for structure stability, ribosome biogenesis, an...

journal_title：Biochemical and biophysical research communications

authors： Al-Hadid Q,White J,Clarke S

更新日期：2016-02-12 00:00:00

abstract：:As part of an effort to identify genes potentially involved in the Down Syndrome pathogenesis, in this paper we report the identification and characterization of a new human gene (named SH3BGRL), which shows a high homology to the SH3BGR gene, previously mapped to the Down Syndrome region of chromosome 21. The SH3BGRL...

journal_title：Biochemical and biophysical research communications

authors： Egeo A,Mazzocco M,Arrigo P,Vidal-Taboada JM,Oliva R,Pirola B,Giglio S,Rasore-Quartino A,Scartezzini P

更新日期：1998-06-18 00:00:00

abstract：:The aim of the present study was to accomplish de novo generation of reconstituted human skin with enriched hair follicles. Dermal papillae (DP) are known to play a crucial organizing role in hair follicle induction. However, generation of enriched human hair follicles using cultured DP cells has not been accomplished...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Soma T,Matsuzaki T,Kishimoto J

更新日期：2019-08-27 00:00:00

abstract：:Circular (circ)RNAs have been implicated in cancer development. However, few studies have examined the role of circRNAs in papillary thyroid cancer (PTC). In this study we found that circNUP214 was upregulated in clinical PTC specimens relative to adjacent normal tissue. In vitro analyses showed that circNUP214 knockd...

journal_title：Biochemical and biophysical research communications

authors： Li X,Tian Y,Hu Y,Yang Z,Zhang L,Luo J

更新日期：2018-12-09 00:00:00

abstract：:HL-60 nuclear autophosphorylation was studied in vitro under circumstances in which the conformation of chromatin was manipulated with both polyamines and DNAse-I. A general re-arrangement of the phosphorylation patterns occurred as polyamines were removed and nuclei were observed to expand. DNAse-I treatment reduced ...

journal_title：Biochemical and biophysical research communications

authors： Testori A,Skinner JD,Murray AW,Burgoyne LA

更新日期：1991-10-15 00:00:00

abstract：:A novel nuclear magnetic resonance (NMR) spectroscopy probe was designed and constructed for the study of transient metabolic changes in cellular systems during exposure to ionizing radiation. The probe incorporated a bioreactor, a radiation source, and a radiofrequency detection circuit tunable between 100 and 300 MH...

journal_title：Biochemical and biophysical research communications

authors： Magness JE,McFarland EW

更新日期：1997-04-07 00:00:00

abstract：:Global rise in obesity at early age due to overconsumption of energy-dense food is the major health problem which increases the exposure to obesity over longer duration. Recently we reported that the severity of ovarian dysfunction depends on the duration of obesity. In the present study, we examined the consequences ...

journal_title：Biochemical and biophysical research communications

authors： Kannan S,Bhaskaran RS

更新日期：2019-11-12 00:00:00

abstract：:Xylan from Rhodymenia palmata binds to the cellobiohydrolase I from Trichoderma reesei (CBH I) or its core protein, inhibiting their activity. Adsorption onto microcrystalline cellulose (Avicel) is reduced approximately 30% for intact CBH I and nearly 50% for the core, whereas the effects with cellobiose are negligibl...

journal_title：Biochemical and biophysical research communications

authors： Abuja PM,Pilz I,Tomme P,Claeyssens M

更新日期：1989-12-15 00:00:00

abstract：:The distribution of somatostatin immunoreactive forms in three tissues of the anglerfish (Lophius piscatorius L.) was analyzed by a combination of gel permeation, High Pressure Liquid Chromatography and amino acid analysis. The data indicate that prosomatostatins I and II are expressed in both neural and gastro-intest...

journal_title：Biochemical and biophysical research communications

authors： Morel A,Kuks PF,Bourdais J,Cohen P

更新日期：1988-02-29 00:00:00

abstract：:A novel N-terminally substituted Pro(3) analogue of glucose-dependent insulinotropic polypeptide (GIP) was synthesized and tested for plasma stability and biological activity both in vitro and in vivo. Native GIP was rapidly degraded by human plasma with only 39 +/- 6% remaining intact after 8 h, whereas (Pro(3))GIP w...

journal_title：Biochemical and biophysical research communications

authors： Gault VA,O'Harte FP,Harriott P,Flatt PR

更新日期：2002-02-08 00:00:00

abstract：:Available evidence suggests that insulin-like growth factor I receptor (IGF-IR) expression leads to increased cellular radioresistance. The most direct explanation of these findings predicts that IGF-IR is the source of survival signals in resistant cells. Mutational analysis revealed that protein truncated at amino a...

journal_title：Biochemical and biophysical research communications

authors： Yu D,Shibuya H,Miura M

更新日期：2003-11-07 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:2,3 Dehydro-2-deoxy-N-acetyl-neuraminic acid (DNANA) competitively inhibits the neuraminidase activity of Hemagglutinin-neuraminidase (HN) from Sendai virus. The inhibition constant depends on the presence of the Fusion (F) protein, which is 30 microM in the presence of active F protein and 50 microM when the F protei...

journal_title：Biochemical and biophysical research communications

authors： Dallocchio F,Tomasi M,Bellini T

更新日期：1995-03-08 00:00:00

abstract：:Dexamethasone (DEX), a potent glucocorticoid, increased the expression of T-cell death associated gene 8 (TDAG8), a proton-sensing G protein-coupled receptor, which is associated with the enhancement of acidic pH-induced cAMP accumulation, in peritoneal macrophages. We explored the role of increased TDAG8 expression i...

journal_title：Biochemical and biophysical research communications

authors： He XD,Tobo M,Mogi C,Nakakura T,Komachi M,Murata N,Takano M,Tomura H,Sato K,Okajima F

更新日期：2011-12-02 00:00:00

abstract：:Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporal-spatial manner. The C(2)H(2) zinc finger-containing transcription factors have been implicated as critical regulators of multiple cardiac-expressed genes and ar...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Wang Y,Zhang C,Yuan W,Wang J,Zhu C,Chen L,Huang W,Zeng W,Wu X,Liu M

更新日期：2004-12-24 00:00:00